Neuropathy

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Neuropathy

General Information

NEWS:

From the 67th annual scientific sessions of the American Diabetes Association: Lipid-lowering therapies reduce development of peripheral neuropathy "Statins and fibrates reduce the risk of peripheral neuropathy in patients with type 2 diabetes independent of the agents' effects on lipids, according to Timothy Davis, MD, PhD, professor of medicine, University of Western Australia."

ARTICLES:

Peripheral Neuropathy & Diabetes: Risk Factors & Symptoms

JOURNAL ARTICLES:

Acute compression of the median nerve at the elbow by the lacertus fibrosus (Journal of Shoulder and Elbow Surgery 2007) "Symptoms of chronic compressive peripheral neuropathy consist predominantly of an achy feeling, paresthesias, numbness, and a sense of weakness or fatigue, with the onset being insidious and frequently without a precipitating cause."

Acute Motor Axonal Neuropathy–An Atypical Presentation (Pediatric Neurology 2007)

Anterior Ischemic Optic Neuropathy in Patients Younger than 50 Years. (Am J Ophthalmol. 2007)

Approach to the patient with chronic polyneuropathy (Acta Neurologica Scandinavica 2007) " Results – All patients should undergo a routine investigation for the most common causes of polyneuropathy by asking for diabetes, heredity, alcohol abuse, toxic medications and agents, symptoms of Sjögren's syndrome, renal failure, and the following laboratory tests; glucose, haemoglobin, leucocytes, thrombocytes, ESR, creatinin, ALAT, GT, vitamin B12, serum electrophoresis, TSH and thyroxin. If routine investigation is negative, a targeted approach based on clinical type and electrophysiological findings is recommended. The most common type with slowly progressive, symmetric sensory symptoms beginning in the feet can often be classified as cryptogenic without further investigation."

Bell's Palsy: Diagnosis and Management (Am Fam Physician 2007)

[Cardiovascular impact of the autonomic neuropathy of diabetes mellitus.] (Arq Bras Endocrinol Metabol. 2007)

Celiac disease presenting with motor neuropathy: Effect of gluten free-diet. (Muscle Nerve. 2007)

Classifications and treatment responses in chronic immune-mediated demyelinating polyneuropathy. (Neurology. 2007)

Diabetic neuropathy--a review. (Nat Clin Pract Neurol. 2007) "The vast majority of patients with clinical diabetic neuropathy have a distal symmetrical form of the disorder that progresses following a fiber-length-dependent pattern, with sensory and autonomic manifestations predominating. This pattern of neuropathy is associated with a progressive distal axonopathy. Patients experience pain, trophic changes in the feet, and autonomic disturbances. Occasionally, patients with diabetes can develop focal and multifocal neuropathies that include cranial nerve involvement and limb and truncal neuropathies. This neuropathic pattern tends to occur after 50 years of age, and mostly in patients with long-standing diabetes mellitus."

Diabetic painful neuropathy: current and future treatment options. (Drugs. 2007) "Diabetic painful neuropathy (DPN) is one of the most common causes of neuropathic pain. The management of DPN consists of excluding other causes of painful peripheral neuropathy, maximising diabetic control and using medications to alleviate pain.The precise relationship between glycaemic control and the development and severity of DPN remains controversial. In this context, drugs such as aldose reductase inhibitors, ACE inhibitors, lipid-lowering agents and alpha-lipoic acid (thioctic acid) may have a useful role to play."

Early diabetic neuropathy: Triggers and mechanisms. (World J Gastroenterol. 2007) "Some symptoms of DPN may develop with little, if any, correlation with the glycemic status of a patient. It is also clear that identification of these putative non-glycemic mechanisms of DPN is of utmost importance for our understanding of failures with existing treatments and for the development of new approaches for diagnosis and therapy of DPN."

Estimated prevalence of peripheral neuropathy and associated pain in adults with diabetes in France. (Curr Med Res Opin. 2007) "CONCLUSION: This study concluded that 8% of participants with diabetes in France had pDPN."

Falls and gait characteristics among older persons with peripheral neuropathy. (Am J Phys Med Rehabil. 2007) "CONCLUSIONS: Older patients with peripheral neuropathy have a high rate of falls, and these falls are often associated with walking on irregular surfaces. Gait analysis on an irregular surface may be superior to that on a smooth surface for detecting fall risk in this patient population."

