Chronic Fatigue Syndrome

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Chronic Fatigue Syndrome

General Information

NEWS:

Severe fatigue common in adolescent girls "One in five adolescent girls may suffer from severe fatigue, according to a new survey."

ARTICLES:

Chronic Fatigue Syndrome: When Exercise Makes You Feel Worse

The Basics of Chronic Fatigue Syndrome

JOURNAL ARTICLES:

Chronic fatigue syndrome. (J Clin Virol. 2006) "Chronic fatigue syndrome (CFS) is thought to have a worldwide prevalence of 0.4-1% with approximately 240,000 patients in the UK. Diagnosis is based on clinical criteria and critically depends on exclusion of other physical and psychiatric diseases. Studies of pathogenesis have revealed immune system abnormalities and chronic immune activation, dysfunction of the hypothalamic-pituitary-adrenal (HPA) axis, brain abnormalities, evidence of emotional stress (comprising host aspects) and evidence of exogenous insults, for example, various microbial infections (Epstein-Barr virus, enteroviruses, parvovirus B19, Coxiella burnetii and Chlamydia pneumoniae), vaccinations and exposure to organophosphate chemicals and other toxins (comprising environmental aspects). Emotional stress appears to be very important as it reduces the ability of the immune system to clear infections, it's presence has been shown to determine whether or not an individual develops symptoms upon virus infection, and it leads to activation of the HPA axis."

Chronic fatigue syndrome. (Lancet. 2006)

Chronic musculoskeletal pain in patients with the chronic fatigue syndrome: A systematic review. (Eur J Pain. 2006) "CONCLUSIONS: The results from the systematic review highlight the clinical importance of chronic pain in CFS, but only few studies addressing the aetiology or treatment of chronic pain in CFS are currently available."

Cognitive Dysfunction Relates to Subjective Report of Mental Fatigue in Patients with Chronic Fatigue Syndrome. (Neuropsychopharmacology. 2006)

Decreased muscle blood flow in fibromyalgia patients during standardised muscle exercise: a contrast media enhanced colour Doppler study. (Eur J Pain. 2006)

Diurnal excretion of urinary cortisol, cortisone, and cortisol metabolites in chronic fatigue syndrome. (J Psychosom Res. 2006)

Fatigue Intervention by Nurses Evaluation - The FINE Trial. A randomised controlled trial of nurse led self-help treatment for patients in primary care with chronic fatigue syndrome: study protocol. [ISRCTN 74156610]. (BMC Med. 2006) "BACKGROUND: Chronic fatigue syndrome, also known as ME (CFS/ME), is a condition characterised primarily by severe, disabling fatigue, of unknown origin, which has a poor prognosis and serious personal and economic consequences. Evidence for the effectiveness of any treatment for CFS/ME in primary care, where most patients are seen, is sparse. Recently, a brief, pragmatic treatment for CFS/ME, based on a physiological dysregulation model of the condition, was shown to be successful in improving fatigue and physical functioning in patients in secondary care. The treatment involves providing patients with a readily understandable explanation of their symptoms, from which flows the rationale for a graded rehabilitative plan, developed collaboratively with the therapist."

Fatigue: a practical approach to diagnosis in primary care (CMAJ 2006)

Generalized joint hypermobility is more common in chronic fatigue syndrome than in healthy control subjects. (J Manipulative Physiol Ther. 2006)

Increase of free Mg2+ in the skeletal muscle of chronic fatigue syndrome patients. (Dyn Med. 2006)

Nutrient intake is unrelated to nutrient status in patients with chronic fatigue syndrome (Journal of Nutritional & Environmental Medicine 2006)

Post-infective and chronic fatigue syndromes precipitated by viral and non-viral pathogens: prospective cohort study. (MJ. 2006) "CONCLUSIONS: A relatively uniform post-infective fatigue syndrome persists in a significant minority of patients for six months or more after clinical infection with several different viral and non-viral micro-organisms. Post-infective fatigue syndrome is a valid illness model for investigating one pathophysiological pathway to chronic fatigue syndrome."

Reduced levels of antiinflammatory cytokines in patients with chronic widespread pain. (Arthritis Rheum. 2006) "CONCLUSION: Chronic widespread pain is associated with a lack of antiinflammatory and analgesic Th2 cytokine activity, which may contribute to its pathogenesis."

The influence of aerobic fitness and fibromyalgia on cardiorespiratory and perceptual responses to exercise in patients with chronic fatigue syndrome. (Arthritis Rheum. 2006)

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