Cerebrospinal Fluid Shows Alzheimer's Disease Deterioration Much Earlier

CSF Mg and Ca as diagnostic markers for dementia with Lewy bodies (Neurobiology of Aging 2009)

Olfactory impairment is more marked in patients with mild dementia with Lewy bodies than those with mild Alzheimer disease. (J Neurol Neurosurg Psychiatry. 2009)

Practical suggestions on how to differentiate dementia with Lewy bodies from Alzheimer's disease with common cognitive tests (International Journal of Geriatric Psychiatry 2009)

SNM 2009: PET Can Be Used to Classify Dementia Subtype “Dr. Drzezga said it does occur in clinical practice that patients are prescribed inappropriate medications because of inappropriate disease classification. "It's good to have measures that give you an objective answer," said Dr. Drzezga. "The symptoms can be misleading, and imaging may give you a more definite proof of what patients are suffering from."“

Subcortical and deep cortical atrophy in Frontotemporal Lobar Degeneration. (Neurobiol Aging. 2009)

Alzheimer's and Even Mild Dementia Hasten Death “Those with Alzheimer's disease had a three-fold greater risk of dying compared to those not experiencing cognitive function problems. Those with mild cognitive impairment were 50 percent more likely to die. The risk of death increased as cognitive impairment became more severe.”

Chapter 11 lewy body dementia. (Int Rev Neurobiol. 2009)

Dietary fish and meat intake and dementia in Latin America, China, and India: a 10/66 Dementia Research Group population-based study. (Am J Clin Nutr. 2009) “CONCLUSIONS: Our results extend findings on the associations of fish and meat consumption with dementia risk to populations in low- and middle-income countries and are consistent with mechanistic data on the neuroprotective actions of omega-3 (n-3) long-chain polyunsaturated fatty acids commonly found in fish. The inverse association between fish and prevalent dementia is unlikely to result from poorer dietary habits among demented individuals (reverse causality) because meat consumption was higher in those with a diagnosis of dementia.”

Dietary intake of fish and omega-3 fatty acids in relation to long-term dementia risk. (Am J Clin Nutr. 2009) “CONCLUSION: In this Dutch cohort, who had a moderate consumption of fish and omega-3 PUFAs, these dietary factors do not appear to be associated with long-term dementia risk.”

Does Anxiety Affect Risk of Dementia? Findings From the Caerphilly Prospective Study. (Psychosom Med. 2009) “Conclusions: Anxiety is a risk factor for CIND and dementia. The extent to which the association is independent of depression and whether or not it is causal requires further study.”

Number of children is associated with neuropathology of Alzheimer's disease in women (Neurobiology of Aging 2009)

Prevalence and Causes of Early-Onset Dementia in Japan. A Population-Based Study (Stroke 2009) “Results—We identified 617 subjects with EOD. The estimated prevalence of EOD in the target population was 42.3 per 100 000 (95% CI, 39.4 to 45.4). Of the illnesses that cause EOD, vascular dementia was the most frequent (42.5%) followed by Alzheimer disease (25.6%), head trauma (7.1%), dementia with Lewy bodies/Parkinson disease with dementia (6.2%), frontotemporal lobar degeneration (2.6%), and other causes (16.0%). Conclusions—The prevalence of EOD in Japan appeared to be similar to that in Western countries with the notable exception that vascular dementia was the most frequent cause of EOD in Japan.”

Bone lead levels are associated with measures of memory impairment in older adults. (Neurotoxicology. 2009)

Overweight in midlife and risk of dementia: a 40-year follow-up study (International Journal of Obesity 2009) “Conclusions: This study gives further support to the notion that overweight in midlife increases later risk of dementia. The risk is increased for both Alzheimer's disease and vascular dementia, and follows the same pattern for men and women.”

Dietary fish and meat intake and dementia in Latin America, China, and India: a 10/66 Dementia Research Group population-based study (Am J Clin Nutr 2009) “Results: Dietary intakes and the prevalence of dementia varied between sites. We combined site-specific Poisson regression prevalence ratios (PRs) for the association between fish and meat consumption and dementia in 2 fixed-effect model meta-analyses adjusted for sociodemographic and health characteristics and fish and meat consumption as appropriate. We found a dose-dependent inverse association between fish consumption and dementia (PR: 0.81; 95% CI: 0.72, 0.91) that was consistent across all sites except India and a less-consistent, dose-dependent, direct association between meat consumption and prevalence of dementia (PR: 1.19; 95% CI: 1.07, 1.31). Conclusions: Our results extend findings on the associations of fish and meat consumption with dementia risk to populations in low- and middle-income countries and are consistent with mechanistic data on the neuroprotective actions of omega-3 (n–3) long-chain polyunsaturated fatty acids commonly found in fish. The inverse association between fish and prevalent dementia is unlikely to result from poorer dietary habits among demented individuals (reverse causality) because meat consumption was higher in those with a diagnosis of dementia.”

Eating Curry Every Week 'could Prevent Dementia' “…curcumin prevented the spread of amyloid plaques, found outside brain cells. … Studies looking at populations show that people who eat a curry meal two or three times a week seem to have a lower risk for dementia, he told the Annual Meeting. "Those studies seem to show that you need only consume what is part of the normal diet - but the research studies are testing higher doses to see if they can maximise the effect. It would be equivalent of going on a curry spree for a week." However, curry may be just one of the ingredients that prevent degeneration of the brain. "If you are eating fatty burgers and smoking then don't expect an occasional curry to counterbalance a poor lifestyle. However, if you have a good diet and take plenty of exercise, eating curry regularly could help prevent dementia," he said. Turmeric is also found in mustard and Professor Doraiswamy predicted a day when - for those unable, or unwilling, to consume curries regularly - the public might be advised to take a 'curry' pill every day if the findings are confirmed in human studies.”

Omega-3 fatty acids and dementia. (Prostaglandins Leukot Essent Fatty Acids. 2009)