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Lung Cancer

 

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Lung Cancer

NIH - Medical Encyclopedia Lung cancer - non-small cell “Non-small cell lung cancer (NSCLC) is the most common type of lung cancer. It usually grows and spreads more slowly than small cell lung cancer. There are three forms of NSCLC: • Adenocarcinomas are often found in an outer area of the lung. • Squamous cell carcinomas are usually found in the center of the lung by an air tube (bronchus). • Large cell carcinomas can occur in any part of the lung. They tend to grow and spread faster than the other two types. Causes - Smoking causes most cases of lung cancer. Being around the smoke from others (secondhand smoke) also raises your risk for lung cancer. However, people who do not smoke and have never smoked have become sick with lung cancer. A review of decades of research has recently shown that smoking marijuana may help cancer cells grow, but there is no direct link between the drug and lung cancer. High levels of air pollution, working with or near cancer-causing chemicals or materials (such as asbestos), and drinking water containing high levels of arsenic can increase your risk for lung cancer. Radiation therapy to the lungs can also increase the risk.”

NIH - Medical Encyclopedia Lung cancer - small cell “Small cell lung cancer (SCLC) is a fast-growing type of lung cancer. It tends to spread much more quickly than non-small cell lung cancer. There are three different types of small cell lung cancer: • Small cell carcinoma (oat cell cancer) • Mixed small cell/large cell carcinoma • Combined small cell carcinoma Most small cell lung cancers are the oat cell type. About 15% of all lung cancer cases are small cell lung cancer, according to the American Cancer Society. Small cell lung cancer is a bit more common in men than women. Causes - Smoking almost always causes small cell lung cancer. This type of lung cancer is rare in those who have never smoked. Small cell lung cancer usually starts in the air tubes (bronchi) in the center of the chest. Although the cancer cells are small, they grow quickly and create large masses (tumors) that can rapidly spread to other parts of the body, including the brain, liver, and bone.”

Mayo Clinic Lung Cancer "Lung cancer is the leading cause of cancer deaths in the United States, among both men and women. It claims more lives than colon, prostate, lymph and breast cancer combined. Yet most of these lung cancer deaths could have been prevented. That's because smoking accounts for nearly 90 percent of lung cancer cases. … Because lung cancer doesn't cause signs or symptoms in its earliest stages, it's often advanced by the time it's diagnosed. When symptoms do occur, the most common warning sign is a cough, which occurs when a tumor irritates the lining of the airways or blocks the passage of air. In addition to a new cough, be alert for: • "Smoker's cough" that worsens • Coughing up blood, even a small amount • Chest pain • Shortness of breath • New onset of wheezing • Repeated bouts of pneumonia or bronchitis • Hoarseness that lasts more than two weeks Lung cancer also may cause fatigue, loss of appetite and weight loss. If it has spread to other parts of your body (metastasized), you may have headaches or bone pain."

NHS - Lung cancer (Video) “Smoking is the most common cause of lung cancer. Around 90% of cases are due to smoking. Other causes include passive smoking and exposure to certain gases and chemicals. Primary and secondary lung cancer This article deals only with primary lung cancer. Primary lung cancer is cancer that originates in the lungs. Secondary lung cancer is cancer which starts in another part of the body and then spreads to the lungs. Types of primary lung cancer There are two main types of primary lung cancer - small cell lung cancer and non-small cell lung cancer. Around 80% of cases are non-small cell lung cancer. Non-small cell lung cancer includes three types: • squamous cell carcinoma, • adenocarcinoma, and • large cell carcinoma. Small cell and non-small cell lung cancers are treated in different ways. Therefore, it is very important that you have a number of tests, so that the exact type of cancer can be diagnosed. Around 10% of people with lung cancer will be cured (live for five years without the cancer returning). There are many treatments available which can reduce the effects of lung cancer, and slow down its progress, therefore improving your quality of life. “

Highlighted Articles

Non-small cell lung cancer: epidemiology, risk factors, treatment, and survivorship. (Mayo Clin Proc. 2008) “Non-small cell lung cancer accounts for 85% of all lung cancer cases in the United States. After the initial diagnosis, accurate staging of non-small cell lung cancer using computed tomography or positron emission tomography is crucial for determining appropriate therapy. When feasible, surgical resection remains the single most consistent and successful option for cure. However, close to 70% of patients with lung cancer present with locally advanced or metastatic disease at the time of diagnosis. Chemotherapy is beneficial for patients with metastatic disease, and the administration of concurrent chemotherapy and radiation is indicated for stage III lung cancer.”

Fruits, Vegetables And Teas May Protect Smokers From Lung Cancer, Researchers Report (2008) “UCLA researchers found that smokers who ingested high levels of natural chemicals called flavonoids in their diet had a lower risk of developing lung cancer, an important finding since more than 90 percent of lung cancers are caused by tobacco smoking.“

CancerHelp UK - Types of lung cancer "There are important differences between lung cancer that started in the lungs and lung cancer that has spread to the lung from another part of the body. … Primary lung cancer (cancer that has started in the lungs) "There are several different types of primary lung cancer. These are divided into two main types • Small cell lung cancer • Non-small cell lung cancer ... Secondary lung cancer (cancer that has spread to the lungs) Secondary cancer is cancer that has spread from somewhere else in the body. There are quite a few different cancers that can spread to the lungs, including breast cancer and bowel cancer"

Knee Pain May Signal Lung Cancer (2007)"Heavy smokers with knee arthritis may be experiencing an early sign of a difficult-to-treat lung cancer, research shows. … About 85 percent of all lung cancers are non-small cell lung cancer, according to the American Cancer Society. Unless it is caught early, non-small cell lung cancer is difficult to treat. It spreads to the bones in one in five cases and is well advanced by the time it is diagnosed in half of all cases."

