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Lung Cancer
Treatment is updated with the most recent articles listed on top. REVIEW our Selected Lung Cancer Articles in 2007. Stay informed and updated!
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NIH - Medical Encyclopedia Lung cancer - non-small cell “Non-small cell lung cancer (NSCLC) is the most common type of lung cancer. It usually grows and spreads more slowly than small cell lung cancer. There are three forms of NSCLC: • Adenocarcinomas are often found in an outer area of the lung. • Squamous cell carcinomas are usually found in the center of the lung by an air tube (bronchus). • Large cell carcinomas can occur in any part of the lung. They tend to grow and spread faster than the other two types. Causes - Smoking causes most cases of lung cancer. Being around the smoke from others (secondhand smoke) also raises your risk for lung cancer. However, people who do not smoke and have never smoked have become sick with lung cancer. A review of decades of research has recently shown that smoking marijuana may help cancer cells grow, but there is no direct link between the drug and lung cancer. High levels of air pollution, working with or near cancer-causing chemicals or materials (such as asbestos), and drinking water containing high levels of arsenic can increase your risk for lung cancer. Radiation therapy to the lungs can also increase the risk.” NIH - Medical Encyclopedia Lung cancer - small cell “Small cell lung cancer (SCLC) is a fast-growing type of lung cancer. It tends to spread much more quickly than non-small cell lung cancer. There are three different types of small cell lung cancer: • Small cell carcinoma (oat cell cancer) • Mixed small cell/large cell carcinoma • Combined small cell carcinoma Most small cell lung cancers are the oat cell type. About 15% of all lung cancer cases are small cell lung cancer, according to the American Cancer Society. Small cell lung cancer is a bit more common in men than women. Causes - Smoking almost always causes small cell lung cancer. This type of lung cancer is rare in those who have never smoked. Small cell lung cancer usually starts in the air tubes (bronchi) in the center of the chest. Although the cancer cells are small, they grow quickly and create large masses (tumors) that can rapidly spread to other parts of the body, including the brain, liver, and bone.” Mayo Clinic Lung Cancer "Lung cancer is the leading cause of cancer deaths in the United States, among both men and women. It claims more lives than colon, prostate, lymph and breast cancer combined. Yet most of these lung cancer deaths could have been prevented. That's because smoking accounts for nearly 90 percent of lung cancer cases. … Because lung cancer doesn't cause signs or symptoms in its earliest stages, it's often advanced by the time it's diagnosed. When symptoms do occur, the most common warning sign is a cough, which occurs when a tumor irritates the lining of the airways or blocks the passage of air. In addition to a new cough, be alert for: • "Smoker's cough" that worsens • Coughing up blood, even a small amount • Chest pain • Shortness of breath • New onset of wheezing • Repeated bouts of pneumonia or bronchitis • Hoarseness that lasts more than two weeks Lung cancer also may cause fatigue, loss of appetite and weight loss. If it has spread to other parts of your body (metastasized), you may have headaches or bone pain." NHS - Lung cancer (Video) “Smoking is the most common cause of lung cancer. Around 90% of cases are due to smoking. Other causes include passive smoking and exposure to certain gases and chemicals. Primary and secondary lung cancer This article deals only with primary lung cancer. Primary lung cancer is cancer that originates in the lungs. Secondary lung cancer is cancer which starts in another part of the body and then spreads to the lungs. Types of primary lung cancer There are two main types of primary lung cancer - small cell lung cancer and non-small cell lung cancer. Around 80% of cases are non-small cell lung cancer. Non-small cell lung cancer includes three types: • squamous cell carcinoma, • adenocarcinoma, and • large cell carcinoma. Small cell and non-small cell lung cancers are treated in different ways. Therefore, it is very important that you have a number of tests, so that the exact type of cancer can be diagnosed. Around 10% of people with lung cancer will be cured (live for five years without the cancer returning). There are many treatments available which can reduce the effects of lung cancer, and slow down its progress, therefore improving your quality of life. “ Highlighted Articles
