Prostate Cancer
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Prostate Cancer
NHS - Prostate cancer “Diagnosing prostate cancer Prostate-specific antigen (PSA) testing The main test for prostate cancer is the PSA (prostate-specific antigen) test, which looks for raised levels of PSA in the blood. Prostate cancer increases the production of PSA, so the test may be able to detect prostate cancer in its early stages. However, the test is problematic: • Up to 20% of men who do have prostate cancer will not have a raised PSA level; • Over 65% of men with a raised PSA level will not have cancer. PSA levels tend to rise in all men as they get older. Digital rectal examination The next step to confirming a diagnosis of prostate cancer is a digital rectal examination (DRE). This can be done by your GP. During a DRE, your GP will insert a finger into your rectum (back passage). The rectum is close to your prostate gland, so your GP is able to check to see if the surface of the gland has changed. This will feel a little uncomfortable but it should not cause you pain. Prostate cancer can cause the gland to become hard and bumpy. However, in some cases, the cancer causes no changes to the gland and a DRE may not be able to detect the cancer. DRE is also useful in ruling out benign prostatic hyperplasia, as this causes the gland to feel firm and smooth. Biopsy Your GP will assess the risk of you possibly having prostate cancer based on a number of factors, including your PSA levels, the results of your DRE and associated risk factors such as age, family history and ethnic group. If it is felt that the risk is significant you will be referred to a hospital to discuss the options of further tests. The most commonly used test is known as a transrectal ultrasound-guided biopsy (TRUS). During a TRUS biopsy, an ultrasound scanner (a machine that uses sound waves to build up a picture of the inside of your body) is used to study your prostate. This also allows the doctor to guide a needle through your rectum which is then used to take small samples of tissue from your prostate (biopsy). The procedure can be uncomfortable and sometimes painful. You may be given a local anaesthetic to minimize any discomfort. The biopsy may also cause complications such as bleeding and infection. Although it is much more reliable than a PSA test, a biopsy may miss up to 20% of cancers. Therefore, you may need to undergo another biopsy if your symptoms persist, or your PSA level continues to rise. Gleason score The samples of tissue from the biopsy are then studied in a laboratory. If cancerous cells are found, they can be studied further to see how quickly the cancer will spread. This is done by giving the samples a grade, known as a Gleason score. The lower the score, the less likely the cancer will spread. • a Gleason score of 6 or less means the cancer is unlikely to spread, • a Gleason score of 7 means that there is a moderate chance of the cancer spreading, and • a Gleason score of 8 or above means that there is a significant chance that the cancer will spread. Further testing If it is felt that there is a significant chance that the cancer has spread from your prostate to other parts of the body, further tests may be recommended. Two tests that are commonly used are: • A magnetic resonance imaging (MRI ) scan - which uses magnetic waves to build up a detailed picture of the inside of your body. A MRI scan can tell if the cancer has spread beyond the prostate to the surrounding tissue. • An isotope bone scan - this test uses radiation to detect any abnormalities in your bones. An isotope bone scan can tell if the cancer has spread to your bones. “
NIH - Prostate cancer (Medical Encyclopedia) "The cause of prostate cancer is unknown, although some studies have shown a relationship between high dietary fat intake and increased testosterone levels. … Prostate cancer is the third most common cause of death from cancer in men of all ages and is the most common cause of death from cancer in men over 75 years old. Prostate cancer is rarely found in men younger than 40. … Men at higher risk include black men older than 60, farmers, tire plant workers, painters, and men exposed to cadmium. The lowest incidence occurs in Japanese men and vegetarians. Prostate cancers are classified or staged based on their aggressiveness and how different they are from the surrounding prostate tissue. There are several different ways to stage tumors, a common one being the A-B-C-D staging system, also known as the Whitmore-Jewett system: A: Tumor is not palpable (not felt on physical examination), and is usually detected by accident after prostate surgery done for other reasons. B: Tumor is confined to the prostate and usually detected by physical examination or PSA testing. C: Tumor extends beyond the prostate capsule without spread to lymph nodes. D: Cancer has spread (metastasized) to regional lymph nodes or other parts of the body (bone and lungs, for example)
Highlighted Articles
Doctors Urged Not to Screen Elderly Men for Prostate Cancer (2008) “In a move that could lead to significant changes in medical care for older men, a national task force on Monday recommended that doctors stop screening men ages 75 and older for prostate cancer because the search for the disease in this group is causing more harm than good.”
