Supplements - Nutrition

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Supplements - Nutrition

Curcumin

NEWS:

Curcumin May Treat Prostate Cancer "The ingredient curcumin -- found in the common curry spice, turmeric -- may help treat prostate cancer. In the most recent issue of Cancer Research, researchers from the Comprehensive Cancer Center of the University of Alabama in Birmingham report curcumin has anticancer effects. "

ARTICLES:

JOURNAL ARTICLES:

Antitumor, anti-invasion, and antimetastatic effects of curcumin. (Adv Exp Med Biol. 2007) "These results indicate that curcumin acts at various stages of tumor cell progression."

Beneficial role of curcumin in skin diseases. (Adv Exp Med Biol. 2007)

Cardioprotective effects of curcumin. (Adv Exp Med Biol. 2007) "Curcumin, a major active component of turmeric, is extracted from the powdered dry rhizome of Curcuma longa Linn (Zingiberaceae) and it has been used for centuries in indigenous medicine. We have shown that curcumin has a protective role against myocardial necrosis in rats. The antioxidant activity of curcumin could be attributed to the phenolic and methoxy groups in conjunction with the 1,3-diketone-conjugated diene system, for scavenging of the oxygen radicals. In addition, curcumin is shown to enhance the activities of detoxifying enzymes such as glutathione-S-transferase in vivo. We have also shown that oxygen free radicals exacerbate cardiac damage and curcumin induces cardioprotective effect and it also inhibits free-radical generation in myocardial ischemia in rats."

Clinical studies with curcumin. (Adv Exp Med Biol. 2007) "The pharmacokinetic studies of curcumin indicated in general a low bioavailability of curcumin following oral application. Nevertheless, the pharmacologically active concentration of curcumin could be achieved in colorectal tissue in patients taking curcumin orally and might also be achievable in tissues such as skin and oral mucosa, which are directly exposed to the drugs applied locally or topically. The effect of curcumin was studied in patients with rheumatoid arthritis, inflammatory eye diseases, inflammatory bowel disease, chronic pancreatitis, psoriasis, hyperlipidemia, and cancers. Although the preliminary results did support the efficacy of curcumin in these diseases, the data to date are all preliminary and not conclusive."

Curcumin and autoimmune disease. (Adv Exp Med Biol. 2007) "Although the beneficial effects of nutraceuticals are traditionally achieved through dietary consumption at low levels for long periods of time, the use of purified active compounds such as curcumin at higher doses for therapeutic purposes needs extreme caution. A precise understanding of effective dose, safe regiment, and mechanism of action is required for the use of curcumin in the treatment of human autoimmune diseases."

Curcumin as an inhibitor of angiogenesis. (Adv Exp Med Biol. 2007)

Curcumin as "Curecumin": From kitchen to clinic. (Biochem Pharmacol. 2007)

Curcumin effects on inflammation and performance recovery following eccentric exercise-induced muscle damage. (Am J Physiol Regul Integr Comp Physiol. 2007) "These results support the hypothesis that curcumin can reduce inflammation and offset some of the performance deficits associated with eccentric exercise-induced muscle damage."

Curcumin for chemoprevention of colon cancer. (Cancer Lett. 2007)

Curcumin in Cell Death Processes: A Challenge for CAM of Age-Related Pathologies. (Evid Based Complement Alternat Med. 2007)

Curcumin reverses breast tumor exosomes mediated immune suppression of NK cell tumor cytotoxicity. (Biochim Biophys Acta. 2007)

Curcuminoids, curcumin, and demethoxycurcumin reduce lead-induced memory deficits in male wistar rats. (J Agric Food Chem. 2007) "The findings of this study indicate that curcumin, a well-established dietary antioxidant, is capable of playing a major role against heavy metal-induced neurotoxicity and has neuroprotective properties."

Curcumin: the Indian solid gold. (Adv Exp Med Biol. 2007)

Effects of curcumin on retinal oxidative stress and inflammation in diabetes (Nutrition & Metabolism 2007) "Thus, the beneficial effects of curcumin on the metabolic abnormalities postulated to be important in the development of diabetic retinopathy suggest that curcumin could have potential benefits in inhibiting the development of retinopathy in diabetic patients."

Protection from acute and chronic lung diseases by curcumin. (Adv Exp Med Biol. 2007)

Radioprotection and radiosensitization by curcumin. (Adv Exp Med Biol. 2007)

"Spicing Up" of the Immune System by Curcumin. (J Clin Immunol. 2007) "Interestingly, however, curcumin at low doses can also enhance antibody responses. This suggests that curcumin's reported beneficial effects in arthritis, allergy, asthma, atherosclerosis, heart disease, Alzheimer's disease, diabetes, and cancer might be due in part to its ability to modulate the immune system. Together, these findings warrant further consideration of curcumin as a therapy for immune disorders."

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