Tremor

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Tremor

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JOURNAL ARTICLES:

Benign tremulous parkinsonism. (Arch Neurol. 2006) "CONCLUSIONS: Benign tremulous parkinsonism may be a distinct clinical entity characterized by tremor predominance plus minimal progression of other aspects of parkinsonism. The tremor is often not very responsive to levodopa therapy. In this series, most patients had immediate family members with a diagnosis of tremor or PD."

[Clinical, functional and quality of life differences in patients of different gender with essential tremor.] (Neurologia. 2006)

CYP2C19 Polymorphism and Risk for Essential Tremor. (ur Neurol. 2006)

Differences in multiple segment tremor dynamics between young and elderly persons. ( Gerontol A Biol Sci Med Sci. 2006)

Elderly-onset essential tremor is associated with dementia. (Neurology. 2006) "CONCLUSIONS: Older-onset essential tremor (ET) was associated with dementia. Prospective studies are required to elucidate the association between ET and dementia."

Essential Tremor Associated With Pathologic Changes in the Cerebellum (Arch Neurol. 2006)

Essential tremor: Predictors of disease progression in a clinical cohort. (J Neurol Neurosurg Psychiatry. 2006) " . predictive factors associated with increased tremor severity at the initial clinic visit included an older age, a longer disease duration, use of movement disorder medication, and the presence of voice tremor . The significant factors associated with an increase in tremor severity from the initial clinic visit to the last follow-up included asymmetrical tremor ratings, unilateral initial tremor onset, and a longer follow-up duration."

Essential tremor--the most common movement disorder in older people. (Age Ageing. 2006) "Essential tremor (ET) affects approximately 4% of the population above 65 years of age. The traditional view that ET is a familial mono-symptomatic disorder with a benign prognosis has recently been challenged, as it is now known to be a progressive and clinically heterogeneous condition with sporadic and familial forms."

Exploring the relationship between essential tremor and Parkinson's disease. (Parkinsonism Relat Disord. 2006)

Familial essential tremor with apparent autosomal dominant inheritance: Should we also consider other inheritance modes? (Mov Disord. 2006)

Frontal Functions in Young Patients With Essential Tremor: A Case Comparison Study (J Neuropsychiatry Clin Neurosci 2006) "Essential tremor (ET) is classified as a pure motor system disease. It has been previously reported that impairments in cognitive functions can be associated with ET. The authors assessed cognitive functions in a relatively young patient group with ET and comparison subjects. . Conclusions suggest that the subclinical cognitive deficits characterized by visuospatial and verbal memory impairments and executive dysfunction may be a clinical feature of ET, and the cerebello-thalamo-frontal network may play a role in the pathophysiology of this disorder."

Functional mobility and postural control in essential tremor. (Arch Phys Med Rehabil. 2006) "CONCLUSIONS: Participants with ET show reduced functional mobility, especially those with head tremor."

Head tremor in Parkinson's disease. (Mov Disord. 2006)

Intention tremor of the head in patients with essential tremor. (Mov Disord. 2006) "These observations provide further support for the evolving view that the cerebellum may be involved in ET."

Jaw tremor: Prevalence and clinical correlates in three essential tremor case samples. (Mov Disord. 2006) "The association in our study between jaw tremor and rest tremor, along with the published observation that jaw tremor can occur in Parkinson's disease (PD), raises the question whether jaw tremor in ET is a marker for subsequent conversion to PD."

Kinetic tremor in Parkinson's disease - an underrated symptom. (J Neural Transm. 2006)

Neuropathologic findings in essential tremor (NEUROLOGY 2006)

Nonparkinsonism movement disorders in the elderly. (Consult Pharm. 2006) "DATA SYNTHESIS: Essential tremor is most commonly manifested as a postural or action tremor of the upper extremities. Midline regions such as the head and voice are also commonly affected. Based on review of the literature, propranolol and primidone are the current pharmacologic mainstays for treating essential tremor of the upper extremities. The choice of agent depends on patient-specific factors such as underlying medical conditions. Other agents with demonstrated efficacy include gabapentin and topiramate. Benzodiazepines are effective adjunctive agents, but should be utilized judiciously in the elderly. Botulinum toxin is effective for essential tremor of the voice and head. Surgery is very effective, but may not be appropriate in the frail elderly and should be avoided in the presence of cognitive impairment."

