Bipolar Disorder

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Bipolar Disorder

NIH - Medical Encyclopedia Bipolar disorder

"There are two primary types of bipolar disorder. People with bipolar disorder I have had at least one fully manic episode with periods of major depression. (In the past, bipolar disorder I was called manic depression.) People with bipolar disorder II seldom experience full-fledged mania. Instead they experience periods of hypomania (elevated levels of energy and impulsiveness that are not as extreme as the symptoms of mania). These hypomanic periods alternate with episodes of major depression."

Highlighted Article

Clinical features of bipolar depression versus major depressive disorder in large multicenter trials. (Am J Psychiatry. 2006)

"RESULTS: Bipolar depression was associated with family history of bipolar disorder, an earlier age at onset, a greater previous number of depressive episodes … Fears were more common in patients with bipolar disorder, whereas sadness; insomnia; intellectual (cognitive), somatic (muscular), respiratory, genitourinary complaints; and depressed behavior were more common in patients with unipolar depression."

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Bipolar Disorder

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Bipolar Disorder

JOURNAL ARTICLES:

Bipolar disorder and aggression. (Int J Clin Pract. 2009)

Bipolar disorder as a risk factor for repeat DUI behavior. (J Affect Disord. 2009)

Cigarette smoking is associated with suicidality in bipolar disorder. (Bipolar Disord. 2009)

Cognitive impairment in early and late bipolar disorder. (Am J Geriatr Psychiatry. 2009) “CONCLUSIONS: Older patients with bipolar disorder have substantial cognitive impairments. Late onset bipolar disorder is associated with more severe cognitive impairment than early-onset bipolar disorder. For clinical practice, it is important to develop treatment strategies which take this into account.”

Comorbidity in pediatric bipolar disorder. (Child Adolesc Psychiatr Clin N Am. 2009) “The growing literature shows the pervasiveness and importance of comorbidity in youth with bipolar disorder (BPD). For instance, up to 90% of youth with BPD have been described to manifest comorbidity with attention-deficit hyperactivity disorder. Multiple anxiety, substance use, and disruptive behavior disorders are the other most commonly reported comorbidities with BPD. Moreover, important recent data highlight the importance of obsessive-compulsive and pervasive developmental illness in the context of BPD. Data suggest that not only special developmental relationships are operant in the context of comorbidity but also that the presence of comorbid disorders with BPD results in a more severe clinical condition.”

Early stages in the development of bipolar disorder. (J Affect Disord. 2009)

Facial emotion recognition in bipolar disorder: a critical review. (Rev Bras Psiquiatr. 2009)

High prevalence of metabolic disturbances in patients with bipolar disorder in Taiwan. (J Affect Disord. 2009)

How common are psychotic and bipolar disorders? A 50-year follow-up of the Lundby population. (Nord J Psychiatry. 2009)

Increased oxidative stress in the anterior cingulate cortex of subjects with bipolar disorder and schizophrenia (Bipolar Disorders 2009) “Conclusions: Oxidative damage in the brain may contribute in part to the pathological process in BD and schizophrenia. This finding also suggests antioxidative stress as a probable alternative approach to the pharmacological treatment of these psychiatric disorders.”

Lifetime psychiatric disorders in school-aged offspring of parents with bipolar disorder: the Pittsburgh Bipolar Offspring study. (Arch Gen Psychiatry. 2009) “CONCLUSIONS: Offspring of parents with BP are at high risk for psychiatric disorders and specifically for early-onset BP spectrum disorders. These findings further support the familiality and validity of BP in youth and indicate a need for early identification and treatment.”

Polarity at illness onset in bipolar I disorder and clinical course of illness. (Bipolar Disord. 2009)

The longitudinal course of cognition in older adults with bipolar disorder. (Bipolar Disord. 2009)

Tobacco smoking behaviors in bipolar disorder: a comparison of the general population, schizophrenia, and major depression. (Bipolar Disord. 2009)

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