Gastroesophageal Reflux Disease

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Gastroesophageal Reflux Disease

General Information

NEWS:

Acid reflux common in COPD patients: study "More than half of patients with advanced COPD have gastroesophageal reflux disease (GERD), new research suggests. In GERD, stomach acid seeps into the esophagus causing burning and pain in the chest. COPD, short for chronic obstructive pulmonary disease, is a progressive lung disease caused by smoking that includes emphysema and chronic bronchitis. "

ARTICLES:

10 Tips for Heartburn Free Nights

Acid reflux may be doing more damage than you think. " … because people who have more persistent and severe cases of heartburn may carry a higher risk of developing cancer of the esophagus and larynx (voicebox). Having persistent or regularly recurring heartburn symptoms is associated with a condition called Barrett's esophagus, in which ongoing exposure to acid is thought to change the type of cells lining the esophagus."

GERD Update: The Refractory Patient “Heartburn, one of the classic symptoms of gastroesophageal reflux disease (GERD), is a very common occurrence among the general population. In the United States, approximately 44% of the population experience symptoms of GERD monthly, while 20% have symptoms on a weekly basis.1 The prevalence of GERD increases with age in those 40 or older. The increased incidence of GERD in seniors remains unclear; however, changes in the antireflux mechanism that occur with age (e.g., less consistent esophageal peristalsis, decreased salivary response to esophageal acid infusion, etc.) may be responsible.2”

Hazards of Nighttime Heartburn

JOURNAL ARTICLES:

A Retrospective, Case-Control Pilot Study of the Natural History of Pediatric Gastroesophageal Reflux. (Dig Dis Sci. 2007) "These data suggest that pediatric GER is a heterogeneous disorder and that GERD occurring after infancy may be more predictive of the presence of GERD during adulthood. Longitudinal follow-up of a larger number of children is needed to answer the question of when classic adulthood GERD begins."

Association of Extraesophageal Reflux Disease and Sinonasal Symptoms: Prevalence and Impact on Quality of Life. (Laryngoscope. 2007)

Defining the relationship between gastroesophageal reflux and cough: probabilities, possibilities and limitations. (Cough. 2007)

Determinants of gastroesophageal reflux disease in adults with a history of childhood gastroesophageal reflux disease. (Clin Gastroenterol Hepatol. 2007)

Developments in pathogenesis and diagnosis of gastroesophageal reflux disease. (Curr Opin Gastroenterol. 2007)

Does Barrett's oesophagus develop over time in patients with chronic gastro-oesophageal reflux disease? (Aliment Pharmacol Ther. 2007)

Dyspepsia in general practice: incidence, risk factors, comorbidity and mortality. (Fam Pract. 2007)

Effects of Age on the Gastroesophageal Junction, Esophageal Motility, and Reflux Disease. (Clin Gastroenterol Hepatol. 2007) "CONCLUSIONS: Age was associated with an increase in esophageal acid exposure; however, the severity of reflux symptoms reduced with age. These changes were associated with progressive decrease in abdominal LES length and esophageal motility. Increasing GERD severity in the elderly is related to degradation of the gastroesophageal junction and impaired esophageal clearance."

Erosive Esophagitis and Nonerosive Reflux Disease (NERD): Comparison of Epidemiologic, Physiologic, and Therapeutic Characteristics. (J Clin Gastroenterol. 2007) " Nonerosive reflux disease (NERD) and erosive esophagitis are the main presentations of gastroesophageal reflux disease. However, NERD is the most common presentation of gastroesophageal reflux disease in community-based patients. Patients with NERD differ in demographic characteristics from patients with erosive esophagitis, primarily in sex distribution, weight/body mass index, and prevalence of hiatal hernia."

Gastrooesophageal reflux disease (Best Practice & Research Clinical Gastroenterology 2007)

Gastroesophageal Reflux Disease (GERD): Is There More to the Story? (ChemMedChem. 2007)

Gastroesophageal reflux disease: beyond mucosal injury. (J Clin Gastroenterol. 2007)

Gastroesophageal reflux disease symptoms are more common in general practice in Japan. (World J Gastroenterol. 2007)

[Gastroesophageal reflux disease: clinical and pathophysiological features (part I)] (Clin Ter. 2007) "GERD has different clinical presentations which may be divided in three main classes: typical symptoms (heartburn and regurgitation); atypical or extraesophageal symptoms (angina-like chest pain, asthma, chronic cough and laryngitis); and complications (ulcers, strictures and Barrett's esophagus). In GERD diagnosis a key role is played by: accurate symptom evaluation, response to proton pump inhibitors and, finally, at least one in a life-time endoscopy. Moreover, barium swallow X-ray, 24-h esophageal pH monitoring and gastro-esophageal manometry can be useful to support diagnosis in some unusual cases or in cases partially or unresponsive to standard pharmacologic treatment."

