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Contaminants

General Information

NEWS:

Cancer risks linked to common pollutant "Growing scientific evidence suggests the most widespread industrial contaminant in drinking water - a solvent used in adhesives, paint and spot removers - can cause cancer in people. . A committee of academy experts said 'a large body of epidemiologic data is available' on TCE showing the chemical is a possible cause of kidney cancer, reproductive and developmental damage, impaired neurological function and autoimmune disease."

Chemical Exposure Creating a "Silent Pandemic" of Neurodevelopmental Disorders? "An online review article published November 8 in the Lancet says environmental exposure to toxic chemicals in utero and in the early stages of life may be creating a "silent pandemic" of neurodevelopmental disorders. … The article cites 5 industrial chemicals, including lead, methylmercury, and polychlorinated biphenyls (PCBs), solvents, and pesticides, that are recognized causes of neurodevelopmental disorders. Exposure to these chemicals during early fetal development can cause brain injury at doses much lower than those affecting adults. Recognition of these risks has given rise to evidence-based programs of prevention, such as the elimination of lead additives in gasoline and house paint. While such initiatives have been effective, most have been initiated only after substantial delays, they point out."

Codex sets new standards on lead, cadmium, aflatoxins

Cumulative Lead Dose and Cognitive Function in Adults: a Review of Studies that Measured Both Blood Lead and Bone Lead

Industrial Chemicals Harms Brains of Children

Lead Exposure and Cardiovascular Disease – a Systematic Review

Lead Levels May Not Be Stringent Enough: Study finds even 'safe' exposures may mean 25% higher risk of death from all causes

Lead poison symptoms may confuse doctors: report

Mercury elevated in hair samples

Study warns of cleaning product risks "When used indoors under certain conditions, many common household cleaners and air fresheners emit toxic pollutants at levels that may lead to health risks, according to a new study by researchers at the University of California, Berkeley, and Lawrence Berkeley National Laboratory."

Teflon chemical likely carcinogen, review finds

The Epidemiology of Lead Toxicity in Adults: Measuring Dose and Consideration of Other Methodological Issues

Whole-Body Lifetime Occupational Lead Exposure and Risk of Parkinson's Disease "Conclusions: These results provide an objective measure of chronic Pb exposure and confirm our earlier findings that occupational exposure to Pb is a risk factor for PD."

Workplace Lead Exposure Brings Long-Term Brain Damage

ARTICLES:

JOURNAL ARTICLES:

Association of Blood Lead and Tibia Lead with Blood Pressure and Hypertension in a Community Sample of Older Adults. (Am J Epidemiol. 2006)

Blood Lead Below 0.48 µmol/L (10 µg/dL) and Mortality Among US Adults (Circulation 2006) "Conclusions--The association between blood lead levels and increased all-cause and cardiovascular mortality was observed at substantially lower blood lead levels than previously reported. Despite the marked decrease in blood lead levels over the past 3 decades, environmental lead exposures remain a significant determinant of cardiovascular mortality in the general population, constituting a major public health problem."

Blood Lead Levels and Death from All Causes, Cardiovascular Disease, and Cancer: Results from the NHANES III Mortality Study. (Environ Health Perspect. 2006) "Conclusion In a nationally representative sample of the U.S. population, blood lead levels as low as 5-9 mug/dL were associated with an increased risk of death from all causes, cardiovascular disease, and cancer."

Brief report: Leptospirosis after flooding of a university campus--Hawaii, 2004. (MMWR Morb Mortal Wkly Rep. 2006)

Cadmium and children: Exposure and health effects. (Acta Paediatr Suppl. 2006)

Chromium risks may have been withheld

Complementary and alternative medicine use among midlife women for reasons including menopause in the United States: 2002. (Menopause. 2006) "RESULTS:: Forty-five percent of women 45 to 57 years of age had used some form of CAM within the last 12 months. Approximately 25% used biologics (e.g., herbs) or mind-body (e.g., biofeedback) modalities, whereas only 15% used body work (massage and chiropractic medicine). Use did not vary by age, but white race, higher education, and residence in the West were associated with increased use. Only 45% of CAM users mentioned its use to a medical provider. The most cited reason for using CAM involved treatment of pain, with only 3% mentioning menopause. However, the odds for use of CAM were almost twice as high for women with menopausal symptoms in the past year compared with women with no symptoms …"

Contaminants, diet, plasma fatty acids and smoking in Greenland 1999-2005. (Sci Total Environ. 2006) "CONCLUSION: The main predictors of high contaminant levels in Greenland were age, district, male gender, smoking and high plasma n-3/n-6 ratio as a marker of high dietary intake of local marine mammals."