Body Mass Index, Weight Change, and Risk of Prostate Cancer in the Cancer Prevention Study II Nutrition Cohort (Cancer Epidemiology Biomarkers & Prevention 2007) "Conclusion: Obesity increases the risk of more aggressive prostate cancer and may decrease either the occurrence or the likelihood of diagnosis of less-aggressive tumors. Men who lose weight may reduce their risk of prostate cancer."
Meat Consumption among Black and White Men and Risk of Prostate Cancer in the Cancer Prevention Study II Nutrition Cohort (Cancer Epidemiol Biomarkers Prev 2006) "No measure of meat consumption was associated with risk of prostate cancer among White men. Among Black men, total red meat intake (processed plus unprocessed red meat) was associated with higher risk of prostate cancer … this increase in risk was mainly due to risk associated with consumption of cooked processed meats (sausages, bacon, and hot dogs … This study suggests that high consumption of cooked processed meats may contribute to prostate cancer risk among Black men in the United States."
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Prostate Cancer
Risk Reduction
NEWS:
Broccoli nudges genes to fight prostate cancer “Just a few more portions of broccoli each week may protect men from prostate cancer, British researchers reported on Wednesday. The researchers believe a chemical in the food sparks hundreds of genetic changes, activating some genes that fight cancer and switching off others that fuel tumors, said Richard Mithen, a biologist at Britain's Institute of Food Research.”
Certain form of tomatoes could be key to prostate cancer prevention ““It appears that the greatest protective effect from tomatoes comes from rehydrating tomato powder into tomato paste,” said Valeri Mossine, research assistant professor of biochemistry in the College of Agriculture, Food and Natural Resources. “Processing of many edible plants through heating, grinding, mixing or drying dramatically increases their nutritional value and cancer-fighting potential.” “
Men Who Are Continually Active At Work May Have Decreased Prostate Cancer Risk, Study Suggests “The study found that the men who developed prostate cancer were less likely to hold the more physically active jobs. Those that got cancer also were more likely than the control group to be highly exposed to the chemicals that were evaluated, including hydrazine, benzene, mineral oil, polycyclic aromatic hydrocarbons (PAHs) and trichloroethylene (TCE), which are known or suspected carcinogens. The findings are supported by other studies that suggest continuous physical activity, but not intermittent activity, is required to lower the risk of prostate cancer.“
Prostate cancer prevention: What you can do
Reducing Intake Of Dietary Fat Prevents Prostate Cancer In Mice “"A low-fat, high-fiber diet combined with weight loss and exercise is well known to be healthy in terms of heart disease and is known to reduce the risk of heart attacks and strokes, so that would be a healthy choice to make," Aronson said. "Whether or not it will prevent prostate cancer in humans remains to be seen." “
ARTICLES:
JOURNAL ARTICLES:
Dietary intake of vitamin K and risk of prostate cancer in the Heidelberg cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC-Heidelberg) (Am J Clin Nutr 2008) “Conclusions:Our results suggest an inverse association between the intake of menaquinones, but not that of phylloquinone, and prostate cancer. Further studies of dietary vitamin K and prostate cancer are warranted. “
[Fish intake and the risk of prostate cancer in Japan: a prospective cohort study] (Nippon Hinyokika Gakkai Zasshi. 2008)
Flaxseed Supplementation (Not Dietary Fat Restriction) Reduces Prostate Cancer Proliferation Rates in Men Presurgery (Cancer Epidemiology Biomarkers & Prevention 2008) Conclusions: Findings suggest that flaxseed is safe and associated with biological alterations that may be protective for prostate cancer. Data also further support low-fat diets to manage serum cholesterol”
New Take on a Prostate Drug, and a New Debate “Prostate cancer is unlike any other because it is relatively slow-growing and while it can kill, it often is not lethal. In fact, most leading specialists say, a major problem is that men are getting screened, discovering they have cancers that may or may not be dangerous, and opting for treatments that can leave them impotent or incontinent. So should healthy men take a drug for the rest of their lives to avoid getting and being treated for a cancer that, most often, would be better off undiscovered and untreated? Is it worth risking a chance that unanticipated side effects may emerge years later if millions of men with no prostate problems take the drug? “
The effect of walnut intake on factors related to prostate and vascular health in older men. (Nutr J. 2008) “The significant decrease in the alpha-tocopherol: gamma-tocopherol ratio with an increase in serum gamma-tocopherol and a trend towards an increase in the ratio of free PSA:total PSA following the 8-week supplement study suggest that walnuts may improve biomarkers of prostate and vascular status.”
Vitamin D protects cells from stress that can lead to cancer “By inducing a specific gene to increase expression of a key enzyme, vitamin D protects healthy prostate cells from the damage and injuries that can lead to cancer, University of Rochester Medical Center researchers report.”
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