Osteoarthritis

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Osteoarthritis

General Information

NEWS:

Exercise Won't Up Knee Arthritis Risk " Moderate exercise doesn't increase the risk of developing arthritis in the knees of older adults, even if they are overweight, according to a new study that evaluated more than 1,200 people."

Knee Pain May Signal Lung Cancer "Heavy smokers with knee arthritis may be experiencing an early sign of a difficult-to-treat lung cancer, research shows. … About 85 percent of all lung cancers are non-small cell lung cancer, according to the American Cancer Society. Unless it is caught early, non-small cell lung cancer is difficult to treat. It spreads to the bones in one in five cases and is well advanced by the time it is diagnosed in half of all cases."

Smoking May Play Role in Knee Osteoarthritis "Smoking may increase the risk for cartilage loss and more severe pain in men with osteoarthritis of the knee, according to a new study."

ARTICLES:

JOURNAL ARTICLES:

Calcification of human articular knee cartilage is primarily an effect of aging rather than osteoarthritis. (Osteoarthritis Cartilage. 2007) "CONCLUSION: These observations indicate that age rather than OA is the predominant factor driving progressive pathologic calcification in articular cartilage."

Degenerative meniscus tears and mobility impairment in women with knee osteoarthritis. (Osteoarthritis Cartilage. 2007) "CONCLUSION: Meniscus tears, diagnosed by MRI, are very common in older women with knee OA, particularly in the medial compartment. These incidentally discovered tears are associated with clinically relevant impairments of balance and walking endurance relative to subjects without meniscus tears. The explanation for this association requires further study."

Isolated knee monoarthritis heralding resectable non small-cell lung cancer. A paraneoplastic syndrome not previously described. (Ann Rheum Dis. 2007) "CONCLUSION: Knee monoarthritis may represent in some cases a paraneoplastic syndrome heralding NSCLC in an early stage."

Isolated patellofemoral osteoarthritis. (Knee. 2007)

Knee alignment does not predict incident osteoarthritis: The Framingham osteoarthritis study. (Arthritis Rheum. 2007) "CONCLUSION: We found that baseline knee alignment is not associated with either incident radiographic TF OA or medial TF OA. These results suggest that malalignment is not a risk factor for OA, but rather is a marker of disease severity and/or its progression."

Osteoarthritis. (J Cell Physiol. 2007)

Osteoarthritis: what we have been missing in the patellofemoral joint. (Exerc Sport Sci Rev. 2008)

[Pathogenesis of hip osteoarthritis] (MMW Fortschr Med. 2007)

Prevalence of knee symptoms and radiographic and symptomatic knee osteoarthritis in african americans and Caucasians: the johnston county osteoarthritis project. (J Rheumatol. 2007) " RESULTS: Knee symptoms were present in 43%, 28% had radiographic knee OA, 16% had symptomatic knee OA, and 8% had severe radiographic knee OA. Prevalence was higher in older individuals and women. African Americans had slightly higher prevalence of knee symptoms, radiographic knee OA, and symptomatic knee OA, but significantly higher prevalence of severe radiographic knee OA compared to Caucasians. CONCLUSION: Policy should be directed to increasing education of the public and the medical community about the high prevalence of these conditions, especially in these subgroups, to decrease their impact and ultimately prevent them."

Prognostic factors of progression of osteoarthritis of the knee: A systematic review of observational studies. (Arthritis Rheum. 2007) "CONCLUSION: Generalized OA and level of hyaluronic acid seem to be associated with the radiologic progression of knee OA. Knee pain, radiologic severity at baseline, sex, quadriceps strength, knee injury, and regular sport activities seem not to be related. For other factors, the evidence was limited or conflicting."

Risk factors and prognostic factors of hip and knee osteoarthritis. (Nat Clin Pract Rheumatol. 2007)

Status of lipid peroxidation, glutathione, ascorbic acid, vitamin E and antioxidant enzymes in patients with osteoarthritis. (Indian J Med Sci. 2007) " CONCLUSIONS: The results of our study suggest higher oxygen-free radical production, evidenced by increased MDA and decreased GSH, ascorbic acid, vitamin E and catalase activity, support to the oxidative stress in osteoarthritis. The increased activities of antioxidant enzymes may be a compensatory regulation in response to increased oxidative stress."

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