Genotype-phenotype analysis in patients with giant axonal neuropathy (GAN). (Neuromuscul Disord. 2007)

Hereditary sensory and autonomic neuropathies: types II, III, and IV. (Orphanet J Rare Dis. 2007)

Hypertension and Sensorimotor Peripheral Neuropathy in Type 2 Diabetes (European Neurology 2007) "Conclusions: There is a strong association between hypertension and SMPN in type 2 diabetic patients with relatively short duration of disease. This relationship is independent of other risk factors."

Hypertrophic mononeuropathy (Neurosurgical Focus 2007)

Idiopathic chronic inflammatory demyelinating polyneuropathy: an epidemiologic study in Italy. (J Neurol Neurosurg Psychiatry. 2007)

Infectious neuropathy. (Current Opinion in Neurology 2007)

Ischaemic optic neuropathy: the Singapore scene. (Singapore Med J. 2007)

Multifocal motor neuropathy: the diagnostic spectrum and response to treatment. (Neurology. 2007)

Neuropathies associated with conduction block. (Current Opinion in Neurology 2007)

Neuropathies in the older patient (Reviews in Clinical Gerontology (2006/2007) ) "The elderly population is at higher risk of peripheral neuropathy, as there is a correlation between age and impairment of the peripheral nervous system. The natural aging process affects adversely the function of peripheral nerves and of their target organs, resulting in the development of motor, sensory and autonomic symptoms in the absence of additional damage of other causes. In addition, the increased prevalence of chronic systemic disorders causing neuropathy, as well as the use of neurotoxic drugs in older patients, contribute to the onset of neuropathy."

Neuropathies of the foot. (Clin Neurophysiol. 2007)

Peripheral neuropathy in patients with diabetic foot ulcers: Clinical and nerve conduction study. (J Neurol Sci. 2007) "CONCLUSIONS: Our results indicate that male gender, motor neuropathy and mononeuropathies, especially ulnar neuropathy is associated with the development of DF among our patients with DF. Patients with diabetes mellitus have a predisposition to develop chronic inflammatory demyelinating polyneuropathy and this may also facilitate formation of diabetic foot. History of hemiplegia, dementia and trauma are permissive risk factors for diabetic foot in the presence of mild polyneuropathy."

Phenotype of Charcot-Marie-Tooth disease Type 2. (Neurology. 2007)

Prevalence and the associated burden of illness of symptoms of diabetic peripheral neuropathy and diabetic retinopathy. (J Diabetes Complications. 2007)

Prevalence of and risk factors for HIV-associated neuropathy in Melbourne, Australia 1993-2006. (HIV Med. 2007)

Prognostic values of electrodiagnostic studies in traumatic radial neuropathy. (Muscle Nerve. 2007)

[Pure motor neuropathy, an uncommon complication of radiotherapy: report of 3 cases and review of the literature.] (Rev Med Interne. 2007)

Restless legs syndrome in diabetic neuropathy: a frequent manifestation of small fiber neuropathy. (J Peripher Nerv Syst. 2007) "Our data show that RLS is a relevant feature of diabetic neuropathy, as a frequent and potentially treatable manifestation of small fiber involvement in the course of DM and IGT/IFG."

"Silent" bone stress injuries in the feet of diabetic patients with polyneuropathy: a report on 12 cases. (Arch Orthop Trauma Surg. 2007) "CONCLUSIONS: In diabetic patients with polyneuropathy, symptoms of bone stress injuries of the foot are atypical, in that there is load-related swelling rather than load-related pain. Immediate diagnosis, and treatment with off-loading, leads to a restitutio ad integrum like in non-neuropathic patients. Delayed cessation of overuse, however, may cause irreversible joint and bone damage (Charcot foot)."

[The entrapment neuropathy: a treatable cause of musculoskeletal pain] (Rev Med Suisse. 2007)

Time course of axonal regeneration in acute motor axonal neuropathy. (Muscle Nerve. 2007)

Vasculitic neuropathies: an update. (Neurologist. 2007) "Most patients have clinical features of a subacute, progressive, generalized but asymmetric, painful, sensorimotor polyneuropathy. Laboratory tests often indicate features of systemic inflammation, such as an elevated sedimentation rate or positive anti-neutrophil cytoplasmic antibody, and electrodiagnostic evaluation shows multiple mononeuropathies or a confluent, asymmetric axonal neuropathy. Nerve biopsy is necessary to establish the diagnosis in most cases, particularly in patients with NSVN. This review summarizes the current treatment of vasculitic neuropathy."

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