Non-small cell lung cancer: epidemiology, risk factors, treatment, and survivorship. (Mayo Clin Proc. 2008) “Non-small cell lung cancer accounts for 85% of all lung cancer cases in the United States. After the initial diagnosis, accurate staging of non-small cell lung cancer using computed tomography or positron emission tomography is crucial for determining appropriate therapy. When feasible, surgical resection remains the single most consistent and successful option for cure. However, close to 70% of patients with lung cancer present with locally advanced or metastatic disease at the time of diagnosis. Chemotherapy is beneficial for patients with metastatic disease, and the administration of concurrent chemotherapy and radiation is indicated for stage III lung cancer.” Fruits, Vegetables And Teas May Protect Smokers From Lung Cancer, Researchers Report (2008) “UCLA researchers found that smokers who ingested high levels of natural chemicals called flavonoids in their diet had a lower risk of developing lung cancer, an important finding since more than 90 percent of lung cancers are caused by tobacco smoking.“ CancerHelp UK - Types of lung cancer "There are important differences between lung cancer that started in the lungs and lung cancer that has spread to the lung from another part of the body. … Primary lung cancer (cancer that has started in the lungs) "There are several different types of primary lung cancer. These are divided into two main types • Small cell lung cancer • Non-small cell lung cancer ... Secondary lung cancer (cancer that has spread to the lungs) Secondary cancer is cancer that has spread from somewhere else in the body. There are quite a few different cancers that can spread to the lungs, including breast cancer and bowel cancer" Knee Pain May Signal Lung Cancer (2007)"Heavy smokers with knee arthritis may be experiencing an early sign of a difficult-to-treat lung cancer, research shows. … About 85 percent of all lung cancers are non-small cell lung cancer, according to the American Cancer Society. Unless it is caught early, non-small cell lung cancer is difficult to treat. It spreads to the bones in one in five cases and is well advanced by the time it is diagnosed in half of all cases." [The epidemiology of lung cancer.] (Pneumonol Alergol Pol. 2007) "Worldwide, lung cancer is the most common cause of cancer mortality in males and females. In the Europe lung cancer accounts for 21% of all cancer cases in males and 29% of all cancer deaths." Highlighted Internet SitesCONTINUE YOUR INFOMEDSEARCH RESEARCH with our previous InfoMedLinks. Start with InfoMedLinks 2007.
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Lung CancerGeneralNEWS:Cigarette Company Paid for Lung Cancer Study “In October 2006, Dr. Claudia Henschke of Weill Cornell Medical College jolted the cancer world with a study saying that 80 percent of lung cancer deaths could be prevented through widespread use of CT scans. Small print at the end of the study, published in The New England Journal of Medicine, noted that it had been financed in part by a little-known charity called the Foundation for Lung Cancer: Early Detection, Prevention & Treatment. A review of tax records by The New York Times shows that the foundation was underwritten almost entirely by $3.6 million in grants from the parent company of the Liggett Group, maker of Liggett Select, Eve, Grand Prix, Quest and Pyramid cigarette brands. The foundation got four grants from the Vector Group, Liggett’s parent, from 2000 to 2003. “ Half of Cancer Patients Survive “One in three men and one in four women get cancer throughout their lives and half of them overcome the disease, according to cancer statistics for 2003 to 2005 and the five-year survival rate of cancer patients released on Wednesday by the Korea Central Cancer Registry under the Ministry for Health, Welfare and Family Affairs.” Tumor Size Important Indicator for Survival in Lung Cancer “Among patients with resected non–small-cell lung carcinoma (NSCLC), tumors over 15 mm in diameter are associated with an increased risk for mediastinal metastases and with shorter 5-year survival. This was found to be the case in all tumor, node, and metastasis (TNM) system categories, researchers report in the September issue of the Journal of Thoracic Oncology.” ARTICLES:JOURNAL ARTICLES:A Japanese Lung Cancer Registry study: prognosis of 13,010 resected lung cancers. (J Thorac Oncol. 