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InfoMedSearch 2012 Archives
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The sections below contain selected medical-health article links for our Featured InfoMedLinks, Inflammation and Oxidative Stress, and Patient Safety:
Active Lifestyles Slow Progression Of Alzheimer's “The doctor said that an important part of the study was its emphasis on having a large variety of different lifestyle choices. He said, "What struck me most about the study results is that it is not one but a combination of lifestyle choices and activities that benefit the brain." He noted that the impact of an active lifestyle on the brain was probably due to improved vascular health. "Virtually all of the physical activities examined in this study are some kind of variation of aerobic physical activity, which we know from other work can improve cerebral blood flow and strengthen neuronal connections.”
Cardiovascular Risk Factors Promote Brain Hypoperfusion Leading to Cognitive Decline and Dementia (Cardiovasc Psychiatry Neurol. 2012)
Frailty syndrome and the risk of vascular dementia. The Italian Longitudinal Study on Aging. (Alzheimers Dement. 2012)
Higher Blood Pressure May Harm the Middle-Aged Brain, Study Finds “Structural damage was found even in the brains of young middle-aged people who had pre-hypertension, in which blood pressure is elevated but not to the level considered to be high blood pressure.”
Is psycho-physical stress a risk factor for stroke? A case-control study. (J Neurol Neurosurg Psychiatry. 2012)
Overview of resistant hypertension: A glimpse of the cardiologist's current standpoint. (World J Cardiol. 2012 )
Physical Activity Reduces Salt Sensitivity of Blood Pressure (Am. J. Epidemiol. (2012)) “Physical activity is significantly, independently, and inversely related to salt sensitivity of BP and may be particularly effective in lowering BP among salt-sensitive individuals.”
Statin use in postmenopausal women is associated with an increased risk of incident diabetes mellitus (Evid Based Med 2012;17 192-193)
Activity Participation and Cognitive Aging from Age 50 to 80 in the Glostrup 1914 Cohort (Journal of the American Geriatrics Society 2012)
Beyond salt: lifestyle modifications and blood pressure. (Eur Heart J. 2011)
Exercise Makes Middle-Aged People Smarter “High-intensity interval training makes middle-aged people not only healthier but smarter, showed a Montreal Heart Institute (MHI) study led by Dr. Anil Nigam of the MHI and University of Montreal, in collaboration with the Montreal Geriatric University Institute.”
Mediterranean meal may have positive effects on arteries “A single junk food meal - composed mainly of saturated fat - is detrimental to the health of the arteries, while no damage occurs after consuming a Mediterranean meal rich in good fats such as mono-and polyunsaturated fatty acids, according to researchers at the University of Montreal-affiliated éPIC Center of the Montreal Heart Institute. The Mediterranean meal may even have a positive effect on the arteries.”
Mental and Physical Activities Delay Cognitive Decline in Older Persons With Dementia. (Am J Geriatr Psychiatry. 2012)
Nutrients in Fruits, Vegetables May Help Prevent Breast Cancer: Study “They found a statistically significant association between higher levels of carotenoids and reduced breast cancer risk, especially so-called ER-negative breast cancers -- tumors that aren't reliant on estrogen to fuel their growth. The findings highlight carotenoid levels as one of the first modifiable risk factors to be identified for ER-negative breast cancers, the team said.”
Relationship Between Physical Activity and Brain Atrophy Progression (Med Sci Sports Exerc. 2012) “The results indicate that physical activity and total energy expenditure are significant predictors of frontal lobe atrophy progression during an 8-yr period. Promoting participation in activities may be beneficial for attenuating age-related frontal lobe atrophy and for preventing dementia.”
Want A Healthy Brain? Scientists Say, Go For A Run “Physical exercise is just as important as cognitive exercise when it comes to maintaining a healthy brain, according to a new University of Queensland study released this week.”
Inflammation and Oxidative Stress
Exercise protects against high-fat diet-induced hypothalamic inflammation. (Physiol Behav. 2012)
Low Vitamin B6 Linked to Inflammation “Researchers found that people with the lowest levels of vitamin B6 in their blood had the highest levels of chronic inflammation, based on a wide variety of indicators. Those with the most vitamin B6 circulating in the bloodstream were also the least likely to have indicators of inflammation. Temporary inflammation, such as redness and swelling after an injury, is generally a sign that the immune system is actively fighting infection. But chronic inflammation is an emerging risk factor for a wide range of health problems, including heart disease, stroke, and type 2 diabetes. … Blake says vitamin B6 is vital to more than 100 enzyme processes in the body, mostly those involving the metabolism of protein. But there can be too much of a good thing. Studies have shown taking large amounts of vitamin B6 (more than 500 mg a day) can cause nerve damage, difficulty walking, or tingling. "Some is good. More is not better," says Salge Blake. "Just having a well-balanced diet will meet your needs."”
Cholinesterase inhibitors for mild cognitive impairment. (Cochrane Database Syst Rev. 2012) “There is very little evidence that cholinesterase inhibitors affect progression to dementia or cognitive test scores in mild cognitive impairment. This weak evidence is overwhelmed by the increased risk of adverse events, particularly gastrointestinal. Cholinesterase inhibitors should not be recommended for mild cognitive impairment.”
Diagnostic 'Fatal Flaws' in the ICU May Account for as Many Annual Deaths as Breast Cancer, Patient Safety Team Finds “Overall, the medical conditions most commonly missed by diagnosticians included heart attack; pulmonary embolism, an artery blockage in the lungs; pneumonia; and aspergillosis, a fungal infection that most commonly affects individuals with a weakened immune system. Cumulatively, these four conditions accounted for about one-third of all illnesses that doctors failed to detect.”
Expensive Health Care Isn’t Always Best “Santa points out that the U.S. health care system outspends the rest of the world, but has worse outcomes than many other industrialized nations. He says the overuse of expensive medical tests and invasive treatments is a big part of the problem.”
Routine Checkups Don't Cut Cancer, Heart Deaths: Study “The goal of such checkups is to catch early signs of disease and thereby reduce the risk for early death. But the fresh review of 14 previous studies involving nearly 183,000 patients uncovered no evidence that such checkups do anything of the sort. On the contrary, the research team found that routine checkups of healthy people may actually promote the use of potentially harmful invasive testing while at the same time leading to overdiagnosis and unnecessary treatment.”
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