Osteoarthritis
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Osteoarthritis
General Information
NEWS:
Knee Cartilage Defects on MRI May Be Associated With Structural Alterations
ARTICLES:
JOURNAL ARTICLES:
Biologics in development for rheumatoid arthritis: Relevance to osteoarthritis. (Adv Drug Deliv Rev. 2006)
Knee cartilage loss in symptomatic knee osteoarthritis over 4.5 years (Arthritis Research & Therapy 2006) "Tibial cartilage declines at an average rate of 4% per year in subjects with symptomatic knee OA. There was evidence to support the concept that tracking occurs in OA. This may enable the prediction of cartilage change in an individual. The only significant factor affecting the loss of medial tibial cartilage was baseline knee pain, possibly through altered joint loading."
Low levels of vitamin D and worsening of knee osteoarthritis: Results of two longitudinal studies. (Arthritis Rheum. 2006)
Low vitamin K status is associated with osteoarthritis in the hand and knee. (Arthritis Rheum. 2006)"CONCLUSION: These observational data support the hypothesis of an association between low plasma levels of vitamin K and increased prevalence of OA manifestations in the hand and knee."
Osteoporosis and bone metabolism in postmenopausal women with osteoarthritis of the hand. (Menopause. 2006) "OBJECTIVE:: Osteoarthritis and osteoporosis are two major health problems affecting postmenopausal women. Epidemiological observations seem to demonstrate a possible inverse relationship between osteoarthritis and osteoporosis. Erosive osteoarthritis (EOA) of the hand is a destructive form of primary osteoarthritis. This study evaluated bone mineral density and bone metabolism changes in erosive and nonerosive hand osteoarthritis women. … CONCLUSION:: Our data suggest that postmenopausal women with clinical and radiological EOA are at risk for development of osteoporosis."
The association of meniscal pathologic changes with cartilage loss in symptomatic knee osteoarthritis. (Arthritis Rheum. 2006) "CONCLUSION: This study highlights the importance of an intact and functioning meniscus in patients with symptomatic knee OA, since the findings demonstrate that loss of this function has important consequences for cartilage loss."
The relation between joint erosion and generalized osteoporosis and disease activity in patients with rheumatoid arthritis. (Rheumatol Int. 2006) "Radiogram continues to have an important role in determining and following-up the joint erosion seen in patients with RA. However, we believe that as establishing periarticular osteoporosis in the early term by performing BMD measurements on the forearm is correlated with disease activity, it may be useful in the early diagnosis of RA and its objective results will be efficient in predicting the progression of disease."
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