Colorectal Cancer

• Diagnosis, Imaging, Screening
• General Information
• Guidelines
• Internet Sites
• Risk Factors
• Risk Reduction
• Treatment - Daily Report

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Colorectal Cancer

Daily Treatment Report

Cognitive Therapy-CBT-Psychotherapy

Device Therapy

Drug Side-Effects and Interactions

[Reduction of oxaliplatin-related neurotoxicity by calcium and magnesium infusions.] (Gan To Kagaku Ryoho. 2007)

Oral glutamine is effective for preventing oxaliplatin-induced neuropathy in colorectal cancer patients. (Oncologist. 2007)

Drugs

Third-line therapy for metastatic colorectal cancer. (Cancer Chemother Pharmacol. 2007)

Reintroduction of oxaliplatin is associated with improved survival in advanced colorectal cancer. (J Clin Oncol. 2007)

Targeted therapies in small-cell lung cancer. (Expert Opin Ther Targets. 2007)

Stage IIIA and IIIB Non-small Cell Lung Cancer: Results of Chemotherapy Combined With Radiation Therapy and Analysis of Prognostic Factors. (Arch Bronconeumol. 2007)

Optimizing chemotherapy for patients with advanced non-small cell lung cancer. (J Thorac Oncol. 2007)

Current treatment paradigms for locally advanced non-small cell lung cancer. (J Thorac Oncol. 2007)

Update on the Use of Targeted Therapies in Treating Metastatic Colorectal Cancer

Adjuvant therapy of colon cancer: current status and future directions. (Cancer J. 2007)

Adjuvant treatment of colorectal cancer. (CA Cancer J Clin. 2007)

Chemotherapy for colorectal cancer in the metastatic and adjuvant setting: past, present and future. (Expert Rev Anticancer Ther. 2007)

Oxaliplatin in the treatment of colorectal cancer. (Expert Opin Drug Metab Toxicol. 2007)

First-line treatment strategies for elderly patients with metastatic colorectal cancer. (Drugs Aging. 2007) "Treatment decisions should not be made on the basis of age. Rather, they should be based on functional status, the presence of co-morbidities, and consideration of drug-specific toxicities that can be aggravated in older individuals because of decreased functional reserve.Although the elderly have been under-represented in clinical trials, studies also support the effectiveness of combination chemotherapy in elderly patients with advanced colorectal cancer.This article reviews current optimal first-line treatment strategies for elderly patients with metastatic colorectal cancer."

[Chemotherapy for elderly patients with colorectal cancer.] (Gan To Kagaku Ryoho. 2007)

Exercise

General Information

Management of colorectal cancer in elderly patients over 80 years old. (Nippon Ronen Igakkai Zasshi. 2007)

Aspirin and Folic Acid for the Prevention of Recurrent Colorectal Adenomas. (Gastroenterology. 2007) "CONCLUSIONS: Aspirin (300 mg/day) but not folate (0.5 mg/day) use was found to reduce the risk of colorectal adenoma recurrence, with evidence that aspirin could have a significant role in preventing the development of advanced lesions."

Clinical and Pathologic Evaluation of Patients with Recurrence of Colorectal Cancer Five or More Years After Curative Resection. (Dis Colon Rectum. 2007) "CONCLUSIONS: Late recurrent colorectal cancer has some characteristics compared with early or intermediate recurrence. Although recurrence at more than five years postoperatively is not common, its possibility should be considered whenever performing follow-up, and surveillance for lung metastasis is recommended after more than five years of surgery."

[Medical therapy of progressive colorectal cancer] (Schweiz Rundsch Med Prax. 2007)

Lymph Node Evaluation and Survival After Curative Resection of Colon Cancer: Systematic Review (JNCI Journal of the National Cancer Institute 2007) "Conclusions: The number of lymph nodes evaluated after surgical resection was positively associated with survival of patients with stage II and stage III colon cancer. These results support consideration of the number of lymph nodes evaluated as a measure of the quality of colon cancer care."

Outcome of Follow-up Colon Examination Among a Population-Based Cohort of Colorectal Cancer Patients. (Clin Gastroenterol Hepatol. 2007) "CONCLUSIONS: After colorectal cancer resection, patients have a high risk of interval cancers, some of which represent missed lesions at initial diagnosis. Therefore, surveillance colonoscopy within 1 year of initial diagnosis is warranted. After adjusting for key variables, endoscopic surveillance is associated with improved survival."

