Aging - Anti-Aging
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Aging - Anti-Aging
General Information
NEWS:
Calcium Plus Vitamin-D Supplementation Does An Older Body Good
Falls Spell Health Danger for Elderly "In older people, even a simple fall can cause a serious fracture of the arm, hand, ankle or hip. For example, only about half of older adults who are hospitalized for a broken hip return home or are able to live on their own after the injury."
Low Testosterone Could Increase Death Risk "A U.S. team found that older males with relatively low testosterone had an 88 percent increased risk of death compared with their counterparts with normal testosterone levels, researchers report."
Older Adults May Need B12 Dose More Than 200 Times the RDA to Normalize Mild Vitamin Deficiency
So Big and Healthy Grandpa Wouldn’t Even Know You
The Brain: Waste Not, Want Not
Your Dad Had More Testosterone Than You "Scientists have known for years that testosterone rates in men begin declining naturally in the third decade of life, but this is the first study to document an overall generational decrease. … Severe loss of testosterone can cause male hypogonadism, a condition in which male sex glands fail to secrete adequate levels of hormones, resulting in loss of skeletal muscle and bone mass and impairment of sexual activity. But even smaller deficiencies have been associated with increased rates of diabetes and cardiovascular disease."
ARTICLES:
Healthy Aging: The 30s -- And Baby Makes Three
How The Five Senses Change With Age
What is successful ageing and who should define it?
JOURNAL ARTICLES:
A genotype of exceptional longevity is associated with preservation of cognitive function (NEUROLOGY 2006)
Age-related neuropathology, cognitive decline, and Alzheimer's disease (Ageing Research Reviews 2006)
Aging of the brain, entropy, and Alzheimer disease
Association Between Blood Pressure and Survival over 9 Years in a General Population Aged 85 and Older. (J Am Geriatr Soc. 2006) "RESULTS: After adjusting for age, sex, functional status, and coexisting diseases (earlier-diagnosed myocardial infarction, congestive heart failure, dementia, cancer, stroke, or hypertension), low systolic blood pressure (BP) was associated with risk of death. CONCLUSION: Low systolic BP may be partially related to poor general health and poor vitality, but the very old may represent a select group of individuals, and the use of BP-lowering medications needs to be evaluated in this group."
Brain aging in very old men with type 2 diabetes: the honolulu-Asia aging study. (Diabetes Care. 2006) "CONCLUSIONS: There is evidence that older individuals with type 2 diabetes have an elevated risk for vascular brain damage and neurodegenerative changes. These pathological changes may be the anatomical basis for an increased risk of cognitive impairment or dementia in type 2 diabetes."
Case Reports in Urology: Androgen Deficiency in the Aging Male (Clinical Geriatrics 2006)
Characteristics of 32 supercentenarians. (J Am Geriatr Soc. 2006)
Cognitive Function in Normal-Weight, Overweight, and Obese Older Adults: An Analysis of the Advanced Cognitive Training for Independent and Vital Elderly Cohort (Journal of the American Geriatrics Society 2006)
Definitions and predictors of successful aging: a comprehensive review of larger quantitative studies. (Am J Geriatr Psychiatry.)
Depression, Apolipoprotein E Genotype, and the Incidence of Mild Cognitive Impairment (Arch Neurol. 2006) "Conclusions Cognitively normal elderly individuals who develop depression are at increased risk of subsequent MCI. We found a synergistic interaction between depression and apolipoprotein E genotype."
Effect of Aging on Anorectal and Pelvic Floor Functions in Females. (Dis Colon Rectum. 2006)
Effects of aging and atherosclerosis on endothelial and vascular smooth muscle function in humans (International Journal of Cardiology 2006)
Effects of aging and hypertension on the microcirculation. (Hypertension. 2006)
Endocrinology of the aging male. (Minerva Ginecol. 2006)
Evolution of Cognitive Deficits and Conversion to Dementia in Patients with Mild Cognitive Impairment: A Very-Long-Term Follow-Up Study (Dementia and Geriatric Cognitive Disorders 2006)
Falls prevention in practice: guidance and case study. (Br J Community Nurs. 2006)
Frailty in the elderly: the physical dimension. (Eura Medicophys. 2006) "Structured exercise programs are effective in contrasting the progression of frailty, but an healthy and active lifestyle may be sufficient for delaying the onset of disability. In conclusion, there is clear evidence for prescription of exercise within the mainstream of the medical practice, rather than as an optional adjunct to standard care of the oldest old, given the public health implication of frailty, whose prevalence is going to increase in western populations."
