Neuropathy

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Neuropathy

General Information

NEWS:

ARTICLES:

American Diabetes Association Reviews Diabetic Neuropathies

Peripheral Neuropathy With Impaired Glucose Tolerance " … many nondiabetic patients with CIAP have disturbed glucose metabolism as evidenced by impaired fasting glucose (IFG) …"

JOURNAL ARTICLES:

Alcoholic neuropathy. (Current Opinion in Neurology. 2006) "Summary: Nutritional deficiency as well as the direct neurotoxic effects of ethanol or its metabolites can cause alcoholic neuropathy. Although clinicopathologic features of the pure form of alcoholic neuropathy are uniform, they show extensive variation when thiamine deficiency is present."

Autoimmune optic neuropathy. (Curr Neurol Neurosci Rep. 2006)

Axon loss is an important determinant of weakness in multifocal motor neuropathy. (J Neurol Neurosurg Psychiatry. 2006) "BACKGROUND: Multifocal motor neuropathy (MMN) is characterised by asymmetrical weakness and muscle atrophy, in the arms more than the legs, without sensory loss. Despite a beneficial response to treatment with intravenous immunoglobulins (IVIg), weakness is slowly progressive. Histopathological studies in MMN revealed features of demyelination and axon loss. . CONCLUSION: Axon loss occurs frequently in MMN and pathogenic mechanisms leading to axonal degeneration may play an important role in the outcome of the neurological deficit in patients with MMN."

Chronic inflammatory demyelinating polyneuropathy. (Neuromuscul Disord. 2006) "Chronic inflammatory demyelinative polyneuropathy (CIDP) is an acquired neuropathy, presumably of immunological origin. Its clinical presentation and course are extremely variable. CIDP is one of the few peripheral neuropathies amenable to treatment."

Diabetic neuropathy. (Postgrad Med J. 2006)

Diabetic peripheral neuropathic pain: clinical and quality-of-life issues. (Mayo Clin Proc. 2006) "Diabetic peripheral neuropathy (DPN) is estimated to be present in 50% of people living with diabetes mellitus (DM). Comorbidities of DM, such as macrovascular and microvascular changes, also Interact with DPN and affect its course. In patients with DM, DPN Is the leading cause of foot ulcers, which in turn are a major cause of amputation in the United States. Although most patients with DPN do not have pain, approximately 11% of patients with DPN have chronic, painful symptoms that diminish quality of life, disrupt sleep, and can lead to depression."

Early Involvement of the Spinal Cord in Diabetic Peripheral Neuropathy (Diabetes Care 2006) "We have recently reported a significant reduction in spinal cord cross-sectional area at the stage of clinically detectable DPN. In this study, we investigated whether spinal cord atrophy occurs in early (subclinical) DPN."

Entrapment neuropathies of the shoulder and elbow in the athlete. (Clin Sports Med. 2006)

Exercise training can modify the natural history of diabetic peripheral neuropathy. (J Diabetes Complications. 2006) "CONCLUSIONS: This study suggests, for the first time, that long-term aerobic exercise training can prevent the onset or modify the natural history of DPN."

Guillain-Barre syndrome. (Neurol Sci. 2006)

HIV Peripheral Neuropathy: Pathophysiology and Clinical Implications. (AACN Clin Issues. 2006)

Hypertension and Sensorimotor Peripheral Neuropathy in Type 2 Diabetes. (Eur Neurol. 2006)

Intermediate forms of charcot-marie-tooth neuropathy: a review. (Neuromolecular Med. 2006)

Multifocal axonal polyneuropathy in celiac disease (NEUROLOGY 2006)

Neuropathic pain: a practical guide for the clinician. (CMAJ. 2006) "Neuropathic pain, caused by various central and peripheral nerve disorders, is especially problematic because of its severity, chronicity and resistance to simple analgesics. The condition affects 2%-3% of the population, is costly to the health care system and is personally devastating to the people who experience it. The diagnosis of neuropathic pain is based primarily on history (e.g., underlying disorder and distinct pain qualities) and the findings on physical examination (e.g., pattern of sensory disturbance); however, several tests may sometimes be helpful. . Although many patients with neuropathic pain pursue complementary and alternative treatments, rigorous evidence supporting efficacy of nondrug therapy is limited. Some reports suggest benefits of conservative interventions such as exercise,76 transcutaneous electrical nerve stimulation,77 percutaneous electrical nerve stimulation,78 graded motor imagery79 and cognitive behavioural therapy or supportive psychotherapy. . No single drug works for all neuropathic pain states, and given the diversity of pain mechanisms, patient responses and diseases, treatment must be individualized. Other than analgesia, factors to consider when individualizing therapy include tolerability, other benefits (e.g., improved sleep, mood and quality of life), low likelihood of serious adverse events and cost-effectiveness to the patient and the health care system.61 The evidence-based approach presented here may require revision as newer treatments and clinical evidence become available. . For some neuropathic pain syndromes, available treatments are tolerable and afford meaningful relief to a considerable proportion of patients. Nevertheless, many patients report intractable and severe pain, and better treatment strategies are desperately needed.132"

