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Supplements - Nutrition
Selenium
NEWS:
Selenium May Protect Against Bladder Cancer
Selenium Supplements May Not Be Needed, Study Suggests “Interestingly, only 20% of lower organisms use selenium-based proteins, and, for example, fungi and vascular plants do not. Some insects have also lost the need for selenium during the course of evolution. Aquatic environments seem to favor an increased reliance on selenium because of environmental factors. Selenoprotein-rich Sea urchins, for instance, feed on algae, which themselves contain a lot of selenium. Gladyshev concludes: "The evolved reduced utilization of selenium-containing proteins in mammals raises important questions in human and animal nutrition. Selenoprotein expression is regulated such that people don't need to rely so heavily on dietary selenium which is often present in excess amounts in the diet. Individuals should consider their age, sex and medical needs before taking such supplements on a regular basis." Selenium is a trace element used in proteins, in the form of the twenty-first naturally occurring amino acid (selenocysteine).“
Selenium to Prevent Recurrence of Colorectal Polyps
ARTICLES:
Selenium Toxicity: A Case of Selenosis Caused by a Nutritional Supplement
JOURNAL ARTICLES:
Food-chain selenium and human health: emphasis on intake. (Br J Nutr. 2008)
Food-chain selenium and human health: spotlight on speciation (Br J Nutr. 2008)
Selenium in food and the human body: A review. (Sci Total Environ. 2008) “Although Se potential as an antioxidant for the prevention of cardiovascular diseases (CVD) is promising, additional long-term intervention trials are necessary. As a result, indiscriminate Se supplements cannot be reliably recommended for the prevention of CVD in human beings. Some interesting findings reported an association of Se intake with a reduced prevalence and risk for prostate and colon cancer. However, random trials for other cancer types are inconclusive. As a final conclusion, the general population should be warned against the employment of Se supplements for prevention of hepatopathies, cardiovascular or cancer diseases, because benefits of Se supplementation are still uncertain, and their indiscriminate use could generate an increased risk of Se toxicity.”
Serum Selenium Levels and All-Cause, Cancer, and Cardiovascular Mortality Among US Adults (Arch Intern Med. 2008) “Conclusions In a representative sample of the US population, we found a nonlinear association between serum selenium levels and all-cause and cancer mortality. Increasing serum selenium levels were associated with decreased mortality up to 130 ng/mL. Our study, however, raises the concern that higher serum selenium levels may be associated with increased mortality.”
Supplementation of healthy volunteers with nutritionally relevant amounts of selenium increases the expression of lymphocyte protein biosynthesis genes (American Journal of Clinical Nutrition 2008) “Background: Selenium is incorporated into 25 selenoproteins in humans. Low dietary selenium has deleterious effects on health and may result in cancer, cardiovascular disease, and immune dysfunction. The underlying mechanisms are not fully understood. Lymphocytes are a target tissue; they can be assessed in healthy persons, and their response has not been explored by using global gene expression profiling techniques. … Conclusions: Ribosomal protein and translation factor genes were up-regulated in response to increased selenium intake. We hypothesize that this up-regulation is linked to increased selenoprotein production and enhanced lymphocyte function.”
The role of selenium in chronic disease. (Nutr Clin Pract. 2008)
INTERNET SITES:
NIH - Medical Encyclopedia Selenium in diet
NIH - Medical Encyclopedia - Selenium - antioxidant
NIH - Selenium Sulfide (Topical)
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