Handgrip strength and cognitive decline in older mexican americans. (J Gerontol A Biol Sci Med Sci. 2006) "Conclusion. Older Mexican Americans with reduced handgrip strength at baseline demonstrated a statistically significant decline in cognitive function over a 7-year period. By contrast, participants in the highest handgrip strength quartile maintained a higher level of cognitive function."
Introduction: The adversities of aging. (Ageing Res Rev. 2006)
Longitudinal changes in aerobic capacity: implications for concepts of aging. (J Gerontol A Biol Sci Med Sci. 2006)
l-Carnitine and alpha-lipoic acid improves mitochondrial function during ageing process. (Clin Nutr. 2006) "BACKGROUND & AIMS: The mitochondrion, a major source of oxidants, is also a target for their damaging effects and therefore, mitochondrial oxidative stress appears to be a cause, rather than a consequence, of ageing process. … CONCLUSIONS: The results of the study demonstrate that the protective effect of carnitine plus LA is associated with its antioxidant activity that combines free radical scavenging and metal-chelating properties."
Metabolic Syndrome and Cognitive Function: A Population-Based Follow-Up Study in Elderly Women. (Dement Geriatr Cogn Disord. 2006) "Conclusion: In elderly women, metabolic syndrome may be an important contributor to worsening of memory, which is an essential part of mild cognitive impairment."
Mild cognitive impairment. (Lancet. 2006) "Mild cognitive impairment is a syndrome defined as cognitive decline greater than expected for an individual's age and education level but that does not interfere notably with activities of daily life. Prevalence in population-based epidemiological studies ranges from 3% to 19% in adults older than 65 years. Some people with mild cognitive impairment seem to remain stable or return to normal over time, but more than half progress to dementia within 5 years."
Nutritional factors and immunological ageing. (roc Nutr Soc. 2006)
Occurrence of cognitive impairment after age 90: MCI and other broadly used concepts. (Brain Res Bull. 2006)
Parental longevity and mortality amongst Japanese men and women: the JACC Study (Journal of Internal Medicine 2006) "Our findings indicate that parental longevity could be a predictor for reduced risk of mortality from stroke, cardiovascular disease, and all causes for both Japanese men and women."
Plasma Selenium Over Time and Cognitive Decline in the Elderly. (Epidemiology. 2006) "CONCLUSION:: Selenium status decreases with age and may contribute to declines in neuropsychologic functions among aging people."
Predicting memory decline in normal elderly: Genetics, MRI, and cognitive reserve. (Neurobiol Aging. 2006) "We conclude that APOE-varepsilon4 predicts longitudinal memory decline in healthy controls and that MRI morphometry of hippocampus adds slightly to predictive value."
Predictors of Vitamin B6 and Folate Concentrations in Older Persons: The InCHIANTI Study. (Clin Chem. 2006) "BACKGROUND: Low dietary intake and low serum concentrations of vitamin B6 and/or folate are associated with increased risk of vascular events, possibly because of their association with inflammation, which plays a crucial role in the pathogenesis of cardiovascular diseases. … CONCLUSIONS: Low serum vitamin B6, but not serum folate, concentrations are independent correlates of the proinflammatory state, and both are influenced by antioxidant reserves."
Progression of mild cognitive impairment to dementia: a challenge to current thinking (The British Journal of Psychiatry (2006)) "Results Approximately 60–65% of people with mild cognitive impairment develop clinical dementia during their life. Progression from mild cognitive impairment to dementia appears to be time dependent, occurring primarily within the initial 18 months."
Risk and predictors of motor-performance decline in a normally functioning population-based sample of elderly subjects: the Italian Longitudinal Study on Aging. (J Am Geriatr Soc. 2006)
Successful Mental Health Aging: Results From a Longitudinal Study of Older Australian Men. (Am J Geriatr Psychiatry. 2006)
Testosterone, dehydroepiandrosterone, and physical performance in older men: results from the Massachusetts Male Aging Study. (J Clin Endocrinol Metab. 2006)
The anorexia of aging in humans (Physiology & Behavior 2006)
The Brain Reserve Hypothesis, Brain Atrophy and Aging. (Gerontology. 2006) "Conclusion: Little support was found for the brain reserve hypothesis."
The relative contributions of aging, health, and lifestyle factors to serum testosterone decline in men. (J Clin Endocrinol Metab. 2006) "These results suggest the possibility that age-related hormone decline may be decelerated through the management of health and lifestyle factors."
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