Parkinsonism and essential tremor in a family with pseudo-dominant inheritance of PARK2: An FP-CIT SPECT study. (Mov Disord. 2006) "We report a family with 5 affected individuals manifesting either essential tremor (ET), Parkinsonism, or both, consistent with pseudo-dominant inheritance of PARK2."

Pesticides and Parkinson's disease--is there a link? (Environ Health Perspect. 2006) "Parkinson's disease (PD) is an idiopathic disease of the nervous system characterized by progressive tremor, bradykinesia, rigidity, and postural instability. It has been postulated that exogenous toxicants, including pesticides, might be involved in the etiology of PD. . From the epidemiologic literature, there does appear to be a relatively consistent relationship between pesticide exposure and PD. This relationship appears strongest for exposure to herbicides and insecticides, and after long durations of exposure. Toxicologic data suggest that paraquat and rotenone may have neurotoxic actions that potentially play a role in the development of PD, with limited data for other pesticides. However, both the epidemiology and toxicology studies were limited by methodologic weaknesses."

Population-based case-control study of cognitive function in essential tremor. (Neurology. 2006) "CONCLUSIONS: In a population-based sample of largely untreated patients with essential tremor, cases performed more poorly on formal neuropsychological testing than did their counterparts without tremor. A complaint of forgetfulness was also marginally more common in patients with essential tremor."

Psychogenic tremor: long-term outcome. (CNS Spectr. 2006)

Report from a U.S. conference on essential tremor. (Mov Disord. 2006)

Rest and postural tremors in patients with Parkinson's disease. (Brain Res Bull. 2006) "The present results suggest that neural mechanisms involved in PD rest tremor do remain active in the postural condition, even in patients with mild tremor."

Sequelae of fume exposure in confined space welding: A neurological and neuropsychological case series. (Neurotoxicology. 2006) "Among the 43 eligible welders, 11 cases of manganism were identified presenting with the following symptoms: sleep disturbance, mood changes, bradykinesia, headaches, sexual dysfunction, olfaction loss, muscular rigidity, tremors, hallucinations, slurred speech, postural instability, monotonous voice, and facial masking."

Side and type of motor symptom influence cognition in Parkinson's disease. (Mov Disord. 2006) "These findings suggest an intricate relationship between motor symptom and side of disease onset and it is the combination of these factors that may influence the disease course and extent of cognitive deterioration. Furthermore, patients who develop tremor on the right side of their body represent a distinct subgroup of PD patients who exhibit relative sparing of cognitive function."

Study of possible factors associated with age of onset in essential tremor. (Mov Disord. 2006) " … age of tremor onset was strongly associated with family history of tremor (P < 0.001). The familial form of ET is characterized by an earlier age of onset than the sporadic form."

Tremor in patients with migraine. (Headache. 2006) "Background.-It has been suggested that patients with migraine are at a higher risk of developing essential tremor (ET). In addition, it was shown that patients with migraine are at higher risk of subclinical vascular infarcts in the cerebellum, a structure believed to be implicated in ET. . Results.-All tremor characteristics described above were very similar between the migraine group and controls. These results were supported by the lack of correlation between tremor characteristics and the number of years of experiencing migraine (ranging from 3 to 41 years; mean: 20 +/- 10). Patients with aura (N = 21) had tremor characteristics similar to that of patients without aura (N = 9) and controls. Conclusion.-These results suggest that, if a link exists between migraine and ET, the latter might be the result of an "acute event" (eg, stroke) rather than a progressive alteration of tremorogenic mechanisms."

Wilson's Disease: A Great Masquerader. (Eur Neurol. 2006) "The 6 most common manifestations were dysarthria (80%), drooling (48%), tremor in limbs (44%), abnormal gait (44%), psychiatric and/or sleep symptoms (44%), and dystonia in limbs (42%). Conclusion: Neurologic WD has heterogeneous manifestations and should be considered in young patients presenting with dysarthria, drooling, any kind of movement disorders or psychiatric symptoms."

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