2008) Age and comorbidity as independent prognostic factors in the treatment of non small-cell lung cancer: a review of national cancer institute of Canada clinical trials group trials. (J Clin Oncol. 2008) “CONCLUSION In these large, randomized trials, the presence of comorbid conditions (CCIS >/= 1), rather than age more than 65 years, was associated with poorer survival.” Age-related Effects of Smoking on Lung Cancer Mortality: A Nationwide Case-Control Comparison in 103 Population Centers in China. (Ann Epidemiol. 2008) Differences in outcomes between younger and older patients with non-small cell lung cancer. (Ann Thorac Surg. 2008) “CONCLUSIONS: Despite similar stages and tumor characteristics patients younger than 45 years of age with non-small cell lung cancer have a significantly worse prognosis than older patients. Although they are more likely to be symptomatic, younger patients have a greater delay in seeking thoracic surgical care. These data should be considered in the treatment strategy offered to younger patients with non-small cell lung cancer.” Disease control rate at 8 weeks predicts clinical benefit in advanced non-small-cell lung cancer: results from Southwest Oncology Group randomized trials. (J Clin Oncol. 2008) Inflammation and lung cancer: roles of reactive oxygen/nitrogen species. (J Toxicol Environ Health B Crit Rev. 2008) “During inflammation, enhanced ROS/RNS production may induce recurring DNA damage, inhibition of apoptosis, and activation of proto-oncogenes by initiating signal transduction pathways. Therefore, it is conceivable that chronic inflammation-induced production of ROS/RNS in the lung may predispose individuals to lung cancer. This review describes the complex relationship between lung inflammation and carcinogenesis, and highlights the role of ROS/RNS in cancer development.” Non-small cell lung cancer and silent brain metastasis Survival and prognostic factors. (Lung Cancer. 2008) Non-small cell lung cancer: epidemiology, risk factors, treatment, and survivorship. (Mayo Clin Proc. 2008) “Non-small cell lung cancer accounts for 85% of all lung cancer cases in the United States. After the initial diagnosis, accurate staging of non-small cell lung cancer using computed tomography or positron emission tomography is crucial for determining appropriate therapy. When feasible, surgical resection remains the single most consistent and successful option for cure. However, close to 70% of patients with lung cancer present with locally advanced or metastatic disease at the time of diagnosis. Chemotherapy is beneficial for patients with metastatic disease, and the administration of concurrent chemotherapy and radiation is indicated for stage III lung cancer.” Predicting Survival in Potentially Curable Lung Cancer Patients. (Lung. 2008) Small cell lung cancer. (Mayo Clin Proc. 2008) “Small cell lung cancer accounts for approximately 15% of bronchogenic carcinomas. It is the cancer most commonly associated with various paraneoplastic syndromes, including the syndrome of inappropriate antidiuretic hormone secretion, paraneoplastic cerebellar degeneration, and Lambert-Eaton myasthenic syndrome. Because of the high propensity of small cell lung cancer to metastasize early, surgery has a limited role as primary therapy. Although the disease is highly sensitive to chemotherapy and radiation, cure is difficult to achieve. The combination of platinum and etoposide is the accepted standard chemotherapeutic regimen. It is also the accepted standard therapy in combination with thoracic radiotherapy (TRT) for limited-stage disease. Adding TRT increases absolute survival by approximately 5% over chemotherapy alone.” The impact of cigarette smoking on prognosis in small adenocarcinomas of the lung: the association between histologic subtype and smoking status. (J Thorac Oncol. 2008) “CONCLUSIONS: When adenocarcinomas were small (diameter =2 cm) cigarette smoking and male gender were associated with Non or min BAC histologic subtypes, which are thought to have more aggressive biologic features resulting in poorer outcome compared with other subtypes.”
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