Parkinson's Disease

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Parkinson's Disease

Diagnosis, Imaging, and Screening

NEWS:

Only specialists should diagnose Parkinson's disease "Family doctors should refer patients with suspected Parkinson's disease promptly to a specialist rather than try and diagnose it themselves, recommends guidance on the diagnosis and management of the disease, published this week . Patients with suspected mild disease should be seen within six weeks, while new referrals with more advanced disease and more complex problems should be given a specialist appointment within two weeks."

ARTICLES:

JOURNAL ARTICLES:

Diagnosis and treatment of Parkinson disease: molecules to medicine. (J Clin Invest. 2006)

Hippocampal neuron and glial cell numbers in Parkinson's disease-A stereological study. (Hippocampus. 2006) "We did not find significant differences in cell numbers or volumes in PD brains when compared with control subjects. Our results thus indicate that hippocampal atrophy and cell loss are not necessarily involved in the memory impairment and dementia observed in PD."

MR imaging of middle cerebellar peduncle width: differentiation of multiple system atrophy from Parkinson disease. (Radiology. 2006) "PURPOSE: To prospectively assess if middle cerebellar peduncle (MCP) atrophy, evaluated at magnetic resonance (MR) imaging, can help differentiate multiple system atrophy (MSA) from Parkinson disease (PD). . CONCLUSION: Measurement of MCP width on MR images may be useful for distinguishing patients with MSA from those with PD."

Practice Parameter: Diagnosis and prognosis of new onset Parkinson disease (an evidence-based review). Report of the Quality Standards Subcommittee of the American Academy of Neurology. (Neurology. 2006)

Subjective Complaints Precede Parkinson Disease (Arch Neurol. 2006) "Conclusions Subjective complaints of stiffness, tremors, and imbalance are associated with an increased risk of future Parkinson disease and may reflect early effects of dopamine shortage, even when standard neurological testing cannot yet demonstrate any motor symptoms."

The diagnosis of Parkinson's disease. (Lancet Neurol. 2006)

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