Gastroesophageal Reflux Disease
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Gastroesophageal Reflux Disease
Daily Treatment Report
Cognitive Therapy-CBT-Psychotherapy
Device Therapy
Drug Side-Effects and Interactions
How Safe Are Popular Reflux Drugs? The drugs belong to a class of pharmaceuticals called "proton pump inhibitors," or PPIs, which are generally considered safe and effective. But lately these acid-reducing medications have been the subject of studies linking their use to a number of health risks, from an increased rate of hip fracture to a greater likelihood of diarrhea and community-acquired pneumonia. … Altman said he is mostly concerned about high-dose and long-term users of the drugs because their increased exposures boost the odds that they'll experience some unintended consequence. He's also worried about people who continue to use PPIs but don't get better. "They may not have acid reflux, or they may already have a more severe complication of acid reflux than they're aware of," he said. Patients who have concerns about the use of these drugs should speak with their physicians, Vaezi said. But he also said that people need to recognize that the findings of these studies merely suggest an association with a particular outcome -- not a cause.”
Long-term treatment with proton pump inhibitor is associated with undesired weight gain. (World J Gastroenterol. 2009)
Proton Pump Inhibitors to Treat GERD Cause Heartburn Problems
Proton-Pump Inhibitor Withdrawal May Cause Rebound Acid Hypersecretion “Proton-pump inhibitor (PPI) therapy for 8 weeks induces acid-related symptoms in healthy volunteers after withdrawal, according to the results of a randomized, double-blind, placebo-controlled trial reported in the July issue of Gastroenterology. "Rebound acid hypersecretion (RAHS) has been demonstrated after 8 weeks of treatment with a proton-pump inhibitor (PPI)," write Christina Reimer, from Køge University Hospital, Copenhagen University in Copenhagen, Denmark, and colleagues. "If RAHS induces acid-related symptoms, this might lead to PPI dependency and thus have important implications." “
Acid-Suppressive Medication Use and the Risk for Hospital-Acquired Pneumonia (JAMA 2009) “Conclusions In this large, hospital-based pharmacoepidemiologic cohort, acid-suppressive medication use was associated with 30% increased odds of hospital-acquired pneumonia. In subset analyses, statistically significant risk was demonstrated only for proton-pump inhibitor use.”
Boxed warning about tardive dyskinesia added to metoclopramide label “Metoclopramide is approved for the short-term treatment of gastroesophageal reflux disease (GERD) in patients who have not responded to other treatments and for the treatment of diabetic gastroparesis. This agent is available in tablet, oral solution, and injection formulations.”
Drugs
Exercise
General Information
Gastroesophageal Reflux Disease: Treatment & Medication
Study compares 2 nonsurgical treatments for reflux disease ""Our experience indicates that radiofrequency and full-thickness plication are both effective, providing symptomatic relief and reduction in proton pump inhibitor use," the authors conclude. "For patients whose chief complaint is regurgitation, full-thickness plication may be the preferred procedure. Further study is needed to determine the long-term effectiveness of endoluminal treatments.""
Guidelines
Immunotherapy
Internet Sites
Treatment Information
Drug-Food-Supplement Information
DrugDigest (drug interactions)
FDA - Drug Interactions: What You Should Know
NIH - Botanical Dietary Supplements: Background Information
NIH - Drug, Supplements, and Herbal Information
NIH - Herbal Supplements: Consider Safety, Too
NIH - Vitamin and Mineral Supplement Fact Sheets
Nutrition
Other
Other Treatments
Experimental
Radiotherapy
Supplements-Vitamins-CAM
Surgery
Gastro-oesophageal reflux disease and non-asthma lung disease (EUROPEAN RESPIRATORY REVIEW, 2009) “Laparoscopic fundoplication is the procedure of choice for medically refractory GERD with excellent short-term results with respect to respiratory symptoms associated with GERD; however, long-term studies document a significant percentage of patients requiring ongoing acid suppression therapy.”
Transplantation
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