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Sleep Apnea
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Sleep ApneaGeneral InformationNEWS:Sleep apnea may boost blood carbon dioxide levels “People who suffer from the nighttime breathing disorder known as sleep apnea may develop high levels of carbon dioxide in the blood during the daytime -- a condition known as hypercapnia, Japanese researchers have found.” Sleepless Kids Are Troubled Kids "The nightly trip to dreamland is a frustrating one for millions of American children suffering from insomnia, night awakenings and even sleep apnea, experts say." ARTICLES:JOURNAL ARTICLES:Association of physical activity with sleep-disordered breathing. (Sleep Breath. 2007) Central sleep apnea: Pathophysiology and treatment. (Chest. 2007) "Central sleep apnea (CSA) is characterized by a lack of drive to breathe during sleep, resulting in repetitive periods of insufficient ventilation and compromised gas exchange. These nighttime breathing disturbances can lead to important comorbidity and increased risk of adverse cardiovascular outcomes. There are several manifestations of CSA, including high altitude-induced periodic breathing, idiopathic CSA, narcotic-induced central apnea, obesity hypoventilation syndrome, and Cheyne-Stokes breathing. While unstable ventilatory control during sleep is the hallmark of CSA, the pathophysiology and the prevalence of the various forms of CSA vary greatly." C-reactive protein is associated with sleep disordered breathing independent of adiposity. (Sleep. 2007) Familial premature coronary artery disease mortality and obstructive sleep apnea. (Chest. 2007) " CONCLUSIONS: Regardless of their own CAD status, people with OSA are more likely than those without OSA to have a family history of premature CAD mortality." Inflammation and oxidative stress in obstructive sleep apnea syndrome. (Exp Biol Med (Maywood). 2007) Is excessive daytime sleepiness a predictor of carotid atherosclerosis in sleep apnea? (Atherosclerosis. 2007) "CONCLUSION: EDS is associated with obesity, diabetes and all respiratory variables in OSA patients and may serve as an independent predictor of carotid atherosclerosis before polysomnography." Mortality risk factors in sleep apnoea: a matched case-control study. (J Sleep Res. 2007) "Chronic upper airway problems were associated with survival (OR: 0.45, 95% CI 0.23-0.90). There were significant interactions between respiratory disturbance index and BMI and COPD. Mortality of patients younger than the median age (62 years) was associated with COPD, DM and an interaction between BMI and apnoea severity. Predictors of mortality for the older patients were COPD, CHF and DM. We conclude that all-cause mortality in sleep apnoea is associated with co-morbidities and obesity. Severity of sleep apnoea affects mortality by interacting with obesity and lung disease." Nocturnal cardiac arrhythmia in patients with obstructive sleep apnea. (Sleep Med. 2007 ) Obesity, and not obstructive sleep apnea, is responsible for increased serum hs-CRP levels in patients with sleep-disordered breathing in Delhi. (Sleep Med. 2007) "CONCLUSIONS: In this first comprehensive cross-sectional study on Indian subjects, we found that obesity, and not obstructive sleep apnea, is associated with elevated serum levels of hs-CRP. No independent correlation was found between severity of OSA and hs-CRP in the present study." Obstructive sleep apnea and coronary artery disease. (Sleep Med Rev. 2007) Obstructive sleep apnea is associated with seizure occurrence in older adults with epilepsy. (Neurology. 2007) Obstructive sleep apnea, obesity, and the risk of incident atrial fibrillation. (J Am Coll Cardiol. 2007) "CONCLUSIONS: Obesity and the magnitude of nocturnal oxygen desaturation, which is an important pathophysiological consequence of OSA, are independent risk factors for incident AF in individuals <65 years of age" Obstructive sleep apnoea: a cause of chronic cough. (Cough. 2007) Obstructive sleep apnea: An update on mechanisms and cardiovascular consequences. (Nutr Metab Cardiovasc Dis. 2007) "CONCLUSION: Patients with OSA are at increased risk for cardiovascular disease. OSA should be considered in the differential diagnosis of hypertensive patients who are obese. In particular, OSA should be excluded in patients with hypertension resistant to conventional drug therapy." Reduced language abilities in adolescents who snore. (Arch Clin Neuropsychol. 2007) Reduced Time in Bed and Obstructive Sleep-Disordered Breathing in Children Are Associated With Cognitive Impairment (PEDIATRICS 2007) "CONCLUSIONS. Short or variable time in bed and nightly snoring or higher apnea hypopnea index predicted impaired vocabulary and similarities scores in children with adenotonsillar hypertrophy suspected of having obstructive sleep-disordered breathing. The degree of cognitive impairment attributable to short time in bed and obstructive sleep-disordered breathing is clinically very significant." Refractory chronic headache associated with obstructive sleep apnoea syndrome. (Cephalalgia. 2007) [Sleep Apnoea in Women? - The Forgotten Gender.] (Pneumologie. 2007) Sleep apnea is associated with bronchial inflammation and continuous positive airway pressure-induced airway hyperresponsiveness. (J Allergy Clin Immunol. 2007) "CONCLUSION: Obstructive sleep apnea syndrome is associated with bronchial inflammation. Our data demonstrate CPAP effect on the development of AHR, possibly facilitated by the pre-existing inflammation. Both issues should be evaluated during long-term CPAP use. CLINICAL IMPLICATIONS: Results showing a spontaneous bronchial inflammation in OSA and the development of a CPAP-related AHR require a long-term follow-up to evaluate consequences on chronic bronchial obstruction." Sleep Apnea: Implications for Heart Failure. (Curr Heart Fail Rep. 2007) Sleep Apnea-Hypopnea Syndromes and Heart Failure (Rev Esp Cardiol. 2007) Smoking interacts with sleep apnea to increase cardiovascular risk. (Sleep Med. 2007) "CONCLUSION: There is a synergistic effect between cigarette smoking and sleep apnea on some of the biochemical cardiovascular risk markers. Patients with severe sleep apnea who smoke are at a greater cardiovascular risk than smokers with mild-moderate sleep apnea and patients who do not smoke." The relevance of sleep abnormalities to chronic inflammatory conditions. (Inflamm Res. 2007) The role of the nose in the pathogenesis of obstructive sleep apnoea and snoring. (Eur Respir J. 2007) |
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