Cervical Cancer

Treatment is updated daily with the most recent articles listed on top.
To view only the last month's articles for the other sub-topics, go to our Monthly Online Newsletters page

If you have any questions regarding our Search Reports, please contact us at info@infomedsearch.com.

Cervical Cancer

Diagnosis, Imaging, and Screening

NEWS:

ACOG Recommends Less Invasive Management of Cervical Cytology Abnormalities in Adolescents

Best Cancer Test: HPV vs. Pap Smear: Study Shows HPV Test Is Better Predictor of Cervical Cancer in Older Women

HPV Test Finds More Precancerous Lesions Than Pap Smears

New Pap Test No Better Than Conventional One

Pap smear still best

ARTICLES:

Cervical Cancer Screening in the HPV Era: What Is the Standard of Care?

NGC - SCREENING FOR CERVICAL CANCER (GUIDELINE SYNTHESIS)

Pap Test

Pap Test (Papanicolaou Smear)

Thinking About Testing for HPV? Information for Women Considering Testing for the Human Papilloma Virus (HPV)

JOURNAL ARTICLES:

Cervical cancer screening, abnormal cytology management, and counseling practices in the United States. (Obstet Gynecol. 2006) "Of the 2,980 (89%) clinicians providing cytologic screening, 99% knew that HPV infection increases cervical cancer risk, and 91% were aware of HPV tests. Of the 21% who reported ever using HPV tests as an adjunct to cytology, more reported usually testing patients aged less than 30 years (which guidelines do not recommend) than older patients (which guidelines do recommend). Of the 63% of clinicians who ever ordered HPV tests for abnormal cytology results, 84% usually ordered tests for ASC-US results and preferentially advised colposcopy if HPV tests were positive, as guidelines recommend. However, more than 60% usually ordered HPV tests for higher-grade abnormalities, which is not recommended for colposcopy triage. Although few sought HPV test consent, most discussed sexually transmitted HPV with patients with abnormal cytology or positive HPV tests despite potentially negative psychosocial consequences. CONCLUSION: New HPV tests and testing guidelines have transformed screening, abnormal cytology management, and counseling practices. Although many U.S. clinicians reported using HPV tests according to guidelines, many also reported inappropriate use."

[Clinical application of sentinel lymph node detection to early stage cervical cancer.] (Ai Zheng. 2006) "CONCLUSIONS: SPECT/CT imaging not only is superior to planar imaging in detecting SLN but also enables precise localization of SLNs. The combined isotope-dye method can improve the accuracy of SLN detection. SLN detection can accurately predict the pelvic lymph nodes status in early stage cervical cancer."

Clinical impact of FDG-PET imaging in post-therapy surveillance of uterine cervical cancer: From diagnosis to prognosis. (Gynecol Oncol. 2006)

Clinical impact of integrated PET/CT on the management of suspected cervical cancer recurrence. (Gynecol Oncol. 2006) "CONCLUSIONS.: In patients with a suspected recurrence of cervical cancer, integrated PET/CT using (18)F-FDG provides good anatomic and functional localization of suspicious lesions, and the better diagnostic interpretation has an impact not only on clinical management and treatment planning of patients, but also on disease-free survival."

Comparative benefits and limitations of (18)F-FDG PET and CT-MRI in documented or suspected recurrent cervical cancer. (Eur J Nucl Med Mol Imaging. 2006) "CONCLUSION: For recurrent cervical cancer, the benefits of FDG PET exceed those of CT-MRI owing to the ability of FDG PET to identify extra-pelvic metastases and its higher sensitivity and specificity."

Comparison of conventional Papanicolaou smear and SurePath liquid-based cytology in the Copenhagen population screening programme for cervical cancer. (Cytopathology. 2006) "This study showed the number of unsatisfactory samples to be significantly reduced with the liquid-based technique. The data suggest that there is an increased detection rate of cervical precancerous lesions with liquid-based cytology, but the number of false positive tests is still high. The specificity of the two tests seems similar, but this cannot be ascertained exactly, because of the fact that follow-up of negative cases is unavailable."

