NeuroDegeneration
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NeuroDegeneration
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JOURNAL ARTICLES:
Calcium and neurodegeneration. (Aging Cell. 2007) "When properly controlled, Ca(2+) fluxes across the plasma membrane and between intracellular compartments play critical roles in fundamental functions of neurons, including the regulation of neurite outgrowth and synaptogenesis, synaptic transmission and plasticity, and cell survival. During aging, and particularly in neurodegenerative disorders, cellular Ca(2+)-regulating systems are compromised resulting in synaptic dysfunction, impaired plasticity and neuronal degeneration."
Coenzyme Q treatment of neurodegenerative diseases of aging. (Mitochondrion. 2007) "The etiology of several neurodegenerative disorders is thought to involve impaired mitochondrial function and oxidative stress. Coenzyme Q-10 (CoQ(10)) acts both as an antioxidant and as an electron acceptor at the level of the mitochondria. In several animal models of neurodegenerative diseases including amyotrophic lateral sclerosis, Huntington's disease, and Parkinson's disease, CoQ(10) has shown beneficial effects."
Mitochondria and Neurodegeneration. (Biosci Rep. 2007)
Neuronal Damage in Brain Inflammation (Arch Neurol. 2007)
Progressive damage after brain and spinal cord injury: pathomechanisms and treatment strategies. (Prog Brain Res. 2007)
Stress, Aging, and Neurodegenerative Disease (NEJM 2007)
Systemic infections and inflammation affect chronic neurodegeneration. (Nat Rev Immunol. 2007) "Here we review evidence to support our hypothesis that in chronic neurodegenerative diseases such as Alzheimer's disease, with an ongoing innate immune response in the brain, systemic infections and inflammation can cause acute exacerbations of symptoms and drive the progression of neurodegeneration."
Tauopathies (Cell Mol Life Sci. 2007) "Tau is a microtubule-associated protein predominantly expressed in nerve cells that promote microtubule assembly and microtubule stabilization. Tau is a cytosolic protein mainly present in axons and involved in anterograde axonal transport. In several neurodegenerative diseases, as for example Alzheimer's disease, tau metabolism is altered. Thus, alterations in the amount of the tau protein, missense mutations, posttranscriptional modifications like phosphorylation, aberrant tau aggregation or a different expression of some of its isoforms could provoke pathological effects resulting in the appearance of neuronal disorders known as tauopathies."
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