Colorectal Cancer

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Colorectal Cancer

General Information

NEWS:

Dietary fiber doesn't lower colorectal cancer risk "After analyzing fiber from different food sources, the team found that only fiber from grains was associated with a lower risk of colorectal cancer. The risk of colorectal cancer was lowered by 14 percent among the subjects with the highest amounts of grain in their diet compared with those with the lowest amounts. The association with whole grains was stronger for rectal than for colon cancer. Nevertheless, concluded Schatzkin, the study findings support the recommendation of eating more unprocessed cereals or pulses and avoiding refined starchy foods to lower the risk of colorectal cancer. "

Study Links Coronary Disease, Colon Cancer "People newly diagnosed with coronary artery disease had nearly double the normal incidence of colorectal tumors and cancers, a study by Hong Kong researchers found. Both the tumors and the heart disease 'probably develop through the mechanism of chronic inflammation,' said the report by researchers at the University of Hong Kong that's published in the Sept. 26 issue of the Journal of the American Medical Association. But U.S. experts said the risk factors for both diseases are remarkably similar. 'A high-fat diet, a high-protein diet, a sedentary lifestyle,' said Dr. Randall W. Burt, director of prevention and outreach at the University of Utah Huntsman Cancer Institute. 'We know that the same factors that are important for coronary artery disease are important for colon cancer risk. What they [the Hong Kong researchers] have done is put the two together.' "

ARTICLES:

NIH - Colorectal Cancer Fact Sheet

Outliving colorectal cancer.

JOURNAL ARTICLES:

Colorectal cancer. (Mayo Clin Proc. 2007)

Colorectal cancer in the young patient. (Am Surg. 2007) " The study provides more evidence to support the fact that young patients with colorectal cancer seem to present with more advanced disease. Despite this, the overall 5-year relative survival rate is comparable if not better than other studies, supporting recent evidence that the prognosis in this group of patients is no worse than for colorectal cancer in the population as a whole."

Colorectal neoplasm in asymptomatic Asians: a prospective multinational multicenter colonoscopy survey. (Gastrointest Endosc. 2007)

Cryptosporidiosis in patients with colorectal cancer. (J Parasitol. 2007)

Detection of tissue abnormalities in normal mucosa surrounding colorectal cancer using an endocytoscopy system. (Endoscopy. 2007)

Diet and colorectal cancer: Review of the evidence. (Can Fam Physician. 2007)

Dietary Fiber Intake in Two European Diets with High (Copenhagen, Denmark) and Low (Murcia, Spain) Colorectal Cancer Incidence. (J Agric Food Chem. 2007)

Emergency Room Presentation of Colorectal Cancer: A Consecutive Cohort Study. (Ann Surg Oncol. 2007) "BACKGROUND: Emergency room presentation (ERP) in colorectal cancer (CRC) is associated with worse cancer-related outcomes. The goal of this study was to determine the frequency of ERP and identify factors associated with ERP of CRC. … RESULTS: Of the 455 patients in the study 108 (24%) had ERP. Presentation of those with ERP was obstruction in 46 (43%), bleeding/anemia in 35 (32%), pain in 25 (23%), and other (2%). The ERP cohort was older (mean age 70.8 vs. 67.0 years, P = 0.005). ERP was more common amongst females (29.7 vs. 18.2%, P = 0.004) and obesity appears to be associated with increased rates of ERP. ERP of CRC was associated with more advanced TNM stage."

Influence of diet and lifestyle in colorectal cancer. (Rev Esp Enferm Dig. 2007) "Conclusions: there is a significant relationship between colorectal cancer and familial cancer, physical activity, and the ingestion of alcohol, water, pasta, rice, and eggs."

Long-term outcome and prognostic factors in patients with cervical carcinoma: a retrospective study. (Int J Gynecol Cancer. 2007)

[Nutrition and colorectal cancer] (Med Monatsschr Pharm. 2007)

Oral Contraceptives, Reproductive Factors, and Risk of Colorectal Cancer among Women in a Prospective Cohort Study. (Am J Epidemiol. 2007) "No significant association was observed between reproductive factors and colorectal cancer risk. These findings provide some support for a potential role of OCs in reducing risk of colorectal cancer."

Pathology of the hereditary colorectal carcinoma. (Fam Cancer. 2007)

Physical activity before and after diagnosis of colorectal cancer : disease risk, clinical outcomes, response pathways and biomarkers. (Sports Med. 2007)

Plasma vitamin B12 concentrations and the risk of colorectal cancer: A nested case-referent study. (Int J Cancer. 2007) “In conclusion, these results suggest that increasing levels of plasma vitamin B12, alone or together with other factors involved in one-carbon metabolism, may reduce the risk of rectal cancer, whereas for colon cancer, the association appears to be less clear.”

Predictors of distant metastasis and mortality in patients with stage II colorectal cancer. (Am Surg. 2007)

Review article: nutrition, obesity and colorectal cancer. (Aliment Pharmacol Ther. 2007) "Dietary factors may account for 75% of sporadic colorectal cancer in the west, but the mechanisms remain obscure. … There is evidence for adverse effects of overweight and obesity and protective effects of high physical activity against colon, but not for rectal cancer. These effects may reflect metabolic stress and chronic low-grade inflammation. There are also modest adverse effects of red and processed meat. There is evidence for protective effects of dietary fibre, but for fruits and vegetables the evidence remains weak and inconclusive. There is some evidence for protective effects of n-3 polyunsaturated fatty acids from fish, some micronutrients and possibly phytochemicals. The effects of many dietary constituents may depend upon genetic polymorphisms affecting a variety of genes."

Surgeon and hospital characteristics as predictors of major adverse outcomes following colon cancer surgery: understanding the volume-outcome relationship. (Arch Surg. 2007) "CONCLUSIONS: Very high surgeon volume is associated with a reduction in surgical complications. However, the association between increasing hospital volume and postoperative mortality appears to derive mainly from a full spectrum of clinical services that may facilitate the prompt recognition and treatment of complications."

The management of small polyps found by virtual colonoscopy: results of a decision analysis. (Clin Gastroenterol Hepatol. 2007) " Conclusions: Managing smaller polyps detected on a screening CTC with another CTC examination 3 years later likely will result in more deaths and cancers than immediate colonoscopy and polypectomy."

The patient with multiple intestinal polyps. (Best Pract Res Clin Gastroenterol. 2007)

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