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Depression

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Depression

NIH - Medical Encyclopedia Depression

"Depression may be described as feeling sad, blue, unhappy, miserable, or down in the dumps. Most of us feel this way at one time or another for short periods. But true clinical depression is a mood disorder in which feelings of sadness, loss, anger, or frustration interfere with everyday life for an extended time. … The main types of depression include: Major depression -- five or more symptoms listed above must be present for at least 2 weeks, but major depression tends to continue for at least 6 months. (Depression is classified as minor depression if less than five depressive symptoms are present for at least 2 weeks.) and Dysthymia -- a chronic, generally milder form of depression but lasts longer -- usually as long as two years. Depression also includes atypical depression, postpartum depression, Premenstrual dysphoric disorder (PMDD), and Seasonal affective disorder (SAD). … If you are depressed for 2 weeks or longer, you should contact your doctor, who can offer treatment options. … Call 911, a suicide hotline, or get safely to a nearby emergency room if you have thoughts of suicide, a suicidal plan, or thoughts of harming yourself or others."

Highlighted Article

Regular exercise, anxiety, depression and personality: A population-based study. (Prev Med. 2006)

"This study corroborates and extends previous findings: regular exercise is cross-sectionally associated with lower neuroticism, anxiety and depression and higher extraversion and sensation seeking in the population."

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Notes

The 2007 Treatment Guidelines section will contain the 2007 published guidelines. To view Guidelines from previous years, view year 2006 Treatment Guidelines and 2005 InfoMedlinks (Articles section) or our Monthly Online Newsletter (under the Guidelines section).

Depression

Daily Treatment Report

Cognitive Therapy-CBT-Psychotherapy

Mindfulness CBT as Effective as Antidepressants in Preventing Depression Relapse

Brief Psychological Therapies for Depression, Anxiety, May Be Effective in Primary Care

Device Therapy

 

Drug Side-Effects and Interactions

Cataracts From Antidepressants?

Drugs

Exercise

Effect of Walking Distance on 8-Year Incident Depressive Symptoms in Elderly Men with and without Chronic Disease: The Honolulu-Asia Aging Study. (J Am Geriatr Soc. 2010) “CONCLUSION: Daily physical activity (>/=0.25 mile/day) is significantly associated with lower risk of 8-year incident depressive symptoms in elderly Japanese-American men without chronic disease at baseline.”

General Information

Broad Review of FDA Trials Suggests Antidepressants Only Marginally Better than Placebo “A new review of 4 meta-analyses of efficacy trials submitted to the US Food and Drug Administration (FDA) suggests that antidepressants are only "marginally efficacious" compared with placebo and "document profound publication bias that inflates their apparent efficacy." In addition, when the researchers also analyzed the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) trial, "the largest antidepressant effectiveness trial ever conducted," they found that "the effectiveness of antidepressant therapies was probably even lower than the modest one reported...with an apparent progressively increasing dropout rate across each study phase.”

Is unrecognized bipolar disorder a frequent contributor to apparent treatment resistant depression? (J Affect Disord. 2010)

Americans prefer drugs for depression: survey “Americans prefer drugs to talk therapy for depression, with nearly 80 percent taking a pill for the condition, Consumer Reports said on Tuesday. The most popular class of drugs remain the so-called SSRIs such as Prozac, the group found. People found newer, pricier antidepressants less desirable because of side-effects. Patients benefited just as much from therapy -- almost any kind of therapy, the consumer group found in its survey of 1,500 readers. Those surveyed said they improved just as much after seven or more sessions of talk therapy as if they took drugs and it did not matter if the therapist was a psychiatrist, psychologist or social worker. Nearly 80 percent of people who had been diagnosed with depression or anxiety were prescribed antidepressants.”

Guidelines

NGC - VA/DoD clinical practice guideline for management of major depressive disorder (MDD). (2009)

APA Releases Updated Treatment Guideline for Major Depression

Immunotherapy

 

Internet Sites

Treatment Information

DrugBank (drug structure)

FDA - Antidepressant Use in Children, Adolescents, and Adults

FDA - MedWatch (Drug Alerts)

Drug-Food-Supplement Information

Drug Information Online

Drug Interaction Checker

DrugDigest (drug interactions)

FDA - Drug Interactions: What You Should Know

NIH - Botanical Dietary Supplements: Background Information

NIH - Drug, Supplements, and Herbal Information

NIH - Herbal Supplements: Consider Safety, Too

NIH - Medicines

NIH - Vitamin and Mineral Supplement Fact Sheets

Nutrition

Other

Other Treatments

Radiotherapy

 

Supplements-Vitamins-CAM

Is Low Vitamin D Associated with Depression in Elders?

Longitudinal association of vitamin B-6, folate, and vitamin B-12 with depressive symptoms among older adults over time (American Journal of Clinical Nutrition 2010) “Our results support the hypotheses that high total intakes of vitamins B-6 and B-12 are protective of depressive symptoms over time in community-residing older adults.”

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