Gastroesophageal Reflux Disease

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Gastroesophageal Reflux Disease

General Information

NEWS:

ARTICLES:

GERD

JOURNAL ARTICLES:

Association of Body Mass Index With Heartburn, Regurgitation and Esophagitis: Results of the Progression of Gastroesophageal Reflux Disease Study (J Gastroenterol Hepatol. 2007) "Conclusions: In patients with GERD, higher BMI was associated with more severe and more frequent reflux symptoms and esophagitis."

Gastroesophageal Reflux in Patients with Morbid Obesity: A Role of Obstructive Sleep Apnea Syndrome? (Obes Surg. 2008)

GERD-related Erosive Esophagitis and Obesity. (J Clin Gastroenterol. 2008)

Influence of Psychological Distress on Characteristics of Symptoms in Patients with GERD: The Role of IBS Comorbidity. (Dig Dis Sci. 2008)

Mechanisms of heartburn. (Nat Clin Pract Gastroenterol Hepatol. 2008) "Heartburn is a typical symptom of GERD. The spectrum of diseases associated with GERD includes reflux esophagitis, Barrett's esophagus and nonerosive reflux disease (NERD). Although acid reflux is the classic cause of heartburn in patients with erosive esophagitis, the relationship between acid and heartburn is far from clear, especially in patients with NERD. Strong evidence exists that weakly acidic reflux and/or non-acid-related events have a significant role in the generation of heartburn."

Nighttime Heartburn in Patients with Gastroesophageal Reflux Disease under Routine Care. (Digestion. 2008) "Conclusions: The prevalence of nighttime heartburn in GERD patients under routine care was high, even in patients on continuous PPI therapy. Nighttime heartburn was not associated with Barrett's esophagus or most extra-esophageal symptoms."

Noncardiac Chest Pain. (J Clin Gastroenterol. 2008)

Pathophysiology of Gastroesophageal Reflux Disease. (J Clin Gastroenterol. 2008)

Review article: respiratory manifestations of gastro-oesophageal reflux disease (GORD). (Aliment Pharmacol Ther. 2008) "Asthma per se may cause reflux. Patients with difficult-to-treat asthma and/or nocturnal symptoms should be screened for reflux. Reflux can induce chronic cough through different mechanisms including micro-aspiration and both local and central reflexes. Cough and reflux may precipitate each other. A meta-analysis found no significant difference between placebo and Proton pump inhibitors (PPIs) in the resolution of cough. Encouraging results have been reported, following anti-reflux surgery in patients selected on the basis of pH-impedance monitoring. Attention has been drawn to obstructive sleep apnoea syndrome. Conclusions The role of GORD in the pathogenesis of miscellaneous respiratory disorders has been discussed for decades and established in asthma and cough."

Sleep Symptoms and Gastroesophageal Reflux. (J Clin Gastroenterol. 2008) "CONCLUSIONS: Patients with significant nighttime heartburn seem to have more acid reflux compared with those without nighttime heartburn. Nighttime heartburn together with sleep complaints is associated with excessive gastroesophageal reflux."

Systematic review: persistence and severity in gastroesophageal reflux disease. (Aliment Pharmacol Ther. 2008)

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