Effect of testing for human papillomavirus as a triage during screening for cervical cancer: observational before and after study (BMJ 2006)

Human papillomavirus DNA in urine samples of women with or without cervical cancer and their male partners compared with simultaneously collected cervical/penile smear or biopsy specimens. (J Clin Virol. 2006) "The case by case matching of HPV positivity and negativity between urine and cervical/penile scrapes or biopsies obtained from women and their male partners demonstrated that the non-invasive urine sampling can be reliably used for screening genital HPV infection in both men and women."

Human papillomavirus typing of invasive cervical cancers in Italy. (Infect Agent Cancer. 2006) "CONCLUSIONS: Our results suggest that HPV 16 has a very high prevalence among women with invasive cervical cancer in Italy; therefore, the use of a prophylactic vaccine for HPV types 16 and 18 could prevent up to 75% of invasive cervical cancers in Italy."

Lymph node metastasis in patients with clinical early-stage cervical cancer: detection with integrated FDG PET/CT. (Radiology. 2006)

Pathways to diagnosis of cervical cancer: screening history, delay in follow up, and smear reading. (BJOG. 2006) "Conclusions The most important factor in women's pathways to a diagnosis of cervical cancer was inadequate screening. While delays in diagnosis could be reduced and laboratory performance improved, priority must be given to improving uptake and frequency of screening."

Prevalence of human papillomavirus types 16 and 18 in cervical adenocarcinoma and its precursors in Scottish patients (International Journal of Gynecological Cancer 2006) "Our findings support that HPV-16, along with HPV-18, are likely to play a significant role in the pathogenesis of cervical adenocarcinomas and that cervical cancer screening strategies that incorporate oncogenic HPV testing, and prophylactic vaccines that target these types, will be beneficial for the reduction of adenocarcinoma and associated glandular precursors."

Systematic evaluation of MRI findings in different stages of treatment of cervical cancer: Potential of MRI on delineation of target, pathoanatomic structures, and organs at risk. (Int J Radiat Oncol Biol Phys. 2006)

The Absolute Risk of Cervical Abnormalities in High-risk Human Papillomavirus–Positive, Cytologically Normal Women Over a 10-Year Period (Cancer Res 2006) "These results indicate that even a single positive HPV test in cytologically negative women is substantially predictive of high-grade CIN and suggest that HC2 testing can help stratify women into different risk categories."

The evaluation of human papillomavirus DNA testing in primary screening for cervical lesions in a large Japanese population (International Journal of Gynecological Cancer 2006) "Notably, HPV DNA testing detected all 45 cases of cervical intraepithelial neoplasia (CIN) 3, while cytologic findings were negative in 6 of these cases. It is of particular interest that CIN was commonly associated with multiple HPV types, while invasive cancers had a single type of HPV. In terms of both sensitivity and positive predictive value in detecting the CIN, HPV DNA testing is superior to cytology. However, most importantly, HPV DNA testing in combination with cytology significantly improved the efficacy to CIN screening."

Usefulness of combining testing for p16 protein and human papillomavirus (HPV) in cervical carcinoma screening. (Gynecol Oncol. 2006) "CONCLUSION: The combination of p16 and HPV detection may be useful in cervical cancer screening to identify high-risk patients requiring early and proper management."

Vaginal self sampling versus physician cervical sampling for HPV among younger and older women. (Sex Transm Infect. 2006) "CONCLUSIONS: There was fair agreement between self collected vaginal and physician collected cervical specimens for detecting carcinogenic HPV in younger and older women. Vaginal sampling for HPV appears to be promising as a primary screening strategy for cervical cancer prevention programmes in low resource settings in developed and developing countries."

Women in a region with high incidence of cervical cancer warrant immediate colposcopy for low-grade squamous intraepithelial lesion on cervical cytology (International Journal of Gynecological Cancer 2006) "In conclusion, in the region with high incidence of cervical cancer, women with LSIL cytology are at increased risk of having underlying high-grade lesions and invasive cancer. Immediate referral for colposcopy is warranted."

Go to the top