Bipolar Disorder

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Bipolar Disorder

NIH - Medical Encyclopedia Bipolar disorder

"There are two primary types of bipolar disorder. People with bipolar disorder I have had at least one fully manic episode with periods of major depression. (In the past, bipolar disorder I was called manic depression.) People with bipolar disorder II seldom experience full-fledged mania. Instead they experience periods of hypomania (elevated levels of energy and impulsiveness that are not as extreme as the symptoms of mania). These hypomanic periods alternate with episodes of major depression."

Highlighted Article

Clinical features of bipolar depression versus major depressive disorder in large multicenter trials. (Am J Psychiatry. 2006)

"RESULTS: Bipolar depression was associated with family history of bipolar disorder, an earlier age at onset, a greater previous number of depressive episodes … Fears were more common in patients with bipolar disorder, whereas sadness; insomnia; intellectual (cognitive), somatic (muscular), respiratory, genitourinary complaints; and depressed behavior were more common in patients with unipolar depression."

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Bipolar Disorder

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NEWS:

Largest Study of Its Kind Implicates Gene Abnormalities in Bipolar Disorder: Links Sodium, Calcium Imbalances to Manic Depressive Episodes “The largest genetic analysis of its kind to date for bipolar disorder has implicated machinery involved in the balance of sodium and calcium in brain cells. Researchers supported in part by the National Institute of Mental Health, part of the National Institutes of Health, found an association between the disorder and variation in two genes that make components of channels that manage the flow of the elements into and out of cells, including neurons.”

ARTICLES:

JOURNAL ARTICLES:

The genetics of psychotic bipolar disorder. (Curr Psychiatry Rep. 2008)

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