Asthma

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Asthma

General Information

NEWS:

Acetaminophen: Teen Asthma Trigger?

Chronic Nasal Congestion May Be Linked to Severe Asthma

High-fat meals a no-no for asthma patients “Subjects who had consumed the high-fat meal had a marked increase in airway neutrophils and TLR4 mRNA gene expression. TLR4 is a cell surface receptor that is activated by nutritional fatty acids: TLR4 'senses' the presence of saturated fatty acids, and prompts the cell to respond to the fatty acids as if they were an invading pathogen, releasing inflammatory mediators. While the study didn't definitively distinguish between high fat and high energy, this increase in TLR4 activity suggests that dietary fat is important to the effects. Subjects who had consumed the high fat meal also had reduced bronchodilator response as measured by FEV1% predicted and FEV1/FVC%, when compared to those had consumed the low-fat meal.”

Insufficient vitamin D tied to severe asthma attacks “The effects of vitamin D on the immune system, which include the inflammatory response to infections, might help explain why higher levels of the vitamin were linked to a lower risk of severe asthma exacerbations, according to Litongua's team. They say it's also possible that vitamin D enhances the effects of anti-inflammatory steroid hormones -- both the body's natural supply and the synthetic corticosteroids used to treat asthma. In this study, the beneficial association between vitamin D and asthma attacks was mainly seen in children who were on budesonide, a corticosteroid. The American Academy of Pediatrics recommends that infants, children and teenagers get 400 IU of vitamin D each day. Milk, breakfast cereals and orange juice fortified with the vitamin are the main food sources, though some fatty fish naturally contain high amounts of vitamin D. Experts recommend vitamin pills for children who do not get enough of the vitamin from food.”

Mold May Trigger Severe Asthma in Some Folks “Living in a home with high levels of mold may increase the risk of severe asthma attacks in people with certain gene variants, finds a new study.”

People With Asthma More Likely to Be Depressed “People with asthma are more than twice as likely to have depression or anxiety as people who don't have the chronic airway disease, according to a report in the March issue of the journal Chest.”

ARTICLES:

Slideshow: A Visual Guide to Asthma

JOURNAL ARTICLES:

Predictors of remitting, periodic, and persistent childhood asthma. (J Allergy Clin Immunol. 2010)

What Is the Lifetime Risk of Physician-diagnosed Asthma in Ontario, Canada? (American Journal of Respiratory and Critical Care Medicine 2010) “Conclusions: Our estimated overall lifetime risk indicates that one of every three individuals in Ontario, Canada has physician-diagnosed asthma during one's lifetime.”

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