Frontotemporal Dementia - Pick's Disease

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Frontotemporal Dementia - Pick's Disease

Diagnosis, Imaging, and Screening

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11C-PIB PET imaging in Alzheimer disease and frontotemporal lobar degeneration (NEUROLOGY 2007)

A comparison of unawareness in frontotemporal dementia and Alzheimer's disease. (J Neurol Neurosurg Psychiatry. 2007)

A tensor based morphometry study of longitudinal gray matter contraction in FTD. (Neuroimage. 2007)

Accuracy of the Clinical Evaluation for Frontotemporal Dementia (Arch Neurol. 2007) "Conclusions Consensus criteria for FTD and neuropsychological measures lacked sensitivity for FTD; however, neuroimaging, particularly functional brain studies, greatly increased the sensitivity of detecting FTD. The clinical diagnosis of FTD needs to combine neuropsychiatric features with SPECT or PET findings while following the changes on neuropsychological tests."

Behavioural variant Frontotemporal Dementia: Not all it seems? (Neurocase. 2007)

Brain reserve capacity in frontotemporal dementia: a voxel-based (18)F-FDG PET study. (Eur J Nucl Med Mol Imaging. 2007)

Clinical and Psychometric Distinction of Frontotemporal and Alzheimer Dementias (Arch Neurol. 2007) "Conclusions Clinical and cognitive features of FTLD may overlap with AD, although behavioral and language difficulties distinguish those with FTLD. Memory loss in those with FTLD may in part reflect word-finding difficulties stemming from language dysfunction. Compounding the overlap of FTLD and AD clinical phenotypes is the presence of histopathological AD in almost one fourth of individuals with FTLD."

Clinical Features and Survival of 3R and 4R Tauopathies Presenting as Behavioral Variant Frontotemporal Dementia. (Alzheimer Dis Assoc Disord. 2007)

Clinical Significance of Lobar Atrophy in Frontotemporal Dementia: Application of an MRI Visual Rating Scale (Dementia and Geriatric Cognitive Disorders 2007)

Deformation-Based Morphometry Reveals Brain Atrophy in Frontotemporal Dementia (Arch Neurol. 2007) "Conclusions We confirmed frontal and anterior temporal gray matter atrophy in FTD. The observed white matter loss, thalamic involvement, and midbrain atrophy are consistent with pathological findings in late-stage FTD. Dysfunction of ventral-frontal-brainstem circuitry may underlie some of the unique clinical features of FTD."

Different regional patterns of cortical thinning in Alzheimer's disease and frontotemporal dementia. (Brain. 2007) "In conclusion, the characteristic patterns of cortical thinning in Alzheimer's disease and FTD suggest that cortical thickness may be a useful surrogate marker for these types of dementia."

Distinct Antemortem Profiles in Patients With Pathologically Defined Frontotemporal Dementia (Arch Neurol. 2007) "Distinguishing features of patients with tau-positive FTD include visual perceptual-spatial difficulty and an extrapyramidal disorder significantly more often than other patients, significant cortical atrophy in the frontal and parietal regions as evidenced on MRI, and the burden of pathology is greatest in the frontal and parietal regions. Patients with tau-negative FTD are distinguished by their greater difficulties with social, language, and verbally mediated executive functions, significant cortical atrophy in the frontal and temporal regions as evidenced on MRI, and significant frontal and temporal pathology. Patients with Alzheimer disease at autopsy have significantly impaired delayed recall during episodic memory testing; atrophy that involves temporal areas, including the hippocampus, as evidenced on MRI; and widely distributed pathology including the medial temporal structures."

Evidence of White Matter Changes on Diffusion Tensor Imaging in Frontotemporal Dementia (Arch Neurol 2007)

Extrapyramidal signs, primitive reflexes and incontinence in fronto-temporal dementia. (Eur J Neurol. 2007)

FDG-PET improves accuracy in distinguishing frontotemporal dementia and Alzheimer's disease. (Brain. 2007)

Frontotemporal dementia and semantic dementia: anatomic variations on the same disease or distinctive entities? (Alzheimer Dis Assoc Disord. 2007)

Odor identification deficits in frontotemporal dementia: A preliminary study. (Arch Clin Neuropsychol. 2007) "This preliminary research demonstrates olfactory deficits in FTD, which appear to be similar in magnitude to the olfactory deficits seen in AD."

Patterns of White Matter Atrophy in Frontotemporal Lobar Degeneration (Arch Neurol. 2007) "Conclusions These results show that patients with frontotemporal lobar degeneration who are in relatively early stages of the disease (Clinical Dementia Rating score, 1.0-1.2) have WM atrophy that largely parallels the pattern of GM atrophy typically associated with these disorders."

Screening for Frontotemporal Dementias and Alzheimer's Disease with the Philadelphia Brief Assessment of Cognition: A Preliminary Analysis. (Dement Geriatr Cogn Disord. 2007)

The Diagnosis and Course of Frontotemporal Dementia. (Alzheimer Disease & Associated Disorders 2007)

The many ways to frontotemporal degeneration and beyond. (Neurol Sci. 2007) "RESULTS: FTD presents with many phenotypes that span from prefrontal syndromes to lower motor neuron disease passing through temporal, partietal and extrapyramidal syndromes. FTD includes the frontotemporal lobar atrophies clinically characterised by abnormal behaviour, progressive aphasia or semantic dementia, as well as corticobasal degeneration, progressive supranuclear palsy, progressive subcortical gliosis and FTD with motor neuron disease."

Utility of Behavioral versus Cognitive Measures in Differentiating between Subtypes of Frontotemporal Lobar Degeneration and Alzheimer's Disease. (Dement Geriatr Cogn Disord. 2007)

Voxel-Based Morphometry in Frontotemporal Lobar Degeneration With Ubiquitin-Positive Inclusions With and Without Progranulin Mutations (Arch Neurol. 2007) "Conclusion Findings from this study suggest that PGRN mutations may be associated with a specific and severe pattern of cerebral atrophy in subjects with FTLD-U."

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