Lewy Body Dementia

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Lewy Body Dementia

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Correlation of visual hallucinations with occipital rCBF changes by donepezil in DLB (NEUROLOGY 2006) "Twenty subjects with DLB were treated with donepezil for a 12-week period. Hallucinations attenuated while receiving therapy, whereas occipital rCBF focally increased, suggesting that functional visual association cortex deficits may cause visual hallucinations in patients with DLB."

Dementia with Lewy Bodies (DLB) presenting with catatonic symptoms (Psychogeriatrics 2006)

Dementia with Lewy bodies with and without hallucinations: a clue to different entities? (Int Psychogeriatr. 2006)

Dementia with Lewy Bodies: An Emerging Disease (Am Fam Physician 2006) "Dementia with Lewy bodies appears to be the second most common form of dementia, accounting for about one in five cases. The condition is characterized by dementia accompanied by delirium, visual hallucinations, and parkinsonism. Other common symptoms include syncope, falls, sleep disorders, and depression. The presence of both Lewy bodies and amyloid plaques with deficiencies in both acetylcholine and dopamine neurotransmitters suggests that dementia with Lewy bodies represents the middle of a disease spectrum ranging from Alzheimer's disease to Parkinson's disease."

Differences in neuropathologic characteristics across the Lewy body dementia spectrum. (Neurology. 2006) "CONCLUSION: While there is a clear relationship between the duration of Parkinson disease prior to the onset of dementia and key neuropathologic and neurochemical characteristics, there is a gradation of these differences across the dementia with Lewy bodies/Parkinson disease dementia spectrum and the findings do not support an arbitrary cut-off between the two disorders."

Family History of Dementia: Dementia With Lewy Bodies and Dementia in Parkinson's Disease (J Neuropsychiatry Clin Neurosci 2006)

Lewy body dementia and creativity: Case report. (Neuropsychologia. 2006)

More severe functional impairment in dementia with lewy bodies than Alzheimer disease is related to extrapyramidal motor dysfunction. (Am J Geriatr Psychiatry. 2006) "Conclusion: The nature of functional disability differs between AD and DLB with additional impairments in mobility and self-care in DLB being mainly attributable to extrapyramidal motor symptoms. Consideration of these is important in assessment and management. Activities of daily living scales for use in this population should attribute the extent to which functional disabilities are related to cognitive, psychiatric, or motor dysfunction."

Patients with Lewy body dementia use more resources than those with Alzheimer's disease. (Int J Geriatr Psychiatry. 2006)

Survival and mortality differences between dementia with Lewy bodies vs Alzheimer disease. (Neurology. 2006) " CONCLUSIONS: Dementia with Lewy bodies (DLB) increases the risk of mortality compared with Alzheimer disease (AD), but the two groups did not differ in rate of cognitive decline. The greater risk for noncognitive disease progression for DLB compared with AD suggests clinically meaningful differences for the two disorders."

The Progression of Cognition, Psychiatric Symptoms, and Functional Abilities in Dementia With Lewy Bodies and Alzheimer Disease (Arch Neurol. 2006)

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