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Aging - Anti-Aging

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REVIEW our Selected Aging Articles in 2009. Stay informed and updated!

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InfoMedSearch: Aging and Anti-Aging

PREVENT: FALLS, NUTRITIONAL DEFICIENCIES, DEHYDRATION, HEAT STROKE

PROMOTE: MENTAL AND PHYSICAL ACTIVITY

Falls

NIH - Falls “A fall can change your life. If you're elderly, it can lead to disability and a loss of independence. If your bones are fragile from osteoporosis, you could break a bone, often a hip. But aging alone doesn't make people fall. Diabetes and heart disease affect balance. So do problems with circulation, thyroid or nervous systems. Some medicines make people dizzy. Eye problems or alcohol can be factors. Any of these things can make a fall more likely. … Falls and accidents seldom "just happen." Taking care of your health by exercising and getting regular eye exams and physicals may help reduce your chance of falling. Getting rid of tripping hazards in your home and wearing nonskid shoes may also help. To reduce the chances of breaking a bone if you do fall, make sure that you get enough calcium and vitamin D. “

NIH - Falls and Fractures

NIH - Falls and Older Adults “More than one in three people age 65 years or older falls each year. The risk of falling -- and fall-related problems -- rises with age.”

Highlighted Articles

The functional effects of physical exercise training in frail older people : a systematic review. (Sports Med. 2008) “This systematic review suggests that older adults with different levels of abilities can improve their functional performance by regular exercise training.”

Astronaut Technology Could Prevent Elderly Falls “The National Osteoporosis Foundation estimates 300,000 people annually suffer hip fractures, which are often caused by falls. An average of 24 percent of hip fracture patients age 50 and over die within a year of the fracture. Many fall victims who don't die within a year end up being disabled the rest of their lives. "It's a huge issue," said Elinor Ginzler of the AARP. "It significantly impairs your ability to stay independent, which is what people want." “

Brain injuries from falls a deadly risk for seniors “Arias said that as the numerous baby boom generation hits retirement age, more people will fall and either die or require expensive hospital care. "CDC has developed tips and suggestions for older adults, their caregivers, health care providers, and communities to help prevent falls," Arias said. These include reducing floor clutter and providing better lighting as well as regular exercise to maintain strength and balance. More information is available at http://www.cdc.gov/ncipc/preventingfalls/.“

A typology of oral hydration problems exhibited by frail nursing home residents. (J Gerontol Nurs. 2006) "Dehydration remains a substantial problem for nursing home residents, often with poor health outcomes. … Dehydration events occurred in 31% (11 of 35) of residents during the 6-month period."

Strategies for ensuring good hydration in the elderly. (Nutr Rev. 2005) "Dehydration is a frequent etiology of morbidity and mortality in elderly people. It causes the hospitalization of many patients and its outcome may be fatal. Indeed, dehydration is often linked to infection, and if it is overlooked, mortality may be over 50%. Older individuals have been shown to have a higher risk of developing dehydration than younger adults. Modifications in water metabolism with aging and fluid imbalance in the frail elderly are the main factors to consider in the prevention of dehydration. Particularly, a decrease in the fat free mass, which is hydrated and contains 73% water, is observed in the elderly due to losses in muscular mass, total body water, and bone mass. Since water intake is mainly stimulated by thirst, and since the thirst sensation decreases with aging, risk factors for dehydration are those that lead to a loss of autonomy or a loss of cognitive function that limit the access to beverages."

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Notes

The Guidelines section will contain the 2006 and certain 2005 updated published guidelines. To view Guidelines from previous years, view year 2005 InfoMedlinks (Articles section) or our Monthly Online Newsletter (under the Guidelines section).

Aging - Anti-Aging

Daily Treatment Report

Cognitive Therapy-CBT-Psychotherapy

 

Device Therapy

 

Drug Side-Effects and Interactions

Adverse Events Associated with Testosterone Administration (NEJM 2010)

Drugs

Testosterone and the aging male: To treat or n ot to treat? (Maturitas. 2010)

Donepezil Treatment and Changes in Hippocampal Structure in Very Mild Alzheimer Disease (Arch Neurol. 2010) “Conclusions Treatment with donepezil did not alter the progression of hippocampal deformation in subjects with DAT in this study. Small sample size may have contributed to this outcome.”

Exercise

Is physical rehabilitation for older people in long-term care effective? Findings from a systematic review (Age and Ageing 2010) “Conclusion: physical rehabilitation for older people in long-term care is acceptable and potentially effective.”

General Information

Guidelines

Immunotherapy

 

Internet Sites

Treatment Information

DrugBank (drug structure)

FDA - MedWatch (Drug Alerts)

Drug-Food-Supplement Information

Drug Information Online

Drug Interaction Checker

DrugDigest (drug interactions)

FDA - Drug Interactions: What You Should Know

NIH - Botanical Dietary Supplements: Background Information

NIH - Drug, Supplements, and Herbal Information

NIH - Herbal Supplements: Consider Safety, Too

NIH - Medicines

NIH - Vitamin and Mineral Supplement Fact Sheets

Nutrition

 

Other

Other Treatments

Experimental

Supplements-Vitamins-CAM

Effect of Folic Acid, with or without Other B Vitamins, on Cognitive Decline: Meta-Analysis of Randomized Trials (American Journal of Medicine 2010) “Randomized trials show no effect of folic acid, with or without other B vitamins, on cognitive function within 3 years of the start of treatment. Trials of longer duration, recording the incidence of dementia, as well as cognitive decline, are needed.”

Annual High-Dose Oral Vitamin D and Falls and Fractures in Older Women (JAMA. 2010) “Meta-analyses suggest that there is a threshold level for vitamin D supplementation of more than 400 IU daily for fracture risk reduction and that reductions in hip and nonvertebral fractures are independent of calcium supplementation.14-18 Doses of 700 to 800 IU daily reduced the risk of nonvertebral and hip fractures with stronger evidence of benefit in reducing hip fracture risk when the analysis was restricted to institutionalized adults.18 By contrast, a Cochrane review20 concluded that vitamin D therapy alone appeared unlikely to be effective in preventing fracture. Evidence of risk reduction of falls with vitamin D supplementation with and without calcium is also inconsistent. Overall there appears to be an 11% to 19% reduction in fall risk with supplementation and a possible dose threshold of 700 to 1000 IU daily.18, 23 No fall risk reduction was observed for doses of less than 700 IU or achieved serum 25-hydroxycholecalciferol levels of less than 60 nmol/L, consistent with an earlier review of trials using varying doses of vitamin D that concluded that there was insufficient evidence that cholecalciferol treatment reduced falls.36 Currently 600 IU (15 µg) per day is recommended for adults 70 years or older in the United States and Canada37-38 with an upper limit of 2000 IU per day (~ 700 000 IU per year). Cholecalciferol 1000 IU is listed on the Australian Register of therapeutic goods. Although our results cannot necessarily be applied to high-dose vitamin D administered in divided doses over the year, they suggest that further study to assess safety is needed.”

Weekly Vitamin D3 Improves Vitamin D Insufficiency but Not Neuromuscular Function in Older Adults

Surgery

Frail Patients Are at Increased Risk for Mortality and Prolonged Institutional Care After Cardiac Surgery. (Circulation. 2010)

Transplantation

 

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