Multiple Sclerosis

Treatment is updated daily with the most recent articles listed on top.
To view only the last month's articles for the other sub-topics, go to our Monthly Online Newsletters page

If you have any questions regarding our Search Reports, please contact us at info@infomedsearch.com.

Multiple Sclerosis

NIH - Medical Encyclopedia Multiple Sclerosis

"Multiple sclerosis (MS) usually affects woman more than men. The disorder most commonly begins between ages 20 and 40, but can strike at any age. The exact cause is not known, but MS is believed to result from damage to the myelin sheath, the protective material which surrounds nerve cells. It is a progressive disease, meaning the damage gets worse over time. Inflammation destroys the myelin, leaving multiple areas of scar tissue (sclerosis). The inflammation occurs when the body's own immune cells attack the nervous system. The inflammation causes nerve impulses to slow down or become blocked, leading to the symptoms of MS. Repeated episodes, or flare ups, of inflammation can occur along any area of the brain and spinal cord."

Highlighted Article

The role of MRI in the diagnosis of multiple sclerosis. (Adv Neurol. 2006)

"There is no single test that is diagnostic of MS, including MRI. The lesions detected with MRI are pathologically nonspecific. The principles of MS diagnosis are based on showing dissemination of white matter lesions in space and time. … The first important role for MRI in the diagnosis of MS allows for an early diagnosis of MS … The second important role for MRI in the diagnostic work-up of suspected MS patients is to rule out alternative diagnoses obvious on MRI, such as spinal stenosis and most brain tumors. Characteristic lesions that favor MS include Dawson Fingers, ovoid lesions, corpus callosum lesions, and asymptomatic spinal cord lesions. However, other white matter diseases can have similar appearances on MRI. … MRI evidence plays a supportive role in what is ultimately a clinical diagnosis of MS, in the appropriate clinical situation, and always at the exclusion of alternative diagnoses."

CONTINUE YOUR INFOMEDSEARCH RESEARCH with our previous InfoMedLinks. Start with InfoMedLinks 2006.

Multiple Sclerosis

Diagnosis, Imaging, and Screening

NEWS:

Brain Lesions Predict MS Progression "The two most common types of multiple sclerosis are called relapsing-remitting and secondary-progressive disease. People with relapsing-remitting MS have flare-ups of symptoms, followed by periods when the disease does not worsen. Those with secondary-progressive MS have a period of relapsing-remitting disease and then get steadily worse. … The more T1 hyperintense lesions a person had, the more likely they were to be physically disabled, to have disease progression and to have brain atrophy, another marker of the disease."

Cognitive impairment in relapsing-remitting multiple sclerosis can be predicted by imaging performed several years earlier. (Mult Scler. 2007)

Detection of Cortical Inflammatory Lesions by Double Inversion Recovery Magnetic Resonance Imaging in Patients With Multiple Sclerosis (Arch Neurol. 2007) "Background A significant inflammatory pathologic disorder in the cortex of patients with multiple sclerosis (MS) has been demonstrated by ex vivo studies. … Conclusions Although more frequent in patients with SPMS, ICLs were observed from the early disease stages. The ICLs were more frequently detected in patients with IgGOBs and were associated with a higher clinical disability score and male sex. The ICLs may help to define MS clinical heterogeneity and prognosis in clinical settings."

MRI May Predict Multiple Sclerosis' Effect on Brain

ARTICLES:

Diagnosing MS

JOURNAL ARTICLES:

Association of Neocortical Volume Changes With Cognitive Deterioration in Relapsing-Remitting Multiple Sclerosis (Arch Neurol. 2007) "Conclusion Progressive neocortical gray matter loss is relevant to MS-associated cognitive impairment and may represent a sensitive marker of deteriorating cognitive performance in RRMS."

Associations Between Cervical Cord Gray Matter Damage and Disability in Patients With Multiple Sclerosis (Arch Neurol. 2007) "Conclusions Cervical cord gray matter is not spared by MS pathology, and such damage is an additional factor contributing to the disability of these patients."

Axonal damage in the spinal cord of multiple sclerosis patients detected by magnetic resonance spectroscopy. (Magn Reson Med. 2007) "MRS demonstrated cellular damage within the cord over and above the tissue atrophy seen by MRI. Combining MRI and MRS may therefore give a more complete picture of neurodegeneration in the spinal cord."

Clinical features of children and adolescents with multiple sclerosis. (Neurology. 2007)

Deep Gray Matter Perfusion in Multiple Sclerosis (Arch Neurol. 2007) "Conclusion The decrease of tissue perfusion in the deep gray matter of patients with MS is associated with the severity of fatigue."

Determinants of Cerebral Atrophy Rate at the Time of Diagnosis of Multiple Sclerosis (Arch Neurol. 2007) "Conclusions In patients with recently diagnosed multiple sclerosis, the extent of accumulated brain tissue loss and overall lesion load partly explain the subsequent rate of cerebral atrophy."

Differential diagnosis and evaluation in pediatric multiple sclerosis. (Neurology. 2007)

Differential diagnosis of multiple sclerosis. (Int Rev Neurobiol. 2007) "Typically, MS presents itself in individuals in their teens up to their late 30s. On occasion, however, one can see MS present in patients in their 60s. However, in retrospect, many of these patients might have had subtle manifestations of MS in their younger years. Visual obscuration or visual loss can be a manifestation of retinal ischemia, retinal migraine, or optic neuritis which might or might not evolve into a clinical picture compatible with MS. Cranial neuropathy, long tract signs, sensory disturbance, and/or gait ataxia can be related to a number of different processes such as illicit drug use, neurosarcoidosis, neuro-Behcet's disease, neuroborreliosis, HIV-related disease, neurosyphilis, vascular occlusive disease including vasculitis, connective tissue disorders, acute disseminated encephalomyelitis (ADEM), idiopathic transverse myelitis, neuromyelitis optica (NMO), or tropical spastic paraparesis."

Diffusion tensor MRI in multiple sclerosis. (J Neuroimaging. 2007)

Gray matter involvement in multiple sclerosis (NEUROLOGY 2007)

Magnetic resonance imaging of the brain used to detect early post-partum activation of multiple sclerosis (European Journal of Neurology 2007) "The clinical and MRI findings indicate that post-partum activation is an early and common phenomenon amongst mothers with MS."

Measuring brain atrophy in multiple sclerosis. (J Neuroimaging. 2007)

MRI features of pediatric multiple sclerosis. (Neurology. 2007)

Normal-appearing grey and white matter T1 abnormality in early relapsing-remitting multiple sclerosis: a longitudinal study. (Mult Scler. 2007)

Quantitative Assessment of Iron Accumulation in the Deep Gray Matter of Multiple Sclerosis by Magnetic Field Correlation Imaging (American Journal of Neuroradiology 2007)

Relationships between gray matter metabolic abnormalities and white matter inflammation in patients at the very early stage of MS : A MRSI study. (J Neurol. 2007)

Thalamic atrophy and cognition in multiple sclerosis (NEUROLOGY 2007) "Conclusion: These findings suggest that thalamic atrophy is a clinically relevant biomarker of the neurodegenerative disease process in multiple sclerosis."

The role of MRI of the brain and spinal cord, and CSF examination for the diagnosis of primary progressive multiple sclerosis (European Journal of Neurology 2007)

Go to the top