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Supplements and Nutrition

:: June 2009


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Cardiovascular: General

The role of omega-3 fatty acids in cardiac protection: an overview. ( Front Biosci. 2005) "Fish oil has historically been thought to be good for cardiovascular health; however, data have revealed a stronger cardioprotective role of fish oil in recent years. Fish oil and specifically omega-3 fatty acids exhibit cardioprotective effects by mainly improving mortality in coronary artery disease patients. This is achieved through multiple mechanisms with the antiarrhythmic mechanism being the most prominent one. Effects on sodium and calcium channels and heart rate variability are well-accepted mechanisms of how omega-3 fatty acids exercise antiarrhythmic effects."


Cancer: Prostate

Chemoprevention of prostate cancer. (Crit Rev Oncol Hematol. 2005) "A major advance in prevention of prostate cancer came in 2003 with the publication of the Prostate Cancer Prevention Trial (PCPT). This overview summarizes the results of that trial, the design of other large-scale trials, and advances in understanding of the molecular mechanisms underlying the effect of other promising agents, including dutasteride, selenium, Vitamin E, Vitamin D, COX-2 inhibitors, lycopene, and green tea."

Selenium/cadmium ratios in human prostates: indicators of prostate cancer risk of smokers and nonsmokers, and relevance to the cancer protective effects of selenium. (Biol Trace Elem Res. 2005) "Selenium (Se) in a large-scale human supplementation trial has been shown to significantly reduce the incidence of prostate cancer in elderly men. Because Se is known to interact with cadmium (Cd), it has been suggested that its cancer protective action could be attributable in part to its interaction with Cd, a toxic and suspected carcinogenic element, which is found in many foods, in drinking water, and in the environment. ? "

 

In this newsletter:
General Information

Anticancer effects of phytosterols. (Eur J Clin Nutr. 2009)

Carnitine status of pregnant women: effect of carnitine supplementation and correlation between iron status and plasma carnitine concentration. (Eur J Clin Nutr. 2009)

COENZYME Q10 AND MALE INFERTILITY. “In conclusion, the exogenous administration of CoQ10 increases both ubiquinone and ubiquinol levels in semen and can be effective in improving sperm kinetic features in patients affected by idiopathic asthenozoospermia.”

Curcumin reverses impaired cognition and neuronal plasticity induced by chronic stress. (Neuropharmacology. 2009) “Thus, curcumin may be an effective therapeutic for learning and memory disturbances as was seen within these stress models, and its neuroprotective effect was mediated in part by normalizing the corticosterone response, resulting in down-regulating of the pCaMKII and glutamate receptor levels.”

Eating Curry Every Week 'could Prevent Dementia' “…curcumin prevented the spread of amyloid plaques, found outside brain cells. … Studies looking at populations show that people who eat a curry meal two or three times a week seem to have a lower risk for dementia, he told the Annual Meeting. "Those studies seem to show that you need only consume what is part of the normal diet - but the research studies are testing higher doses to see if they can maximise the effect. It would be equivalent of going on a curry spree for a week." However, curry may be just one of the ingredients that prevent degeneration of the brain. "If you are eating fatty burgers and smoking then don't expect an occasional curry to counterbalance a poor lifestyle. However, if you have a good diet and take plenty of exercise, eating curry regularly could help prevent dementia," he said. Turmeric is also found in mustard and Professor Doraiswamy predicted a day when - for those unable, or unwilling, to consume curries regularly - the public might be advised to take a 'curry' pill every day if the findings are confirmed in human studies.”

Effect of glucosamine or chondroitin sulfate on the osteoarthritis progression: a meta-analysis. (Rheumatol Int. 2009)

Effects of curcuminoid supplement on cardiac autonomic status in high-fat–induced obese rats (Nutrition 2009)

Fish-oil supplementation induces antiinflammatory gene expression profiles in human blood mononuclear cells. (Am J Clin Nutr. 2009)

Group Takes Aim at Prostate Cancer Claims “Early studies suggested selenium, an antioxidant, could have some protective effect against cancer. But a major government-sponsored trial published in January, called SELECT (The Selenium and Vitamin E Cancer Prevention Trial), concluded that selenium "did not prevent prostate cancer" in a population of healthy men. But the group complained that Bayer Healthcare LLC, which makes both products, continues to claim on packaging and in ads that they help reduce the risk of prostate cancer.”

Iron and menopause: Does increased iron affect the health of postmenopausal women? (Antioxid Redox Signal. 2009)

magnesium citrate

Omega-3 fatty acids and dementia. (Prostaglandins Leukot Essent Fatty Acids. 2009)

Randomized, double-blind, placebo-controlled trial of iron supplementation in female soldiers during military training: effects on iron status, physical performance, and mood (American Journal of Clinical Nutrition 2009) “Conclusions: Iron status is affected by BCT, and iron supplementation attenuates the decrement in indicators of iron status in female soldiers. Furthermore, iron supplementation may prove to be beneficial for mood and physical performance during the training period. Future efforts should identify and treat female soldiers or athletes who begin training regimens with iron deficiency or iron deficiency anemia.”

Selenium and selenium-antagonistic elements in nutritional cancer prevention. (Crit Rev Biotechnol. 2009) “Selenium is an essential trace element with antioxidative, antimutagenic, antiviral and anticarcinogenic properties. There is increasing evidence that the dietary selenium intakes are sub-optimal in the populations of many countries and that human cancer mortalities would significantly decline if additional selenium was made available either through supplementation or the fortification of certain foods. … Cadmium, for example, is a key risk-increasing element for prostate cancer; for breast cancer, Cd, Cr, Zn are mainly contributing; for bronchial cancer (in smelter workers), Cd, As, Cr, Sb, Co, La, all these elements are in a reciprocal relationship with Se. While selenium remains the key cancer-protective trace element, the interpretation of its mode of action necessitates consideration of the effects of selenium antagonistic elements.”

Soy proteins and isoflavones affect bone mineral density in older women: a randomized controlled trial (American Journal of Clinical Nutrition 2009) “Conclusions: Because soy protein and isoflavones (either alone or together) did not affect BMD, they should not be considered as effective interventions for preserving skeletal health in older women. The negative correlation between dietary protein and bone turnover suggests that increasing protein intakes may suppress skeletal turnover.”

Soya isoflavone supplementation enhances spatial working memory in men. (Br J Nutr. 2009)

 

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