Aging - Anti-Aging
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REVIEW our Selected Aging Articles in 2006. Stay informed and updated!
Also review Related Articles: Alzheimer's Disease, Fitness and Exercise.
Aging - Dehydration
Strategies for ensuring good hydration in the elderly. (Nutr Rev. 2005)
"Dehydration is a frequent etiology of morbidity and mortality in elderly people. It causes the hospitalization of many patients and its outcome may be fatal. Indeed, dehydration is often linked to infection, and if it is overlooked, mortality may be over 50%. Older individuals have been shown to have a higher risk of developing dehydration than younger adults. Modifications in water metabolism with aging and fluid imbalance in the frail elderly are the main factors to consider in the prevention of dehydration. Particularly, a decrease in the fat free mass, which is hydrated and contains 73% water, is observed in the elderly due to losses in muscular mass, total body water, and bone mass. Since water intake is mainly stimulated by thirst, and since the thirst sensation decreases with aging, risk factors for dehydration are those that lead to a loss of autonomy or a loss of cognitive function that limit the access to beverages."
Highlighted Article
A typology of oral hydration problems exhibited by frail nursing home residents. (J Gerontol Nurs. 2006)
"Dehydration remains a substantial problem for nursing home residents, often with poor health outcomes. … Dehydration events occurred in 31% (11 of 35) of residents during the 6-month period."
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Notes
The Guidelines section will contain the 2006 and certain 2005 updated published guidelines. To view Guidelines from previous years, view year 2005 InfoMedlinks (Articles section) or our Monthly Online Newsletter (under the Guidelines section).
Aging - Anti-Aging
Daily Treatment Report
Cognitive Therapy-CBT-Psychotherapy
Device Therapy
Drug Side-Effects and Interactions
Intramuscular Testosterone Treatment in Elderly Men: Evidence of Memory Decline and Altered Brain Function. (J Clin Endocrinol Metab. 2007) "Conclusions. Decreased verbal memory and altered relative activity in medial temporal and prefrontal regions suggests possible detrimental effects of supraphysiological testosterone supplementation in elderly men. The results do not rule out potential benefits with other regimens, cognitive tests, or populations."
Testosterone and cardiovascular risk in men: a systematic review and meta-analysis of randomized placebo-controlled trials. (Mayo Clin Proc. 2007) "CONCLUSION: Currently available evidence weakly supports the inference that testosterone use in men is not associated with important cardiovascular effects. Patients and clinicians need large randomized trials of men at risk for cardiovascular disease to better inform the safety of long-term testosterone use."
Testosterone Use for Aging Questioned "A growing number of middle-aged and elderly men are using testosterone creams, gels, and patches in an effort to feel young again, but there is little evidence the treatments are either effective or safe. That is the conclusion of investigators from the Mayo Clinic who conducted two research analyses of testosterone therap … there are suggestions that testosterone treatment may actually increase a man's risk of heart disease as well as prostate cancerprostate cancer and benign prostate growth."
Drugs
Hormone therapy and postural balance in elderly women. (Menopause. 2007) "CONCLUSIONS:: In elderly women low endogenous serum E2 levels were associated with greater impairment of postural balance function during the study, whereas HT, as compared with placebo, improved postural balance in women with low serum E2 levels."
Effects of Two Years of Testosterone Replacement on Insulin Secretion, Insulin Action, Glucose Effectiveness, Hepatic Insulin Clearance and Postprandial Glucose Turnover in Elderly Men. (Diabetes Care. 2007) "Conclusions: We conclude that two years of treatment of elderly men with testosterone does not improve carbohydrate tolerance nor does it alter insulin secretion, insulin action, glucose effectiveness, hepatic insulin clearance or the pattern of postprandial glucose metabolism. Thus testosterone deficiency is unlikely to be the cause of the age associated deterioration in glucose tolerance commonly observed in elderly men."
Canadian Society for the Study of the Aging Male: Response to Health Canada's Position Paper on Testosterone Treatment. (J Sex Med. 2007) "Conclusion. CSSAM acted as an advocate for hypogonadal men who may benefit from treatment with testosterone. Short-term studies and 60 years of experience with testosterone therapy attest to its efficacy. Long-term studies are desirable, but it may take many years before results could be forthcoming. There is no evidence to suggest that testosterone treatment increases the risk of prostate cancer or cardiovascular disease. Current evidence suggests, in fact, that testosterone treatment may be cardioprotective. It is important to bring this information to the attention of governments and insuring agencies through the collaboration of groups devoted to the diagnosis and treatment of hypogonadal men."
Testosterone use in men with sexual dysfunction: a systematic review and meta-analysis of randomized placebo-controlled trials. (Mayo Clin Proc. 2007) "CONCLUSION: Testosterone use in men is associated with small improvements in satisfaction with erectile function and moderate improvements in libido. Unexplained inconsistent results across trials, wide CIs, and possible reporting bias weaken these inferences."
Exercise
General Information
Systematic Review: The Safety and Efficacy of Growth Hormone in the Healthy Elderly (Ann Intern Med 2007) "Conclusions: The literature published on randomized, controlled trials evaluating GH therapy in the healthy elderly is limited but suggests that it is associated with small changes in body composition and increased rates of adverse events. On the basis of this evidence, GH cannot be recommended as an antiaging therapy."
Guidelines
Immunotherapy
Internet Sites
Treatment Information
Drug-Food-Supplement Information
DrugDigest (drug interactions)
FDA - Drug Interactions: What You Should Know
NIH - Botanical Dietary Supplements: Background Information
NIH - Drug, Supplements, and Herbal Information
NIH - Herbal Supplements: Consider Safety, Too
NIH - Vitamin and Mineral Supplement Fact Sheets
Nutrition
Other
Other Treatments
Experimental
Supplements-Vitamins-CAM
Acetyl l-carnitine (ALC) treatment in elderly patients with fatigue (Archives of Gerontology and Geriatrics 2007) "Our data show that administering ALC may reduce both physical and mental fatigue in elderly and improves both the cognitive status and physical functions."
Chronic melatonin treatment reduces the age-dependent inflammatory process in senescence-accelerated mice. (J Pineal Res. 2007) "The results of this study suggest the existence of an inflammatory process during aging and further support that melatonin behaves as an essential molecule against aging, for its anti-inflammatory properties together with its antioxidative role reported elsewhere."
Surgery
Transplantation
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