Aging - Anti-Aging

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Aging - Dehydration

Strategies for ensuring good hydration in the elderly. (Nutr Rev. 2005)

"Dehydration is a frequent etiology of morbidity and mortality in elderly people. It causes the hospitalization of many patients and its outcome may be fatal. Indeed, dehydration is often linked to infection, and if it is overlooked, mortality may be over 50%. Older individuals have been shown to have a higher risk of developing dehydration than younger adults. Modifications in water metabolism with aging and fluid imbalance in the frail elderly are the main factors to consider in the prevention of dehydration. Particularly, a decrease in the fat free mass, which is hydrated and contains 73% water, is observed in the elderly due to losses in muscular mass, total body water, and bone mass. Since water intake is mainly stimulated by thirst, and since the thirst sensation decreases with aging, risk factors for dehydration are those that lead to a loss of autonomy or a loss of cognitive function that limit the access to beverages."

Highlighted Article

A typology of oral hydration problems exhibited by frail nursing home residents. (J Gerontol Nurs. 2006)

"Dehydration remains a substantial problem for nursing home residents, often with poor health outcomes. … Dehydration events occurred in 31% (11 of 35) of residents during the 6-month period."

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Aging and Anti-Aging

Imaging

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Aging, grey matter, and blood flow in the anterior cingulate cortex. (Neuroimage. 2007)

Brain atrophy and white matter hyperintensity change in older adults and relationship to blood pressure : Brain atrophy, WMH change and blood pressure. (J Neurol. 2007)

Brain tissue volumes in the general elderly population The Rotterdam Scan Study. (Neurobiol Aging. 2007) "Persons with larger load of small vessel disease had smaller brain volume, especially normal WM volume. Diastolic blood pressure, diabetes mellitus and current smoking were also related to smaller brain volume. In the elderly, higher age, small vessel disease and cardiovascular risk factors are associated with smaller brain volume, especially WM volume."

Functional MRI studies of associative encoding in normal aging, mild cognitive impairment, and Alzheimer's disease. (Ann N Y Acad Sci. 2007)

Longitudinal MRI and cognitive change in healthy elderly. (Neuropsychology. 2007) "Results suggest that in normal aging, cognitive functioning declines as cortical gray matter and hippocampus decrease, and WMSH increases. The association between WMSH and EXEC further highlights the cognitive sequealae associated with cerebrovascular disease in normal elderly."

Morphological substrates of cognitive decline in nonagenarians and centenarians: A new paradigm? (J Neurol Sci. 2007) "Our recent stereological observations of hippocampal microvasculature in oldest-old cases challenge the traditional lesional model by revealing that mean capillary diameters is an important structural determinant of cognition in this age group."

Structural and functional imaging correlates for age-related changes in the brain. (Semin Nucl Med. 2007)

The length of hippocampal cholinergic fibers is reduced in the aging brain (Neurobiology of Aging 2007)

Where the brain grows old: Decline in anterior cingulate and medial prefrontal function with normal aging. (Neuroimage. 2007)

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