Follow-up strategies for patients treated for non-metastatic colorectal cancer. (ochrane Database Syst Rev. 2007) " AUTHORS' CONCLUSIONS: The results of our review suggest that there is an overall survival benefit for intensifying the follow up of patients after curative surgery for colorectal cancer. Because of the wide variation in the follow-up programmes used in the included studies it is not possible to infer from the data the best combination and frequency of clinic (or family practice) visits, blood tests, endoscopic procedures and radiological investigations to maximise the outcomes for these patients. Nor is it possible to estimate the potential harms or costs of intensifying follow up for these patients in order to adopt a cost-effective approach in this clinical area."

Comparative Analysis of Predictive Biomarkers for Therapeutical Strategies in Colorectal Cancer. (Ann Surg Oncol. 2007)

Guidelines

NGC - Guidelines for the management of colorectal cancer. (2007)

NGC - Capecitabine and oxaliplatin in the adjuvant treatment of stage III (Dukes’ C) colon cancer. (2006)

NGC - Irinotecan, oxaliplatin and raltitrexed for the treatment of advanced colorectal cancer. (2005)

NGC - Laparoscopic surgery for colorectal cancer (review). (2006)

National Comprehensive Cancer Network (NCCN) Colon Cancer Guidelines, Version 1.2007

National Comprehensive Cancer Network (NCCN) Rectal Cancer Guidelines, Version 1.2007

NGC - The role of oxaliplatin combined with 5-fluorouracil and folinic acid in the first and second-line treatment of advanced colorectal cancer: a clinical practice guideline. (2006)

Immunotherapy

Internet Sites

Treatment Information

DrugBank (drug structure)

FDA - MedWatch (Drug Alerts)

NCI - Dictionary of Cancer Terms

NCI - Drug Dictionary

NCI - Overview of Nutrition in Cancer Care

Drug-Food-Supplement Information

Drug Information Online

Drug Interaction Checker

DrugDigest (drug interactions)

FDA - Drug Interactions: What You Should Know

NIH - Botanical Dietary Supplements: Background Information

NIH - Drug, Supplements, and Herbal Information

NIH - Herbal Supplements: Consider Safety, Too

NIH - Medicines

NIH - Vitamin and Mineral Supplement Fact Sheets

Nutrition

Guidelines for colorectal cancer: Effects on nutritional intervention. (Clin Nutr. 2007)

Diet Appears to Influence Colon Cancer Outcomes "Reporting in the August 15, 2007, issue of the Journal of the American Medical Association, researchers show that patients with the highest intake of a Western-pattern diet, characterized by high intakes of red meat, sugar desserts, high fat, and refined grains, have a 3-fold increase in cancer recurrences and mortality."

Colon cancer therapy: new perspectives of nutritional manipulations using polyunsaturated fatty acids. (Curr Opin Clin Nutr Metab Care. 2007)

Other

Radiation-Chemotherapy

Other Treatments

Experimental

Dietary omega-3-polyunsaturated fatty acids prevent the development of metastases of colon carcinoma in rat liver. (Eur J Nutr. 2007)

Radiotherapy

Supplements-Vitamins-CAM

Colon cancer therapy: new perspectives of nutritional manipulations using polyunsaturated fatty acids. (Curr Opin Clin Nutr Metab Care. 2007) "SUMMARY: New insights suggest that n-3 PUFAs may play an important role not only in cancer prevention but also in cancer management. They may act synergistically with radio/chemotherapy to kill tumour cells by increasing oxidative stress while reducing angiogenesis, inflammation and metastasis induction."

Surgery

Laparoscopic versus open colorectal resection for cancer: A meta-analysis of results of randomized controlled trials on recurrence. (Eur J Surg Oncol. 2007) “CONCLUSION: This meta-analysis supports that the recurrence rates for patients with colorectal cancer treated by laparoscopic surgery do not differ from those for open surgery. Longer follow-up studies will further define outcomes, comparing the two techniques in the treatment of colorectal cancer.”

[Surgical treatment of colon cancer] (Tidsskr Nor Laegeforen. 2007)

Clinical outcome of the laparoscopic surgery for stage II and III colorectal cancer. (Surg Endosc. 2007)

CT colonography for follow-up after surgery for colorectal cancer. (AJR Am J Roentgenol. 2007)

[Laparoscopic colon and rectal surgery--after ten years and 350 operations] (Harefuah. 2007)

Impact of surgeon volume and specialization on short-term outcomes in colorectal cancer surgery. (Br J Surg. 2007) "CONCLUSION:: High-volume surgeons had lower perioperative mortality rates for elective surgery, and were more likely to use restorative rectal procedures."

Transplantation

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