Parkinson's Disease

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Parkinson's Disease

Risk Factors

NEWS:

Allergies Linked to Parkinson's Disease

Banned Pesticide May Be Linked to Parkinson's Disease "A now-banned pesticide that still lingers in the environment could be damaging human brain cells and prompting the onset of Parkinson's disease, a new study suggests. Animal and human cadaver studies appear to link exposure to dieldrin, an organochlorine pesticide, with Parkinson's disease, researchers say."

Head injury may increase risk of Parkinson's: study "A new study supports the hypothesis that head injury increases the risk of Parkinson's disease (PD). In the study, which included twin pairs in which one twin had PD and the other did not, head injuries of mild-to-moderate severity were associated with a threefold increased risk of PD developing several decades later."

Hunting Down Parkinson's Risks

Lingering Pesticides Linked to Parkinson's "The team found evidence that free radicals had damaged certain brain cells that produce dopamine, a neurotransmitter that plays a key role in Parkinson's disease. People who sustain damage to these same brain cells start to develop the symptoms of Parkinson's, such as a shuffling walk, Miller says. He believes Parkinson's is kicked off by a combination of factors, including genes, but then the disease speeds up as a result of exposure to pesticides such as dieldrin. . Ascherio says pesticides still in use, such as those for a home garden, also might pose some risk to these sensitive brain cells."

Parkinson's disease tied to allergic rhinitis "Adults with allergic rhinitis are nearly three times as likely to develop Parkinson's disease (PD) later in life, compared with those who do not have allergies …"

Pesticide Exposure and Self-reported Parkinson's Disease in the Agricultural Health Study. (Am J Epidemiol. 2006) "This study suggests that exposure to certain pesticides may increase PD risk."

Pesticide Use Ups Parkinson's in Men

Study Links Parkinson's to Pesticide

Study Shows Impact of Parkinson's Gene "Researchers report that inheriting even one copy of a mutated gene known to cause Parkinson's disease might trigger early symptoms."

Whole-Body Lifetime Occupational Lead Exposure and Risk of Parkinson's Disease "Conclusions: These results provide an objective measure of chronic Pb exposure and confirm our earlier findings that occupational exposure to Pb is a risk factor for PD."

ARTICLES:

JOURNAL ARTICLES:

Associations between family history of Parkinson's disease and dementia and risk of dementia in Parkinson's disease: A community-based, longitudinal study. (Mov Disord. 2006)

Body mass index and the risk of Parkinson disease (NEUROLOGY 2006) "Conclusion: Body mass index is associated with a risk of Parkinson disease. The effect is graded and independent of other risk factors."

Familial risks of hospitalization for Parkinson's disease in first-degree relatives: a nationwide follow-up study from Sweden. (Neurogenetics. 2006) "In conclusion, the findings of the present study suggest that genetic factors are important in early- (age 50 years) onset PD, and that shared environmental factors during childhood or recessive effects may partly be important for familial aggregation of the disease."

Head injury and Parkinson's disease risk in twins. (Ann Neurol. 2006) "INTERPRETATION: Our results suggest that mild-to-moderate closed head injury may increase PD risk decades later."

Herbicide exposure modifies GSTP1 haplotype association to Parkinson onset age: The GenePD Study (NEUROLOGY 2006) " Conclusions: Herbicide exposure may be an effect modifier of the relation between glutathione S-transferase pi gene polymorphisms and onset age in familial PD."

Paraquat exposure as an etiological factor of Parkinson's disease. (Neurotoxicology. 2006)

Parkinson's disease and genetics. (Neurologist. 2006)

Pesticide exposure on southwestern Taiwanese with MnSOD and NQO1 polymorphisms is associated with increased risk of Parkinson's disease. (Clin Chim Acta. 2006) " CONCLUSION: Susceptible variants of MnSOD and NQO1 genes may interact with occupational pesticide exposure to increase PD risk in southwestern Taiwanese."

Pesticides and Parkinson's Disease--Is There a Link? (Environ Health Perspect 2006)

Serum Cholesterol Levels and the Risk of Parkinson's Disease (American Journal of Epidemiology 2006)

The number of pregnancies is a risk factor for Alzheimer's disease (European Journal of Neurology 2006) "Within the AD cases, the number of lifetime pregnancies is related to an earlier onset of the disease. As previously reported, we confirmed that the educational level is a protective factor and that major head trauma represents a risk factor in developing AD. The higher number of pregnancies and a less frequency of nulliparous women, indirectly relate the AD group to a higher estro-progestinic exposure. These findings suggest that it is the increase of progesterone or estrogens level - and not the estrogens decrease, as previously indicated by other authors - that could play a role in the Alzheimer's pathology."

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