Gastrooesophageal reflux disease is a progressive disease. (Dig Liver Dis. 2007)

Gastroesophageal Reflux Symptoms During and After Pregnancy: A Longitudinal Study. (Am J Gastroenterol. 2007) "CONCLUSIONS: Incidence of GERS is similar across the three trimesters of pregnancy. Accumulated weight gain during pregnancy is associated with a higher risk of GERS in the third trimester. Pregnancy might constitute a risk factor for developing GERS 1 yr postpartum."

Gastro-oesophageal reflux disease in chronic laryngitis: prevalence and response to acid-suppressive therapy. (Aliment Pharmacol Ther. 2007) "Conclusions The prevalence of gastro-oesophageal reflux disease amongst our patients with chronic laryngitis was high. The response to treatment with proton-pump inhibitors in patients with reflux disease compared to those without underlined the critical role of acid reflux in a subset of patients with chronic laryngitis."

GERD: A fresh look at a common problem in primary care. (J Fam Pract. 2007)

Helicobacter pylori and gastro-esopha-geal reflux disease: clinical considerations. (Minerva Gastroenterol Dietol. 2007)

Helicobacter pylori, Ethnicity, and the Gastroesophageal Reflux Disease Spectrum: A Study from the East. (Helicobacter. 2007)

[Influence of lifestyle in patients with gastroesophageal reflux disease.] (Med Clin (Barc). 2007) "Obesity, the decubitus, eating rapidly, tobacco, alcohol and exercise provoke symptoms of the reflux (hearthburn and acid regurgitation). The proportion of fat in the food and stress aren't factors associated with reflux. Some works point at the chocolate, at the acid juices, at the carbonated beverages and at the onions as factors that unleash symptoms of reflux."

Is Reflux Cough Due to Gastroesophageal Reflux Disease or Laryngopharyngeal Reflux? (Lung. 2007)

Laryngeal disorders in patients with gastroesophageal reflux disease. (Minerva Gastroenterol Dietol. 2007) "Gastroesophageal reflux disease (GERD) is a common medical condition affecting approximately 35-40% of the adult population in the western world. Chronic laryngeal signs and symptoms associated with GERD are often referred to as reflux laryngitis or laryngopharyngeal reflux (LPR). It is estimated that up to 15% of all visits to the otolaryngology offices are because of manifestations of LPR. … The most common presenting symptoms of LPR include hoarseness, sore throat, throat clearing, and chronic cough. The diagnosis of LPR is usually made on the basis of presenting symptoms and associated laryngeal signs including laryngeal edema and erythema."

Otitis media in adults as a symptom of gastroesophageal reflux. (Otolaryngol Head Neck Surg. 2007) "CONCLUSION: The presence of PG in MEEs supports the existence of GER; treatment for GER should be considered in patients with ear complaints, especially in those who have GER-related symptoms."

Overlap of gastro-oesophageal reflux disease and irritable bowel syndrome: prevalence and risk factors in the general population. (Aliment Pharmacol Ther. 2007)

Prediction of gastroesophageal reflux in otitis media with effusion in adults. (Acta Otolaryngol. 2007)

Prevalence of gastroesophageal reflux disease in patients with laryngeal and voice disorders. (Saudi Med J. 2007) "CONCLUSION: Laryngeal and voice disorders was mostly due to GERD in 80% of patients, which was mainly GERD with hiatus hernia."

Prevalence of Upper Gastrointestinal Tract Findings in Patients With Noncardiac Chest Pain Versus Those With Gastroesophageal Reflux Disease (GERD)-Related Symptoms: Results from a National Endoscopic Database. (Am J Gastroenterol. 2007)

Relation Between Gastroesophageal Reflux Symptoms and Socioeconomic Factors: A Population-Based Study (the HUNT Study). (Clin Gastroenterol Hepatol. 2007)

Review article: the pathophysiology of gastro-oesophageal reflux disease. (Aliment Pharmacol Ther. 2007)

Severe symptoms of gastro-oesophageal reflux disease are associated with cardiovascular disease and other gastrointestinal symptoms, but not diabetes: a population-based study. (Aliment Pharmacol Ther. 2007) "Conclusions: This population-based study indicates that myocardial infarction, angina pectoris, stroke and symptoms of nausea, diarrhoea and constipation are associated with GORD."

Sleep Dysfunction in Patients With GERD: Erosive Versus Nonerosive Reflux Disease. (Am J Med Sci. 2007) "CONCLUSIONS:: Despite no difference in sleep quality between erosive esophagitis and NERD, NERD can have a significant impact on sleep comparable to erosive esophagitis. It is suggested that NERD should be treated aggressively and at least similarly to erosive esophagitis."

[Two thirds of patients with gastroesophageal reflux have nocturnal symptoms.] (Presse Med. 2007) "CONCLUSION: Approximately 2/3 of GERD patients have nocturnal symptoms that appear to have a significant negative impact on sleep and well-being. These results show the need to evaluate specific therapeutic approaches to reduce sleep disturbances in these patients."

Unspecified abdominal pain in primary care: the role of gastrointestinal morbidity. (Int J Clin Pract. 2007)

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