Painful diabetic neuropathy: a cross-sectional survey of health state impairment and treatment patterns. (J Diabetes Complications. 2006)

Pathological mechanisms involved in diabetic neuropathy: can we slow the process? (Curr Opin Investig Drugs. 2006) "Diabetic polyneuropathy (DPN) is the most common late diabetic complication, and is more frequent and severe in the type 1 diabetic population. Currently, no effective therapy exists to prevent or treat this complication. Hyperglycemia remains a major therapeutic target when dealing with DPN in both type 1 and type 2 diabetes, and should be supplemented by aldose reductase inhibition and antioxidant treatment. However, in the past few years, preclinical and clinical data have indicated that factors other than hyperglycemia contribute to DPN, and these factors account for the disproportionality of prevalence of DPN between the two types of diabetes."

Peripheral Insensate Neuropathy--A Tall Problem for US Adults? (Am J Epidemiol. 2006) "The authors conclude that body height is an important correlate of peripheral insensate neuropathy. This association largely accounts for the difference in peripheral insensate neuropathy prevalence between men and women. Height may help health-care providers to identify persons at high risk of peripheral insensate neuropathy."

Peripheral neuropathies of the median, radial, and ulnar nerves: MR imaging features. (Radiographics. 2006)

Peripheral neuropathy in an outpatient cohort of patients with Sjogren's syndrome. (Muscle Nerve. 2006)

Peripheral neuropathy in primary sjogren syndrome: a population-based study. (Arch Neurol. 2006)

[Peripheral neuropathy in the elderly.] (Psychol Neuropsychiatr Vieil. 2006) "Peripheral neurologic deficits are commonly found during physical examination of older patients. Losses of vibratory sensation in the lower extremities and ankle reflexes are so common that they are often listed in geriatric textbooks as normal physical findings in very old people."

Pupil findings in a consecutive series of 150 cases of generalised autonomic neuropathy. (J Neurol Neurosurg Psychiatry. 2006)

Recent advances in hereditary sensory and autonomic neuropathies. (urr Opin Neurol. 2006)

Restless legs syndrome and polyneuropathy. (Mov Disord. 2006)

Role of magnetic resonance imaging in entrapment and compressive neuropathy-what, where, and how to see the peripheral nerves on the musculoskeletal magnetic resonance image: part 2. Upper extremity. (Eur Radiol. 2006) "The common sites of nerve entrapment of the upper extremity are as follows: the brachial plexus of the thoracic outlet; axillary nerve of the quadrilateral space; radial nerve of the radial tunnel; ulnar nerve of the cubital tunnel and Guyon's canal; median nerve of the pronator syndrome, anterior interosseous nerve syndrome, and carpal tunnel syndrome."

Sleep Impairment in Patients With Painful Diabetic Peripheral Neuropathy. (lin J Pain. 2006) "DISCUSSION: Painful DPN is associated with considerable sleep impairment. Given the recognized association between sleep impairment, type 2 diabetes and metabolic and affective disturbance, and the known adverse impact of affective disturbance on diabetes self-care, addressing these features-pain, sleep, and affective disturbance-is an important aspect of care for patients with painful DPN."

Small-fiber neuropathy: answering the burning questions. (Sci Aging Knowledge Environ. 2006) "Small-fiber neuropathy is a peripheral nerve disease that most commonly presents in middle-aged and older people, who develop burning pain in their feet. Although it can be caused by disorders of metabolism such as diabetes, chronic infections (such as with human immunodeficiency virus), genetic abnormalities, toxicity from various drugs, and autoimmune diseases, the cause often remains a mystery because standard electrophysiologic tests for nerve injury do not detect small-fiber function."

Sural neuropathy: Etiologies and predisposing factors. (Muscle Nerve. 2006)

The dominantly inherited motor and sensory neuropathies: Clinical and molecular advances. (Muscle Nerve. 2006)

The natural history of chronic painful peripheral neuropathy in a community diabetes population. (Diabet Med. 2006) "CONCLUSIONS: The neuropathic pain of CPDN can resolve completely over time in a minority (23%). In those in whom painful neuropathic symptoms had persisted over 5 years, no significant improvement in pain intensity was observed. Despite the improvement in treatment modalities for chronic pain in recent years, patients with CPDN continue to be inadequately treated."

The Prevalence, Severity, and Impact of Painful Diabetic Peripheral Neuropathy in Type 2 Diabetes (Diabetes Care 2006)

The Relationship Among Pain, Sensory Loss, and Small Nerve Fibers in Diabetes (Diabetes Care 2006)

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