Gastroesophageal Reflux Disease
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Notes
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Gastroesophageal Reflux Disease
Daily Treatment Report
Cognitive Therapy-CBT-Psychotherapy
Device Therapy
Drug Side-Effects and Interactions
[Side effects of proton pump inhibitors (PPIs)] (Rev Med Suisse. 2007)
Drugs
Beating Back GERD with PPIs "Nearly 15 million Americans suffer daily from symptoms related to gastroesophageal reflux disease (GERD), and nearly 38 million people experience symptoms at least weekly.1-3 A sedentary lifestyle contributes to the prevalence of the disease. Patients with GERD frequently are overweight, eat large high-fat meals, and drink caffeinated beverages—all of which increase the dilation of the lower esophageal sphincter and the subsequent reflux of acid into the lower esophagus (LE).4 … All PPIs generally are well-tolerated, with the most frequently reported adverse events being headache, diarrhea, and abdominal pain.15 Atrophic gastritis has been noted occasionally in gastric corpus biopsies from patients treated over a long term with omeprazole. Reaction to the sodium bicarbonate contained in IR-OME, including metabolic alkalosis, is possible in some patients.9"
Proton Pump Inhibitors Improve Acid-Related Dyspepsia in Gastroesophageal Reflux Disease Patients. (Dig Dis Sci. 2007) "We conclude that GERD patients suffer not only from reflux symptoms, but also from acid-related dyspepsia, and proton pump inhibitors improve both types of symptoms."
Long-term treatment of patients with gastro-oesophageal reflux disease in routine care - results from the ProGERD study. (Aliment Pharmacol Ther. 2007) "Three-quarters of the GERD population in our study reported long-term treatment with a PPI. Continuous PPI intake was the predominant treatment pattern, and the proportion of patients taking a PPI on a continuous basis remained constant over time."
Consumer Reports Best Buy Drugs: Treating Heartburn, Acid Reflux, and Ulcers – The PPIs
Exercise
General Information
How to manage refractory GERD. (Nat Clin Pract Gastroenterol Hepatol. 2007)
Systematic review: maintenance treatment of gastro-oesophageal reflux disease with proton pump inhibitors taken 'on-demand' (Aliment Pharmacol Ther. 2007) " Conclusions On the basis of the analysis of 17 studies, we can conclude that on-demand therapy with currently available PPI appears to be effective in the long-term management of patients with NERD or mild and uninvestigated forms of GERD, but not in patients with (severe) erosive oesophagitis."
Relationship between symptoms, subjective well-being and medication use in gastro-oesophageal reflux disease. (Int J Clin Pract. 2007) "Conclusions: These findings attest to the severity and impact of GERD symptoms, highlighting the need to improve the management of GERD in routine practice. Many symptomatic and long-term sufferers, for example, may benefit from taking steps towards a healthier lifestyle (e.g. weight reduction) in addition to optimisation of acid-suppressive therapy."
Effect of antireflux treatment on asthma exacerbations in nonatopic children. (J Pediatr Gastroenterol Nutr. 2007) "CONCLUSIONS: Fundoplication or continued treatment with esomeprazole and metoclopramide is associated with significantly fewer exacerbations of asthma symptoms in children with moderate-persistent asthma and concomitant GERD in comparison with treatment with ranitidine."
[Management of gastro-esophageal reflux disease in primary care. Results from an observational study of 2 474 patients (AO).] (Gastroenterol Clin Biol. 2007) "CONCLUSIONS: GERD managed in primary care is severe, leading to expensive, but effective diagnostic investigations and treatments. Agreement with recommendations for endoscopy is poor."
Prevalence of Upper Gastrointestinal Tract Findings in Patients With Noncardiac Chest Pain Versus Those With Gastroesophageal Reflux Disease (GERD)-Related Symptoms: Results from a National Endoscopic Database. (Am J Gastroenterol. 2007)
Guidelines
Immunotherapy
Internet Sites
Treatment Information
Drug-Food-Supplement Information
DrugDigest (drug interactions)
FDA - Drug Interactions: What You Should Know
NIH - Botanical Dietary Supplements: Background Information
NIH - Drug, Supplements, and Herbal Information
NIH - Herbal Supplements: Consider Safety, Too
NIH - Vitamin and Mineral Supplement Fact Sheets
Nutrition
Other
Other Treatments
Experimental
Radiotherapy
Supplements-Vitamins-CAM
Surgery
Laparoscopic Nissen Fundoplication: Clinical Outcomes at 10 Years. (J Am Coll Surg. 2007)
The safety of the same-day discharge for selected patients after laparoscopic fundoplication: a prospective cohort study. (Am J Surg. 2007)
Comparison of long-term outcome of laparoscopic and conventional nissen fundoplication: a prospective randomized study with an 11-year follow-up. (Ann Surg. 2007)
[Evaluation of the efficacy of surgical treatment of gastroesophageal reflux disease] (Pol Merkur Lekarski. 2007)
Endotherapy and surgery for GERD. (J Clin Gastroenterol. 2007)
The Use of pH Monitoring and Esophageal Manometry in the Evaluation of Results of Surgical Therapy for Gastroesophageal Reflux Disease. (Eur J Pediatr Surg. 2007)
Influence of age on outcome of total laparoscopic fundoplication for gastroesophageal reflux disease. (World J Gastroenterol. 2007) "CONCLUSION: Laparoscopic antireflux surgery is a safe and effective treatment for GERD even in elderly patients, warranting low morbidity and mortality rates and a significant improvement of symptoms comparable to younger patients."
Transplantation
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