[The epidemiology of lung cancer.] (Pneumonol Alergol Pol. 2007) "Worldwide, lung cancer is the most common cause of cancer mortality in males and females. In the Europe lung cancer accounts for 21% of all cancer cases in males and 29% of all cancer deaths."

Highlighted Internet Sites

NCI – Lung Cancer

NCI – What You Need To Know About Lung Cancer

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Notes

The 2007 Treatment Guidelines section will contain the 2007 published guidelines. To view Guidelines from previous years, view year 2006 Treatment Guidelines and 2005 InfoMedlinks (Articles section) or our Monthly Online Newsletter (under the Guidelines section).

Lung Cancer

Daily Treatment Report

Cognitive Therapy-CBT-Psychotherapy

Device Therapy

 

Drug Side-Effects and Interactions

Drugs

Exercise

General Information

Smoking Cessation: An Integral Part of Lung Cancer Treatment. (JJ.Oncology. 2010) “Lung cancer is the leading cause of cancer death in the US. About 50% of lung cancer patients are current smokers at the time of diagnosis and up to 83% continue to smoke after diagnosis. A recent study suggests that people who continue to smoke after a diagnosis of early-stage lung cancer almost double their risk of dying. Despite a growing body of evidence that continued smoking by patients after a lung cancer diagnosis is linked with less effective treatment and a poorer prognosis, the belief prevails that treating tobacco dependence is useless.”

Lung Cancer in Women: The Differences in Epidemiology, Biology and Treatment Outcomes (Expert Rev Resp Med. 2009)

Influence of smoking cessation after diagnosis of early stage lung cancer on prognosis: systematic review of observational studies with meta-analysis (BMJ 2010) “Conclusions This review provides preliminary evidence that smoking cessation after diagnosis of early stage lung cancer improves prognostic outcomes. From life table modelling, the estimated number of deaths prevented is larger than would be expected from reduction of cardiorespiratory deaths after smoking cessation, so most of the mortality gain is likely to be due to reduced cancer progression. These findings indicate that offering smoking cessation treatment to patients presenting with early stage lung cancer may be beneficial.”

Guidelines

NCCN Clinical Practice Guidelines in Oncology™ Non-Small Cell Lung Cancer (2010)

Immunotherapy

 

Internet Sites

Treatment Information

DrugBank (drug structure)

FDA - MedWatch (Drug Alerts)

National Comprehensive Cancer Network

NCI - Breast Cancer (PDQ®): Treatment

NCI - Dictionary of Cancer Terms

NCI - Drug Dictionary

NCI - Overview of Nutrition in Cancer Care

Drug-Food-Supplement Information

Drug Information Online

Drug Interaction Checker

DrugDigest (drug interactions)

FDA - Drug Interactions: What You Should Know

NIH - Botanical Dietary Supplements: Background Information

NIH - Drug, Supplements, and Herbal Information

NIH - Herbal Supplements: Consider Safety, Too

NIH - Medicines

NIH - Vitamin and Mineral Supplement Fact Sheets

Nutrition

Other

Radiation-Chemotherapy

Impact of Neoadjuvant Radiation on Survival in Stage III Non-Small-Cell Lung Cancer. (Int J Radiat Oncol Biol Phys. 2010)

Other Treatments

Experimental

WHITE TEA EXTRACT INDUCES APOPTOSIS IN NONSMALL CELL LUNG CANCER CELLS- THE ROLE OF PPAR-gamma AND 15-LIPOXYGENASE (Cancer Prev Res 2010)

Radiotherapy

Radiotherapy in small-cell lung cancer: Where should it go? (Lung Cancer. 2010)

Radiation May Help Those With Inoperable Lung Tumors “Almost 56 percent of patients who underwent the therapy, called stereotactic body radiation therapy (SBRT), were still alive three years after their treatment, according to preliminary findings from a study published in the March 17 issue of the Journal of the American Medical Association, a themed issue on cancer. By contrast, only about 25 percent to 30 percent of patients who receive conventional fractionated radiotherapy survive that long. "Stereotactic body radiation therapy controlled peripheral small tumors in a large majority of patients and had an impressive overall survival rate at three years," said study lead author Dr. Robert Timmerman, professor of radiation oncology at the University of Texas Southwestern Medical Center at Dallas, speaking at a Tuesday teleconference.”

Supplements-Vitamins-CAM

Study: Selenium not effective against lung cancer “Over the last 10 years, researchers followed more than 1,500 Stage I non-small cell lung cancer patients that had had their tumors surgically removed and were cancer free for at least 6 months. Patients got 200 micrograms of selenium a day or a placebo. The results were not encouraging. "This process is very insidious and takes years," said Dr. Daniel Karp, the study's principal investigator and professor in the Department of Thoracic/Head and Neck Medical Oncology at MD Anderson. "And unfortunately we were not able to show that selenium produced any clear benefit."”

Surgery

Transplantation

 

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