Pregnancy

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Pregnancy

Pre-Eclampsia

NEWS:

Aspirin May Cut Pregnancy Complication Risk "Women at high risk for the pregnancy complication preeclampsia can lower their odds by 10 percent by taking daily aspirin, a new study suggests. Preeclampsia is a potentially fatal obstetric complication that can lead to sudden high blood pressure and irregular blood flow. This can activate platelets and the clotting system, which in turn slows blood flow."

Calcium supplements ward of pregnancy complication "Pregnant women who take calcium supplements reduce their risk of developing preeclampsia, sometimes called toxemia of pregnancy, according to a new study. However, calcium supplementation has no effect on the risk of preterm birth or stillbirth."

High BP in Pregnancy Increases Risk for Future Atherosclerosis "Women who have gestational hypertension are at increased risk of developing atherosclerosis when they are older, new research shows"

ARTICLES:

Chronic Hypertension in Pregnancy

JOURNAL ARTICLES:

Antihypertensive drug therapy for mild to moderate hypertension during pregnancy. (Cochrane Database Syst Rev. 2007)

Antiplatelet agents for preventing pre-eclampsia and its complications. (Cochrane Database Syst Rev. 2007) "AUTHORS' CONCLUSIONS: Antiplatelet agents, largely low-dose aspirin, have moderate benefits when used for prevention of pre-eclampsia and its consequences. Further information is required to assess which women are most likely to benefit, when treatment is best started, and at what dose."

Antiplatelet agents for prevention of pre-eclampsia: a meta-analysis of individual patient data. (Lancet. 2007)

[Current recommendations for the treatment of preeclampsia] (Gynakol Geburtshilfliche Rundsch. 2007)

Diuretics for preventing pre-eclampsia. (Cochrane Database Syst Rev. 2007) "AUTHORS' CONCLUSIONS: There is insufficient evidence to draw reliable conclusions about the effects of diuretics on prevention of pre-eclampsia and its complications. However, from this review, no clear benefits have been found from the use of diuretics to prevent pre-eclampsia. Taken together with the level of adverse effects found, the use of diuretics for the prevention of pre-eclampsia and its complications cannot be recommended."

Emotional stress and the risk to develop hypertensive diseases in pregnancy. (Hypertens Pregnancy. 2007) "Results: Emotional stress during pregnancy was associated with a 1.6-fold increased risk for HDP. Conclusion: Psychosocial interventions to reduce emotional stress during pregnancy may help to decrease the risk to develop HDP."

Evidence-based management for preeclampsia. (Front Biosci. 2007)

High Blood Pressure in Pregnancy and Coronary Calcification. (Hypertension. 2007) " We concluded that high blood pressure during pregnancy is associated with an increased risk of coronary calcification later in life."

Hypertension in pregnancy. (Adv Chronic Kidney Dis. 2007) "Hypertensive disorders of pregnancy are the most common medical disorders of pregnancy and are associated with increased maternal and perinatal risks. The pathophysiology, diagnosis, and treatment are herein reviewed for chronic hypertension, preeclampsia, gestational hypertension, and severe hypertension.. Women may remain hypertensive for a period postpartum and require treatment for a short interval. Early or severe preeclampsia warrants workup postpartum for secondary causes. Pregnancy induced hypertension or preeclampsia are emerging as risk factors for future cardiovascular risk."

Hypertension in pregnancy: an emerging risk factor for cardiovascular disease. (Nat Clin Pract Nephrol. 2007)

Maternal mortality due to eclamptic and non-eclamptic hypertensive disorders: A challenge. (J Obstet Gynaecol. 2007) "Eclamptic and non-eclamptic hypertensive disorders are responsible for high maternal and perinatal mortality, especially in developing countries. The present study was done in order to understand the trends of maternal deaths due to non-eclamptic and eclamptic hypertensive disorders by analysis of case records of women who died due to these disorders over a period of 20 years. . The most common cause of mortality in cases of pre-eclampsia was haemolysis, elevated liver enzymes, and low platelet count (HELLP) or partial HELLP syndrome (83.33%) and in eclampsia, pulmonary oedema. Even with resource constraints, mortality due to eclampsia can be reduced with appropriate and timely therapy. Evidence-based critical care is essential as even seemingly milder forms of pregnancy induced hypertension can lead to mortality."

Maternal serum highly sensitive C-reactive protein in normal pregnancy and pre-eclampsia. (Int J Gynaecol Obstet. 2007) "CONCLUSIONS: This study showed that hsCRP levels were positively correlated to pregnancy duration in healthy women and could be used as a severity marker in women with severe PE."

Maternal vitamin D deficiency increases the risk of preeclampsia. (J Clin Endocrinol Metab. 2007) "Conclusions: Maternal vitamin D deficiency may be an independent risk factor for preeclampsia. Vitamin D supplementation in early pregnancy should be explored for preventing preeclampsia and promoting neonatal well-being."

Nitric oxide for preventing pre-eclampsia and its complications. (Cochrane Database Syst Rev. 2007) "AUTHORS' CONCLUSIONS: There is insufficient evidence to draw reliable conclusions about whether nitric oxide donors and precursors prevent pre-eclampsia or its complications."

Preeclampsia and future cardiovascular risk. (Expert Rev Cardiovasc Ther. 2007) "Pregnancy is a metabolic and vascular 'stress test' for women and those who 'fail' are at increased risk of long-term cardiovascular complications. Specifically, women who develop preeclampsia (and/or other manifestations of placental dysfunction) are at increased risk of coronary heart disease, stroke and cardiovascular disease in general. The risk is highest among women who develop both maternal (e.g., hypertension and proteinuria) and fetal (e.g., intrauterine growth restriction) manifestations of abnormal placentation, especially with preterm delivery."

[Preeclampsia as a maternal vascular disease] (Harefuah. 2007) "Preeclampsia, one of the main complications in pregnancy, affects 5-7% of all pregnancies, and is a leading cause of maternal and perinatal mortality. The placenta plays a pivotal role in the etiology of preeclampsia, and particularly, the trophoblast cells of the placenta. It is now believed that preeclampsia is a two stage disease. …"

Preeclampsia: at risk for remote cardiovascular disease. (Am J Med Sci. 2007)

Pre-eclampsia and nasal CPAP: Part 1. Early intervention with nasal CPAP in pregnant women with risk-factors for pre-eclampsia: Preliminary findings. (Sleep Med. 2007)

Pre-eclampsia and nasal CPAP: Part 2. Hypertension during pregnancy, chronic snoring, and early nasal CPAP intervention. (Sleep Med. 2007)

[Prophylactic treatment of preeclampsia] (Gynakol Geburtshilfliche Rundsch. 2007)

Self-Reported Snoring, Maternal Obesity and Neck Circumference as Risk Factors for Pregnancy-Induced Hypertension and Preeclampsia. (Respiration. 2007)

Why much of the pathophysiology of preeclampsia-eclampsia must be of an autoimmune nature. (Am J Obstet Gynecol. 2007) "Preeclampsia-eclampsia (PE-E) is a poorly understood condition of human pregnancy, which can affect multiple organs and is a leading cause of maternal deaths worldwide."

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