Schizophrenia

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Schizophrenia

General Information

NEWS:

Music may ease symptoms of schizophrenia "The patients in the study received standard therapy alone or with the musical component, which consisted of 8 to 12 music sessions. They were encouraged to express themselves with a range of musical instruments. After measuring the symptoms in the patients, Crawford and his team found greater improvements in the music therapy group."

Olfactory Ability May Predict Outcome of Psychotic Disorders "An impaired ability to correctly identify various scents is seen in psychotic patients at risk for persistent negative and disorganized/cognitive symptoms, according to a new report."

‘Schizophrenia’ should be dropped, experts say " ... suggested replacing the term schizophrenia with the label dopamine dysregulation disorder, which he said more accurately reflects what is happening in the brain of someone who is psychotic."

ARTICLES:

Psychosis fact file

JOURNAL ARTICLES:

Association of Schizophrenia and Autoimmune Diseases: Linkage of Danish National Registers (American Journal of Psychiatry 2006) "RESULTS: A history of any autoimmune disease was associated with a 45% increase in risk for schizophrenia. Nine autoimmune disorders had higher prevalence rates among patients with schizophrenia than among comparison subjects (crude incidence rate ratios ranging from 1.9 to 12.5), and 12 autoimmune diseases had higher prevalence rates among parents of schizophrenia patients than among parents of comparison subjects (adjusted incidence rate ratios ranging from 1.3 to 3.8). Thyrotoxicosis, celiac disease, acquired hemolytic anemia, interstitial cystitis, and Sjögren's syndrome had higher prevalence rates among patients with schizophrenia than among comparison subjects and also among family members of schizophrenia patients than among family members of comparison subjects."

[Epidemiology of schizophrenic disorders.] (Presse Med. 2006) "Genetic factors affect vulnerability or predisposition to schizophrenia. Accordingly a first-degree relative of a schizophrenic patient has a risk 5 to 10 times higher of developing the disease than does a person with no affected relatives. This risk is not one of simple Mendelian transmission but rather vulnerability, which implies the intervention of several genes. Some environmental factors have also been identified, including exposure to influenza virus during the gestational period (between the 4th and 7th month of pregnancy). This finding reinforces the hypothesis of a neurodevelopmental origin of schizophrenia. Finally, among other associated factors, regular cannabis use appears to quadruple the risk of disease."

Estrogen, Cognitive Function and Negative Symptoms in Female Schizophrenia. (Neuropsychobiology. 2006) "These results suggest that for schizophrenic women of reproductive age, lower levels of estrogen are associated with more severe negative symptomatology as well as reduced performance in cognitive function, especially verbal performance and executive functioning."

Folate and long-chain polyunsaturated fatty acids in psychiatric disease (The Journal of Nutritional Biochemistry 2996)

Forty-two-years later: the outcome of childhood-onset schizophrenia. (J Neural Transm. 2006)

High rates of comorbidity are found in childhood-onset schizophrenia. (Schizophr Res. 2006) "RESULTS: Eighty-one (99%) of the children with schizophrenia or schizoaffective disorder had at least one comorbid psychiatric illness: attention deficit hyperactivity disorder (84%), oppositional defiant disorder (43%), depression (30%), and separation anxiety disorder (25%) were the most common comorbid conditions identified."

Hypothalamic Abnormalities in Schizophrenia: Sex Effects and Genetic Vulnerability. (Biol Psychiatry. 2006)

Impairments in frontal cortical {gamma} synchrony and cognitive control in schizophrenia. (Proc Natl Acad Sci U S A. 2006)

Increase in schizophrenia incidence rates: findings in a Canadian cohort born 1975-1985. (Soc Psychiatry Psychiatr Epidemiol. 2006)

Long-term course of cognitive impairment in schizophrenia. (Br J Psychiatry. 2006)

Pain insensitivity in schizophrenia: trait or state marker? (J Psychiatr Pract. 2006) "CONCLUSIONS: Pain insensitivity in individuals with schizophrenia, which is associated with increased morbidity and mortality, is poorly understood. It is possible that pain insensitivity might serve as a prodromal predictor of susceptibility for schizophrenia."

Preventing clinical deterioration in the course of schizophrenia: the potential for neuroprotection. (CNS Spectr. 2006)

Psychosis among "healthy" siblings of schizophrenia patients. (BMC Psychiatry. 2006) "Thirty (16%) siblings received a diagnosis of psychotic disorder in the interview. 14 siblings had had psychotic symptoms already before 1991, while 16 developed psychotic symptoms during the follow-up. Over half of the siblings (n=99, 54%) had a lifetime diagnosis of any mental disorder in the interview."

Schizophrenia and Bipolar Disorder: Differences and Overlaps (Curr Opin Psychiatry. 2006)

Schizophrenia with prominent catatonic features ('catatonic schizophrenia').II. Factor analysis of the catatonic syndrome. (Prog Neuropsychopharmacol Biol Psychiatry. 2006)

Sleep disturbances in childhood-onset schizophrenia. (Schizophr Res. 2006)

[Smoking and Schizophrenia: Where is the Biological Connection?] (Turk Psikiyatri Derg. 2006) "OBJECTIVE: Patients with psychiatric disorders have a higher incidence of smoking than the general population. In particular, the rate of smoking among patients with schizophrenia has been found to be between two and three times in the general population in western countries. This paper reviews the biological factors that might be contributing to the high rate of smoking among patients with schizophrenia and examines the interaction between nicotine and neurobiological disturbances observed in schizophrenia."

The n-3 polyunsaturated fatty acid/dopamine hypothesis of schizophrenia. (Prog Neuropsychopharmacol Biol Psychiatry. 2006)

Total antioxidant response in patients with schizophrenia. (Psychiatry Clin Neurosci. 2006) "There is a large amount of convincing data demonstrating that reactive oxygen species (ROS) are involved in initiation and development of many different forms of neuropsychiatric disorders. The levels of oxidants and antioxidants in schizophrenia have been evaluated. . he present study further emphasizes the growing consideration that free radical damage may have an important etiopathogenetic role on the development of schizophrenia and suggests that decreased plasma total antioxidant levels may be related to the progression of illness."

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