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Cognitive Decline - Dementia

:: November 2009


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View all Treatment articles in our Treatment Report . The most recent articles are listed on top (not in alphabetical order). Click on the Topic on our home page and then the subtopic - Alzheimer's Daily Treatment Report, FTD Daily Report, Lewy Body Daily Report, or the Vascular Dementia Daily Report. Stay updated on drugs and their side effects, and various other treatments, including exercise, nutrition, and supplements.

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Related InfoMedSearch Topics (3 selected)

Related Topics - Highlighted Articles

Cardivascular: General

C-Reactive Protein and Cerebral Small-Vessel Disease. The Rotterdam Scan Study (Circulation 2005) "Background--Inflammatory processes are involved in the development and consequences of atherosclerosis. Whether these processes are also involved in cerebral small-vessel disease is unknown. Cerebral white matter lesions and lacunar brain infarcts are caused by small-vessel disease and are commonly observed on MRI scans in elderly people. These lesions are associated with an increased risk of stroke and dementia. Ä Conclusions--Inflammatory processes may be involved in the pathogenesis of cerebral small-vessel disease, in particular, the development of white matter lesions."


Neural Injury: Neurodegeneration

Oxidative DNA damage in peripheral leukocytes of mild cognitive impairment and AD patients. (Neurobiol Aging. 2005) "It is well established that oxidative stress plays a key role in the degenerative neuronal death and progression of Alzheimer's disease (AD), although it is not clear if it is the primary triggering event in the pathogenesis of this disorder. Mild cognitive impairment (MCI) is a clinical condition between normal aging and AD, characterized by a memory deficit without loss of general cognitive and functional abilities. Ä Our results give a further indication that oxidative stress, at least at the DNA level, is an earlier event in the pathogenesis of AD."

 

Diagnosis, Imaging, and Screening
General Information
Risk Factors

Dementia: Rare Brain Disorder Is Highly Hereditary “The brain disorder, called frontotemporal dementia, is formerly known as Pick's disease and destroys parts of the brain, leading to dementia, including problems with language or changes in behavior and personality. The disease often affects people under the age of 65.”

Frontotemporal Lobar Degeneration Highly Heritable “FTLD is a genetically and pathologically heterogenous degenerative disorder, the authors write, with a number of different syndromes falling into the FTLD spectrum. The most common syndrome is behavioral variant frontotemporal dementia, which causes patients to present with behavioral or personality changes. Less commonly, FTLD can present as 1 of 3 different language impairments that fall under the umbrella of primary progressive aphasia, including semantic dementia, progressive nonfluent aphasia, and the logopenic/phonologic variant of primary progressive aphasia, they write. FTLD also overlaps with motor disorders, including the parkinsonian disorders corticobasal syndrome and progressive supranuclear palsy and frontotemporal dementia–motor neuron disease.”

High Waist-To-Hip Ratio in Midlife Linked to Later Dementia “"These data emphasize the importance of maintaining a healthy body weight throughout life, and that the prevention of Alzheimer's disease is a life-long process," lead author Dr. Deborah R. Gustafson, of the University of Gothenburg, Sweden, told Reuters Health.”

The APOE epsilon–4 Allele Is Associated with Incident Mild Cognitive Impairment among Community–Dwelling Older Persons (Neuroepidemiology 2009)

 

Risk Reduction
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