:: January 2012

Welcome to our Monthly Online Newsletter!

View all Treatment articles in our Treatment Report . The most recent articles are listed on top (not in alphabetical order). Click on the Topic on our home page and then the subtopic - Alzheimer's Daily Treatment Report, FTD Daily Report, Lewy Body Daily Report, or the Vascular Dementia Daily Report. Stay updated on drugs and their side effects, and various other treatments, including exercise, nutrition, and supplements.

Highlighted Articles

Our Highlighted Articles are now being included in our Weekly Featured Articles site. If you have not already signed up for our Alerts newsletter which links to this site, please do so at our sign up page. Stay current and save time. Free access to our Weekly Featured Articles and Weekly Featured Brain Articles.

Clinical Guidelines

AHRQ - Pharmacological Treatment of Dementia: Summary (2004)

MOH (Singapore) - Dementia (2007)

New Guidelines Address Care of Patients With Alzheimer's Dementia

NGC - Dementia. (2007)

NGC - GUIDELINE SYNTHESIS - ALZHEIMER'S DISEASE AND RELATED DEMENTIAS. PART II. ASSESSMENT AND DIAGNOSIS (2006)

NGC - Guidelines for Alzheimer's disease management. (2002)

NGC - Non-pharmacologic management of agitated behaviors in persons with Alzheimer disease and other chronic dementing illnesses. (2004)

NGC - Practice parameter: early detection of dementia: mild cognitive impairment (an evidence-based review). Report of the Quality Standards Subcommittee of the American Academy of Neurology. (2001)

NGC - Screening for dementia: recommendations and rationale. (2003)

Internet Sites

Featured sites

NIH - Dementia

NIH - Dementia Information Page

Alzheimer's Disease

NIH - Alzheimer's Disease

NIH - Alzheimer's Disease Resources

NIH - Caring for Someone with Alzheimer's

NIH - Dementia

NIH - Medical Encyclopedia Alzheimer's Disease

NIH - National Institute on Aging

NIH - NIA ADEAR

NIH - NINDS Alzheimer's Disease Information Page

What is Alzheimer Disease?

FTD

NIH - Medical Encyclopedia Pick’s disease

NIH - NINDS Pick's Disease Information Page

Pick's Disease

Pick's Information Page

Lewy Body Dementia

Lewy Body Dementia Organization

NIH - ADEAR Dementia with Lewy Bodies: Not Exactly Alzheimerês or Parkinsonês Disease

NIH - NINDS Dementia With Lewy Bodies Information Page

Vascular Dementia

Binswanger's Disease

NIH - ADEAR Multi-Infarct Dementia

NIH - Medical Encyclopedia Multi-infarct dementia

NIH - NINDS Binswanger's Disease Information Page

NIH - NINDS Multi-Infarct Dementia Information Page

Related Topics - Highlighted Articles

Cardivascular: General

C-Reactive Protein and Cerebral Small-Vessel Disease. The Rotterdam Scan Study (Circulation 2005) "Background--Inflammatory processes are involved in the development and consequences of atherosclerosis. Whether these processes are also involved in cerebral small-vessel disease is unknown. Cerebral white matter lesions and lacunar brain infarcts are caused by small-vessel disease and are commonly observed on MRI scans in elderly people. These lesions are associated with an increased risk of stroke and dementia. Ä Conclusions--Inflammatory processes may be involved in the pathogenesis of cerebral small-vessel disease, in particular, the development of white matter lesions."

Neural Injury: Neurodegeneration

Oxidative DNA damage in peripheral leukocytes of mild cognitive impairment and AD patients. (Neurobiol Aging. 2005) "It is well established that oxidative stress plays a key role in the degenerative neuronal death and progression of Alzheimer's disease (AD), although it is not clear if it is the primary triggering event in the pathogenesis of this disorder. Mild cognitive impairment (MCI) is a clinical condition between normal aging and AD, characterized by a memory deficit without loss of general cognitive and functional abilities. Ä Our results give a further indication that oxidative stress, at least at the DNA level, is an earlier event in the pathogenesis of AD."

In this newsletter:

Diagnosis, Imaging, and Screening
General Information
Risk Factors
Risk Reduction

	Diagnosis, Imaging, and Screening
PET Effectively Detects Dementia Following A Decade Of Research

	General Information
Alzheimer's Damage Occurs Early Brain microbleeds and Alzheimer’s disease: innocent observation or key player? (Brain 2011) Cholesterol and Late-Life Cognitive Decline. (J Alzheimers Dis. 2012) Dementia May Lead to Avoidable Hospitalizations Mental Decline Can Start at 45, Study Finds Severe, rapid memory loss linked to future, fatal strokes Vitamin A and Alzheimer's disease. (Geriatr Gerontol Int. 2011) Why Older People Lose Their Memory

	Risk Factors
Insulin-Linked Hormone May Also Raise Alzheimer's Risk Kidney Dysfunction and Cognitive Decline in Women. (Clin J Am Soc Nephrol. 2012)

	Risk Reduction
Exercise May Help Those at Higher Risk for Alzheimer's: Study “A new study finds that an active lifestyle may help protect against Alzheimer's-related brain changes in people who have a well-known genetic risk factor. This factor is the e4 allele (version) of the apolipoprotein E (APOE) gene. "The presence of an APOE e4 allele is the most established genetic risk factor for Alzheimer disease, with a higher percentage of individuals with Alzheimer's disease having an e4 allele in comparison with the general population," the authors write in the article published online Jan. 9 in the journal Archives of Neurology.” Lifestyle and the Risk of Dementia in Japanese-American Men. (J Am Geriatr Soc. 2011) Steady Diet of Mental Stimulation Might Reduce Alzheimer's Risk “People who engage in activities such as reading and playing games throughout their lives may be lowering levels of a protein in their brains that is linked to Alzheimer's disease, a new study suggests. Although whether the buildup of the protein, beta amyloid, causes Alzheimer's disease is debatable, it is a hallmark of the condition, the researchers noted. "Staying cognitively active over the lifetime may reduce the risk of Alzheimer's by preventing the accumulation of Alzheimer's-related pathology," said study author Susan Landau, a research scientist at the Helen Wills Neuroscience Institute at the University of California, Berkeley.”