Co-consumption of selenium and vitamin E altered the reproductive and developmental toxicity of methylmercury in rats. (Neurotoxicol Teratol. 2006)

Deaths associated with hypocalcemia from chelation therapy--Texas, Pennsylvania, and Oregon, 2003-2005. (MMWR Morb Mortal Wkly Rep. 2006) "This report describes three deaths associated with chelation-therapy--related hypocalcemia that resulted in cardiac arrest. Several drugs are used in the treatment of lead poisoning, including edetate disodium calcium (CaEDTA), dimercaperol (British anti-Lewisite), D-penicillamine, and meso-2,3-dimercaptosuccinic acid (succimer).Health-care providers who are unfamiliar with chelating agents and are considering this treatment for lead poisoning should consult an expert in the chemotherapy of lead poisoning. Hospital pharmacies should evaluate whether continued stocking of Na2EDTA is necessary, given the established risk for hypocalcemia, the availability of less toxic alternatives, and an ongoing safety review by the Food and Drug Administration (FDA). Health-care providers and pharmacists should ensure that Na2EDTA is not administered to children during chelation therapy."

Environmental exposure to cadmium and risk of cancer: a prospective population-based study. (Lancet Oncol. 2006)

Findings of and treatment for high levels of mercury and lead toxicity in ground zero rescue and recovery workers and lower Manhattan residents. (Explore (NY). 2006) "Of those tested for heavy metal toxicity, using a challenge urine test, 85% had excessively high levels of lead and mercury. Chelation treatment using dimercaptuosuccinic acid (DMSA), a Food and Drug Administration (FDA)-approved sulfur compound, was the primary treatment prescribed. After three to four months of treatment, the first cohort of 100 individuals reported significant (greater than 60%) improvement in all symptoms."

Inorganic arsenic in cooked rice and vegetables from Bangladeshi households. (Sci Total Environ. 2006) "Given the arsenic levels measured in food and water and consumption of these items, cooked rice and vegetables are a substantial exposure pathway for inorganic arsenic. Intervention strategies must consider all sources of dietary arsenic intake."

Knee osteonecrosis due to lead poisoning: Case report and review of the literature. (Med Sci Monit. 2006)

Lead Exposure and Spine Bone Mineral Density. (J Occup Environ Med. 2006) "CONCLUSIONS:: Blood lead may adversely affect bone mineral density."

Mercury content in commercial pelagic fish and its risk assessment in the Western Indian Ocean. (Sci Total Environ. 2006) "The muscular Hg levels presented here suggest that consumers of fish originating from theWestern Indian Ocean should limit themselves to one Swordfish based meal per week, or one fish meal a day if they choose to eat tuna or Common Dolphinfish."

Mercury toxicity presenting as Chronic Fatigue, memory impairment and depression: Diagnosis, treatment, susceptibility, and outcomes in a New Zealand general practice setting (1994-2006). (Neuro Endocrinol Lett. 2006) "Removal of amalgam mercury fillings when combined with appropriate treatment resulted in a significant symptom reduction (p< 0.001) to levels reported by healthy subjects."

Pesticides and their Metabolites in the Homes and Urine of Farmworker Children Living in the Salinas Valley, CA. (J Expo Sci Environ Epidemiol. 2006) "Pesticides were detected more frequently in house dust, surface wipes, and clothing than other media, with chlorpyrifos, diazinon, chlorthal-dimethyl, and cis- and trans-permethrin detected in 90% to 100% of samples. . Several OP pesticides, as well as 4,4'-DDE, atrazine, and dieldrin were detected in the food samples."

Reduced Intellectual Development in Children with Prenatal Lead Exposure (Environ Health Perspect 2006) "Conclusions: Lead exposure around 28 weeks gestation is a critical period for later child intellectual development, with lasting and possibly permanent effects. There was no evidence of a threshold ; the strongest lead effects on IQ occurred within the first few micrograms of BPb."

The Estrogenic Effect of Bisphenol A Disrupts Pancreatic beta-Cell Function In Vivo and Induces Insulin Resistance. (Environ Health Perspect. 2006)

The Impact of Early Childhood Lead Exposure on Brain Organization: A Functional Magnetic Resonance Imaging Study of Language Function (PEDIATRICS 2006)

The toxicology of mercury and its chemical compounds. (rit Rev Toxicol. 2006)

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