:: June 2009

Welcome to our Monthly Online Newsletter!

View all Treatment articles in our Treatment Report . The most recent articles are listed on top (not in alphabetical order). Click on the Topic on our home page and then the subtopic - Treatment Report. Stay updated on drugs and their side effects, and various other treatments, including exercise, nutrition, and supplements.

Highlighted Article

Researcher claims disease overtreated “It did not make sense to do something which would increase peoples risk "if you are offering something which has a considerable hazard, you have really added to their problems". The difficulty was that the commonly used prostate specific antigen test (PSA) led to over-diagnosis of cancers and over treatment. About 30% of men over 50 had a small tumour on their prostate which, when studied under a microscope was indistinguishable from cancer. A vast majority of these tumours did not appear to become a clinical disease or even cause symptoms. Research into randomised trials using PSA for screening showed that the over-diagnosis of cancers could be as high as 50%. Men were undergoing radical prostatectomy or radiotherapy which could result in chronic incontinence (urinary or faecal), impotence, or in some instances, death, he said. Dr Cox estimates that about 2000 cases of prostate cancer are detected by PSA testing a year in New Zealand and about half of them would never become clinically relevant. “

Clinical Guidelines

ESMO Minimum Clinical Recommendations for diagnosis, treatment and follow-up of prostate cancer (2005)

NCCN Clinical Practice Guidelines in Oncology: Prostate Cancer Early Detection (2007)

NCCN - Prostate Cancer Treatment Guidelines for Patients ø Version V, September 2005

New Guidelines Recommend 5-Alpha Reductase Inhibitors for Preventing Prostate Cancer

NGC - ACR Appropriateness Criteria for pretreatment staging of clinically localized prostate cancer.

NGC - American Society of Clinical Oncology recommendations for the initial hormonal management of androgen-sensitive metastatic, recurrent, or progressive prostate cancer. (2004)

NGC - GUIDELINE SYNTHESIS SCREENING FOR PROSTATE CANCER

NGC - Locally advanced (high-risk) prostate cancer. (2006)

NGC - Maximal androgen blockade for the treatment of metastatic prostate (2003)

NGC - NATIONAL GUIDELINE CLEARINGHOUSE™ (NGC) GUIDELINE SYNTHESIS: SCREENING FOR PROSTATE CANCER (2007 )

NGC - Node-positive prostate cancer. (2006)

NGC - Obstructive voiding symptoms secondary to prostate disease. (2005)

NGC - Post-treatment follow-up of prostate cancer. (2005)

NGC - Pretreatment staging prostate cancer. (2005)

NGC - Prostate cancer. (2005)

NGC - Screening for prostate cancer in U.S. men: ACPM position statement on preventive practice. (2008)

NGC - Screening for prostate cancer: U.S. Preventive Services Task Force recommendation statement. (2008)

NGC - The use of bisphosphonates in men with hormone-refractory prostate cancer. (2005)

Internet Sites

Featured site

NCI - Prostate Cancer

Detection Methods (PSA)

NCI - Background on Prostate Cancer

NCI - Early Prostate Cancer: Questions and Answers

NCI - General Information About Prostate Cancer

NCI - Genetics of Prostate Cancer

NCI - Know Your Options: Understanding Treatment Choices for Prostate Cancer

NCI - Prostate Cancer (PDQ¬): Prevention

NCI - Prostate Cancer (PDQ®): Screening (professional version)

NCI - Prostate Cancer (PDQ®): Screening (patient version)

NCI - Prostate Cancer (PDQ¬): Treatment

NCI - Understanding Prostate Changes: A Health Guide for Men

NIH - Medical Encyclopedia Prostate cancer

NIH - Prostate Cancer

Prostate Cancer

Related Topics - Highlighted Articles

Prostatitis

Sexually transmitted diseases and other urogenital conditions as risk factors for prostate cancer: a case-control study in Wayne County, Michigan. (Cancer Causes Control. 2005) "Conclusions: Among all subjects, prostate cancer was associated with prostatitis and BPH history, but not with STD or vasectomy history."

Benign Prostatic Hyperplasia

Family history of cancer and the risk of prostate cancer and benign prostatic hyperplasia. (Int J Cancer. 2005) "Our study adds further information on the association of family history of cancer and risk of PC and is, to our knowledge, the first comprehensive epidemiologic information on family history of cancer and risk of BPH."

In this newsletter:

Diagnosis, Imaging, and Screening
General Information
Risk Factors
Risk Reduction

	Diagnosis, Imaging, and Screening

	General Information
Group Takes Aim at Prostate Cancer Claims “Early studies suggested selenium, an antioxidant, could have some protective effect against cancer. But a major government-sponsored trial published in January, called SELECT (The Selenium and Vitamin E Cancer Prevention Trial), concluded that selenium "did not prevent prostate cancer" in a population of healthy men. But the group complained that Bayer Healthcare LLC, which makes both products, continues to claim on packaging and in ads that they help reduce the risk of prostate cancer.”

	Risk Factors

	Risk Reduction
ACSM 2009: Exercise May Lower Prostate Cancer Risk in Black Men Diet May Reduce Risk Of Prostate Cancer “The researchers found that a diet low in fat, high in vegetables and fruit, and avoiding high energy intake, excessive meat, and excessive dairy products and calcium intake may be helpful in preventing prostate cancer, and for patients diagnosed with prostate cancer. Specifically, consumption of tomatoes, cauliflower, broccoli, green tea, and vitamins including Vitamin E and selenium seemed to propose a decreased risk of prostate cancer. Consumption of highly processed or charcoaled meats, dairy products, and fats seemed to be correlated with prostate cancer.” Green tea could delay prostate cancer: U.S. study “Active compounds in green tea may slow down the progression of prostate cancer, researchers reported on Friday. Capsules made using green tea extracts called polyphenols lowered levels of proteins that tumors use to grow, the researchers found.” Strategies for prostate cancer prevention: Review of the literature (Indian J Urol. 2008)