Cervical Cancer

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Cervical Cancer

NIH - Medical Encyclopedia Cervical Cancer

"Cervical cancer is cancer that starts in the cervix, the lower part of the uterus (womb) that opens at the top of the vagina. … Worldwide, cervical cancer is the third most common type of cancer in women. … Cervical cancers start in the cells on the surface of the cervix. There are two types of cells on the cervix's surface: squamous and columnar. The majority of cervical cancers are from squamous cells. The development of cervical cancer is very slow. It starts as a pre-cancerous condition called dysplasia. This pre-cancerous condition can be detected by a Pap smear and is 100% treatable. That is why it is so important for women to get regular Pap smears … Undetected, pre-cancerous changes can develop into cervical cancer and spread to the bladder, intestines, lungs, and liver. … Almost all cervical cancers are caused by HPV (human papillomavirus). … Other risk factors for cervical cancer include: • Having sex at an early age • Multiple sexual partners • Sexual partners who have multiple partners or who participate in high-risk sexual activities • Women whose mothers took the drug DES (diethylstilbestrol) during pregnancy in the early 1970s to prevent miscarriage • Long-term use of birth control pills (more than 5 years) • Weakened immune system • Infections with genital herpes or chronic chlamydia infections • Poor economic status (may not be able to afford regular Pap smears)."

Highlighted Article

Prevalence of HPV Infection Among Females in the United States (JAMA. 2007)

"Results The overall HPV prevalence was 26.8% … among US females aged 14 to 59 years … HPV prevalence was 24.5% (19.6%-30.5%) among females aged 14 to 19 years, 44.8% (36.3%-55.3%) among women aged 20 to 24 years, 27.4% (21.9%-34.2%) among women aged 25 to 29 years, 27.5% (20.8%-36.4%) among women aged 30 to 39 years, 25.2% (19.7%-32.2%) among women aged 40 to 49 years, and 19.6% (14.3%-26.8%) among women aged 50 to 59 years. There was a statistically significant trend for increasing HPV prevalence with each year of age from 14 to 24 years … followed by a gradual decline in prevalence through 59 years … HPV is common among females in the United States. Our data indicate that the burden of prevalent HPV infection among females was greater than previous estimates and was highest among those aged 20 to 24 years."

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Cervical Cancer

Daily Treatment Report

Cognitive Therapy-CBT-Psychotherapy

Device Therapy

Drug Side-Effects and Interactions

Drugs

Chemotherapy for recurrent cervical cancer. (Gynecol Oncol. 2007)

Chemotherapy for recurrent, metastatic, or persistent cervical cancer: a systematic review. (Int J Gynecol Cancer. 2007)

Exercise

General Information

Chemo-conization in early cervical cancer. (Gynecol Oncol. 2007)

Conservative approaches in early stages of cervical cancer. (Gynecol Oncol. 2007)

Urological complications after radical hysterectomy: incidence rates and predisposing factors. (Vojnosanit Pregl. 2007) "CONCLUSION: The stage of the disease seem to be the most significant factor in the development of intraoperative ureter and bladder injuries. The stage of the disease, intraoperative bladder injury, diabetes mellitus and postoperative infection of surgical site are the most significant factors in the development of postoperative fistuls."

Management of Metastatic Cervical Cancer: Review of the Literature (Journal of Clinical Oncology 2007)

Radiotherapy in the adjuvant setting of cervical carcinoma: treatment, results, and prognostic factors. (Int J Gynecol Cancer. 2007) "Our results indicate that level and number of metastatic LNs are the most important prognostic factors determining the survival rates, and patients with upper lymphatic involvement or more than three metastatic LNs seem to need more effective treatment approaches."

Cancer free survival after CIN treatment: Comparisons of treatment methods and histology. (Gynecol Oncol. 2007)

Lymph Node Involvement in Locally Advanced Cervical Cancer Patients Administered Preoperative Chemoradiation versus Chemotherapy. (Ann Surg Oncol. 2007)

Guidelines

Immunotherapy

Internet Sites

Treatment Information

DrugBank (drug structure)

FDA - MedWatch (Drug Alerts)

NCI - Dictionary of Cancer Terms

NCI - Drug Dictionary

NCI - Overview of Nutrition in Cancer Care

Drug-Food-Supplement Information

Drug Information Online

Drug Interaction Checker

DrugDigest (drug interactions)

FDA - Drug Interactions: What You Should Know

NIH - Botanical Dietary Supplements: Background Information

NIH - Drug, Supplements, and Herbal Information

NIH - Herbal Supplements: Consider Safety, Too

NIH - Medicines

NIH - Vitamin and Mineral Supplement Fact Sheets

Nutrition

Other

Radiation-Chemotherapy

Other Treatments

Experimental

Radiotherapy

Concurrent carboplatin and paclitaxel with pelvic radiation therapy in the primary treatment of cervical cancer. (Am J Obstet Gynecol. 2007)

Radiation therapy for cervical cancer in the elderly. (Gynecol Oncol. 2007) "CONCLUSIONS.: RT was well tolerated in elderly patients, and age was not a significant prognostic factor. In the management of cervical cancer, advanced age is not a contraindication to radical RT."

Radiotherapy in the adjuvant setting of cervical carcinoma: treatment, results, and prognostic factors (International Journal of Gynecological Cancer 2007) "Our results indicate that level and number of metastatic LNs are the most important prognostic factors determining the survival rates, and patients with upper lymphatic involvement or more than three metastatic LNs seem to need more effective treatment approaches. "

Supplements-Vitamins-CAM

Surgery

Role of human papillomavirus genotype in prognosis of early-stage cervical cancer undergoing primary surgery. (J Clin Oncol. 2007)

Vaginal blood flow after radical hysterectomy with and without nerve sparing. A preliminary report. (Int J Gynecol Cancer. 2007)

Transplantation

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